A5000869820- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Reproductive Health and Technologies
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
- Childhood Cancer Survivors' Quality of Life
- Organ Transplantation Techniques and Outcomes
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Acute Kidney Injury Research
- Hormonal and reproductive studies
- Abdominal Trauma and Injuries
- Sexual Differentiation and Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Mesenchymal stem cell research
- Testicular diseases and treatments
- Telomeres, Telomerase, and Senescence
- Full-Duplex Wireless Communications
- Sepsis Diagnosis and Treatment
- Celiac Disease Research and Management
- Erythropoietin and Anemia Treatment
University of Helsinki
2016-2025
Helsinki University Hospital
2015-2025
Weatherford College
2024
Helsinki Art Museum
2024
Helsinki Children's Hospital
2017-2019
Turku University Hospital
2017
ABSTRACT Background Physical performance capacity (PPC) of pediatric heart transplant (HT) recipients is reportedly low to normal, and longitudinal follow‐up these patients recommended. However, no recommendation for a method available. In this study, the correlation between 6‐min walk test (6MWT), various clinical parameters, physical set was evaluated develop simple tool PPC. Methods Fifteen HT 392 historical controls were tested at median age 15.4 years. PPC with 6MWT consisting six...
This study was conducted to evaluate the pubertal development in adolescents after renal transplantation (RTx) childhood.We performed a retrospective review of medical records 109 RTx recipients (72 males) transplanted at median age 4.5 years (range: 0.9-15.8 years). Data on clinical signs puberty, growth, bone age, medication, and graft function 98 patients were analyzed. Furthermore, serum levels reproductive hormones 87 assessed progression outcome development.The onset puberty averaged...
Arterial hypertension is a major risk factor for cardiovascular disease after solid organ transplantation, emphasizing the need blood pressure ( BP ) monitoring. The authors studied 24‐hour ambulatory monitoring ABPM parameters (index, load, dipping) and their predictive value with regard to as well correlations graft function metabolic such obesity dyslipidemias. profiles of 111 renal, 29 heart, 13 liver transplant recipients were retrospectively analyzed 5 10 years (median 5.1 years)....
Data on comorbidities in children kidney replacement therapy (KRT) are scarce. Considering their high relevance for prognosis and treatment, this study aims to analyse the prevalence implications of European KRT.We included data from patients <20 years age when commencing KRT 2007 2017 22 countries within Society Paediatric Nephrology/European Renal Association Registry. Differences between with without access transplantation (KT) patient graft survival were estimated using Cox...
Background This study was conducted to assess reproductive endocrine function, testicular volume, semen quality, and fertility in adult male patients after renal transplantation (RTx) during childhood or adolescence. Methods Twenty-four RTx recipients (median age: 28.1 years) were examined at a median of 18.6 years RTx. Reproductive hormone levels samples studied compared those 56 age-matched controls 30.2 years). Eight men (33%) had been treated with cyclophosphamide. Medical records...
Abstract Aim Bilateral nephrectomy is commonly performed in patients with congenital nephrotic syndrome of the Finnish type. The optimal timing unclear. Methods Growth, thromboembolic events, infections, transplant‐related complications and ability to eat were compared between infants early (Group 1, n = 13) late 2, 10) nephrectomy. ‘Early’ was defined as at 7‐kg body weight followed by peritoneal dialysis ‘late’ ≥10 kg 3–4 weeks haemodialysis kidney transplantation. Patients until end first...
The NPRTSG has collected data on pediatric KTx since 1994. registry archives information from all centers that perform in Denmark, Finland, Norway, and Sweden 100% coverage. first report was published 1998 based the 1982─1996 period. present provides 602 Nordic countries 1997 to 2012. Comparison of patient demographics one- three-yr graft survivals between two time cohorts revealed no significant change recipient donor demographics. number transplantations increased by approximately 30%,...
Background Heart surgery requiring cardiopulmonary bypass (CPB) causes an inflammatory response which may further induce acute kidney injury (AKI). In the present randomized controlled study we evaluated whether corticosteroids can prevent CPB related AKI in neonates undergoing heart surgery. Methods Forty were to receive 2 mg/kg methylprednisolone followed by hydrocortisone infusion 0.2 mg/kg/h perioperatively with tapering doses for 5 days, or placebo administered a similar fashion. The...
