A5058965185- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Liver Disease and Transplantation
- Smoking Behavior and Cessation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Bowel Disease
- Asthma and respiratory diseases
- Child Nutrition and Feeding Issues
- Helicobacter pylori-related gastroenterology studies
- Air Quality and Health Impacts
- Microscopic Colitis
- Diversity and Career in Medicine
- Surgical Simulation and Training
- Abdominal Surgery and Complications
- Organ Transplantation Techniques and Outcomes
- Diverticular Disease and Complications
- Congenital gastrointestinal and neural anomalies
- Urological Disorders and Treatments
- Liver Diseases and Immunity
Helsinki University Hospital
2016-2025
University of Helsinki
2015-2025
ERN RARE-LIVER
2023
Helsinki Children's Hospital
2022
Hôpital Necker-Enfants Malades
2022
Assistance Publique – Hôpitaux de Paris
2022
American College of Surgeons
2016
Finnish Institute for Health and Welfare
2009-2011
National Institutes of Health
2011
Background and Aims: Outcomes after Kasai portoenterostomy (KPE) for biliary atresia remain highly variable unclear reasons. As reliable early biomarkers predicting KPE outcomes are lacking, we studied the prognostic value of FGF19. Approach Results: Serum liver specimens, obtained from patients (N=87) at or age-matched cholestatic controls (N=26) were included. concentration FGF19 bile acids, mRNA expression , key regulators acid synthesis related to histopathology. Immunohistochemistry in...
Background: Parenteral plant sterols (PSs) are considered hepatotoxic; however, liver PSs and their associations with injury in patients intestinal failure (IF) have not been reported. Materials Methods: We analyzed serum PS (avenasterol, campesterol, sitosterol, stigmasterol) concentrations ratios to cholesterol biochemical histologic damage children IF during (n = 7) parenteral nutrition (PN) after weaning off it 9), including vegetable oil–based lipid emulsions. Results: Liver...
Little is known on the mechanism of liver injury mediated by bile acids following Kasai portoenterostomy (KPE) in biliary atresia (BA). We sought to quantify individual serum acids, 7-alpha-hydroxy-4-cholesten-3-one (C4), and fibroblast growth factor 19 (FGF19) after KPE evaluate their prognostic utility transcriptomic regulation. Serum (n=244) specimens (n=105) prospectively obtained from BA patients (n=54) were included. Bile analyzed using mass spectrometry, gene expression with...
Abstract Background & Aims We aimed to evaluate the value of AST platelet ratio ( APRI ) and transient elastography TE as predictors liver histopathology in children with intestinal failure IF ). Methods Altogether 93 biopsies from 57 parenteral nutrition PN duration ≥3 months were analysed. measurement n = 46) performed at time biopsy. Results was caused by short bowel syndrome 75% patients. At biopsy, dependent patients 42) younger longer compared those weaned off 51) (2.2 vs. 7.6...
Background and aimsTreatment of complex perianal fistulas associated with Crohn's disease is challenging. In adults, seton drainage combined infliximab therapy has proven to be more effective than either one alone. Results following such treatment among pediatric patients have not been reported previously. The aim this study was describe outcomes after for in adolescents disease.
To analyze risk factors and prognostic significance of small bowel (SB) dilatation in children with short syndrome (SBS).In SBS, the remaining SB may dilate as part intestinal adaptation. The impact on parenteral nutrition (PN) dependence survival has not been studied systematically.SB diameter SBS (n = 61) was measured contrast series 169, median age 0.94, range 0.32-2.7 years) during 2002 to 2015, expressed millimeters (SB width) ratio L5 vertebra height ratio). Linear regression used...
We investigated noninvasive follow-up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children bilirubin <20 µmol/L PE (n = 39), Metavir stage was evaluated at protocol biopsies 83). PH defined as endoscopically confirmed esophageal varices or thrombocytopenia associated splenomegaly. The accuracy of biochemistry stiffness detecting analyzed by the area under receiving operating characteristic...
Cholangitis and bile lakes are incompletely understood complications after portoenterostomy (PE). We investigated relationships between recurrent cholangitis, lakes, clinical outcomes as well surgical management of lakes.In this retrospective observational single institution study medical records imaging studies all patients who had undergone PE for biliary atresia during 1987 to 2016 (N = 61) were reviewed. related occurrence cholangitis episodes with the presence intrahepatic patient...
Interleukin (IL)-8 (CXCL8), a chemokine involved in neutrophil recruitment, has been implicated ductular reaction and liver fibrogenesis. We studied serum IL-8 expression large biliary atresia (BA) cohort explored its prognostic pathophysiological potential. was assessed utilizing quantitative polymerase chain (qPCR), immunohistochemistry situ hybridization using an enzyme-linked immunosorbent assay, among 115 BA patients, 10 disease controls 68 normal controls. Results were correlated to...
Background: We aimed to quantify ductular reaction (DR) in biliary atresia using a neural network relation underlying pathophysiology and prognosis. Methods: Image-processing model was applied 259 cytokeratin-7–stained native liver biopsies of patients with 43 controls. The quantified total proportional DR (DR%) composed portal epithelium (BE%) parenchymal intermediate hepatocytes (PIH%). results were related clinical data, Sirius Red–quantified fibrosis, serum biomarkers, bile acids....
Most studies on lung function heritability have been conducted in smokers and non-smokers using cross-sectional study design. Smoking patterns may, however, confound the contribution of genetic factors. We investigated forced expiratory volume one second (FEV1), vital capacity (FVC), FEV1/FVC ratio longitudinally, excluding effects smoking. A sample never smoking female twins ( n = 374), aged 63–76 at baseline, answered health questionnaires attended spirometry years 2000 2003. Bivariate...
AbstractObjective. Few reports on choledochal malformations (CMs) in European populations exist. Materials and methods. The medical records of pediatric CM patients managed our nationwide referral center for hepatobiliary surgery between 1976 2013 (n = 38; 71% females) were reviewed. Results. Over follow-up time, the relative proportion fusiform CMs increased significantly (p 0.007) estimated total incidence rose from 1:128,000 to 1:38,000 0.017). Cystic (42%) presented at younger age than...
The main body of smoking behavior research has targeted primarily moderate and heavy smoking. This study aimed to define characteristics daily light examine the consistency this pattern. We examined among Finnish adult population using longitudinal data from Older Twin Cohort, collected in 1975, 1981, 1990. defined as fewer than 5 cigarettes/day 20 or more cigarettes per day. smokers comparison smokers, studied which baseline features predicted change pattern, described how pattern changed...
Concern over weight gain after smoking cessation has been hypothesized to discourage quit attempts and consequently reduce rates. The aim of this study was examine the association between status concerns among a population-based sample Finnish ever-smokers.Data were collected in conjunction with National FINRISK 2007 Study from 25- 74-yearold Finns. These analyses based on subsample 1,614 ever-smokers. Participants divided into 4 groups (daily smokers, occasional recent quitters, former...