A5102943539- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Electrolyte and hormonal disorders
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Hepatitis Viruses Studies and Epidemiology
- Heart Rate Variability and Autonomic Control
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Kidney Stones and Urolithiasis Treatments
- Magnesium in Health and Disease
- Bladder and Urothelial Cancer Treatments
- Peripheral Artery Disease Management
- Helicobacter pylori-related gastroenterology studies
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Vitamin D Research Studies
- Renal and related cancers
- Liver Diseases and Immunity
- Birth, Development, and Health
- Nutrition and Health in Aging
Semmelweis University
2013-2023
Heidelberg University
2007-2022
Hungarian Academy of Sciences
2001-2013
Background and objectives Steroid-resistant nephrotic syndrome is a rare kidney disease involving either immune-mediated or genetic alterations of podocyte structure function. The nature, heterogeneity, slow evolution the disorder are major obstacles to systematic genotype-phenotype, intervention, outcome studies, hampering development evidence-based diagnostic therapeutic concepts. To overcome these limitations, PodoNet Consortium has created an international registry for congenital...
Abstract The peritoneum plays an essential role in preventing abdominal frictions and adhesions can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal 69 omental specimens were obtained from 107 patients (0.1–60 years) undergoing surgery for disease affecting the automated quantitative histomorphometry immunohistochemistry. mesothelial cell layer morphology protein expression pattern is similar...
Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and D-fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether levels influence proteinuria progression in children, we performed a post hoc analysis of the Effect Strict Blood Pressure Control ACE Inhibition on...
The impact of peritoneal dialysis (PD) associated peritonitis on membrane integrity is incompletely understood. Children are particularly suited to address this question, since they largely devoid preexisting tissue damage and life-style related alterations. Within the International Peritoneal Biobank, 85 standardized parietal samples were obtained from 82 children neutral pH PD fluids with low glucose degradation product (GDP) content. 37 patients had a history 16 two or more episodes. Time...
24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily of healthy schoolchildren and patients with hypertension. The subjects studied were 123 a mean (SD) age 12.5 (1.6) years (range 9.5-14.5 years), children borderline or mild hypertension, 17 renal hypertension function, 10 chronic failure, six allograft. In eight definite disease second measurement after treatment modification. monitor used for ABPM validated mercury column manometer. signed...
Abstract: PTDM plays a role in chronic allograft nephropathy and decreases graft patient survival. Considering the serious outcome of hyperglycemia, importance early recognition few data children, this retrospective analysis we studied characteristics risk factors 45 pediatric renal transplant recipients receiving Tac or CyA‐based immunosuppression. Fasting blood sampling OGTT were performed. has been developed six patients (13%), while seven children (16%) had IGT, with overall incidence...
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The severity and dynamics of renal tissue damage in chronic kidney disease (CKD) may be reflected by the urinary excretion vasoactive growth factors released damaged kidney. Urinary ET-1, TGF-β1 VEGF 165 was evaluated 303 children with CKD stage II–IV (GFR 48 ± 22 ml/min/1.73 m 2 ) 81 age-matched healthy controls. Major groups were hypo-/dysplastic ( N = 183), obstructive uropathies 47), glomerulopathies 34), nephronophthisis 19) polycystic 20).
Schaefer B, Rusai K, Toth A, Pasti Ujszaszi Kreko M, Horvath E, Sallay P, Reusz GS, Merkely Tulassay T, Szabo AJ. Cardiac magnetic resonance imaging in children with chronic kidney disease and renal transplantation. Abstract: CV is the major cause of death patients CKD. Recently, CMR emerges as a complementary method providing advantages cardiac assessment; however, data on pediatric CKD are scarce. We performed 15 children: two CKD, six peritoneal dialysis, seven hemodialysis, 18 5.1...
Endothelial dysfunction is an early manifestation of cardiovascular disease (CVD) and consistently observed in patients with chronic kidney (CKD). We hypothesized that CKD associated systemic damage to the microcirculation, preceding macrovascular pathology. To assess degree "uremic microangiopathy", we have measured microvascular density biopsies omentum children CKD.Omental tissue was collected from 32 healthy (0-18 years) undergoing elective abdominal surgery 23 age-matched cases stage 5...
Abstract Given the increase in CV morbidity after RTx and scarcity of events pediatrics, surrogate markers should be assessed to characterize damage this population. AASI is a marker arterial stiffness adults, predicting cardio‐ cerebrovascular morbidity. Our aim was assess determinants children (n = 54, 15.5 ± 3.5 yr) examine its relationship central PWV . calculated from 24 h ABPM determined by applanation tonometry, body composition multifrequency bioimpedance measurement. The dipping...
Low heart rate variability (HRV) is an independent risk factor of cardiac mortality in patients with end-stage renal disease (ESRD). It has been explained by uremic parasympathetic neuropathy. Sympathetic overactivity can also reduce HRV. Our aim was to determine whether there vagal activity ESRD that masked sympathetic activity.The effect propranolol on HRV examined 13 ESRD, aged 20.1 +/- 7.6 years without diabetes. All were given intravenous (0.05 mg/kg) once and placebo a randomized,...
Abstract NODAT and IGT are well‐known complications of immunosuppressive therapy after transplantation being a risk factor for cardiovascular disease affecting patient graft survival. Therefore, early identification treatment high importance. In this study, we examined the glycemic homeostasis 20 renal‐transplanted children using routine laboratory tests continuous glucose monitoring system ( CGMS ). Six patients (30%) had , one (5%). The HOMA index was in an abnormal range 35% all 67%...
The Na + ‐K ATPase enzyme plays an essential role in the regulation of cell composition and volume. Enzyme activity itself is regulated by substrate availability several hormones. In adult uraemic patients red blood decreased. However, it unknown if children with uraemia exhibit same phenomenon. Therefore, present study we examined whether endogenous digoxin‐like factors (EDLF) physicochemical membrane properties play a erythrocyte adolescents. Healthy age‐matched were used as controls. was...