Abstract Background History of chronic kidney disease and transplantation is known to influence physical performance capacity. The aim this study was compare the pediatric transplant recipients healthy controls find possible correlations between clinical parameters Methods Twenty-four (62.5% boys) were tested at a median age 10.8 years. Physical capacity with test set including six different components assessing muscle endurance, strength, speed, flexibility. control group consisted 273...
Abstract Background The prevalence of malignancies after pediatric solid organ transplantation was evaluated in a nationwide study. Methods All patients who had undergone kidney, liver, or heart during childhood between the years 1982 and 2015 Finland were identified. inclusion criteria age under 16 at over 18 last follow-up day. A total 233 (137 53 43 heart) transplant recipients enrolled. Controls ( n = 1157) matched by year birth, gender, hometown identified using Population Register...
Abstract Background Only a few studies reporting the long-term outcome of children with idiopathic tubulointerstitial nephritis (TIN) and uveitis syndrome (TINU) are available. We studied kidney ocular in nationwide cohort TIN or TINU. Methods All patients followed up for minimum 1 year by paediatrician an ophthalmologist were enrolled. The data on plasma creatinine (P-Cr), estimated glomerular filtration rate (eGFR), proteinuria, hypertension collected retrospectively. Results Fifty-two...
Abstract Background Childhood cancer therapy may cause long‐term effects. This cross‐sectional study evaluated adulthood milestones in male childhood survivors (CCS). Methods The population comprised 252 CCS with 6 to 42 years of survival diagnosed at the Children’s Hospital Helsinki (1964–2000) age 0 17 years. Sex‐, age‐, and area residence–matched controls were randomly selected from Finnish national registries. Data on moving away parental home, marital status, offspring, adoption...
BACKGROUND:The use of ABO-incompatible liver transplants (ABO-ILTs) from deceased donors has become more common due to the shortage available donor livers and increased transplant waiting times. This retrospective study a national center at Helsinki University Hospital, Finland, aimed assess long-term outcomes pediatric between 1987 2022. MATERIAL AND METHODS:Sixteen (9.5%) 169 transplantations were ABO-ILTs. The median age transplantation was 5.0 (0.5-15.4) years. Reasons for ABO-ILTs acute...
Low physical activity is a well-recognized problem in pediatric solid organ transplant recipients; however, little known about the differences between groups. Physical performance testing was performed cohort of kidney, liver, and heart recipients.Fifty-one patients (54.9% boys), including 17 20 2 combined liver-kidney, 12 recipients, were tested at median age 11.5 (7.5-14.9) years. The results compared with control group, which consisted 425 healthy schoolchildren. test included six...
Abstract Chronic diseases are known to cause premature aging and frailty. Data about telomere length length‐regulating proteins after pediatric KTx scarce. Leukocyte gene expression level of eight telomere‐binding were analyzed in 20 recipients, childhood NBL survivors, nine healthy controls. The influence key clinical parameters on regulators was evaluated. the recipients tended be shorter (0.53 AU) than controls (0.64 but longer survivors (0.38 AU). There no significant difference between...
Background Pretransplant vaccination is generally recommended to solid organ transplant recipients. In infants with congenital nephrotic syndrome (CNS), the immune response hypothetically inferior other patients due young age and urinary loss of immunoglobulins, but data on immunization in severely children remain scarce. If effective, however, early CNS would clinically be advantageous. Methods We investigated serological vaccine responses seven who were immunized during nephrosis. Antibody...
Abstract Background The only effective treatment for severe forms of congenital nephrotic syndrome is nephrectomy and kidney transplantation (KT). Optimal timing unclear. Methods influence early (Group 1, n = 13) versus delayed 2, 10) on patient outcome was evaluated. key laboratory results, growth, number thromboembolic events infections, KT-related complications, ability to eat after KT were compared between the two groups. Results Patients in group 1 significantly younger at 2 (278 vs....
Abstract BKPyV is widely recognized in KTRs, but little known about rates of primary and secondary JCPyV exposure pediatric KTRs. We evaluated KTRs using antibody responses the first 12 months post‐transplant. Of 46 children transplanted between 2009 2014, 6 lacked any samples for serologic testing, leaving 40 study. JCPyV‐specific IgG IgM antibodies were measured a normalized VLP ELISA. Significant was defined as seroconversion, increasing levels >0.5 nOD units, or detection. recipients...