A5006399639- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Nephrotoxicity and Medicinal Plants
- Clinical Nutrition and Gastroenterology
- Escherichia coli research studies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Viral gastroenteritis research and epidemiology
- Ion Transport and Channel Regulation
- Biomedical Research and Pathophysiology
- Adolescent and Pediatric Healthcare
- Genetic and Kidney Cyst Diseases
- Tuberous Sclerosis Complex Research
- Organ Transplantation Techniques and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Pregnancy and Medication Impact
- Electrolyte and hormonal disorders
- Infant Nutrition and Health
- Intestinal Malrotation and Obstruction Disorders
- Drug-Induced Hepatotoxicity and Protection
- Enterobacteriaceae and Cronobacter Research
University of Helsinki
2014-2024
Helsinki University Hospital
2015-2024
Weatherford College
2024
Helsinki Art Museum
2024
Amsterdam University Medical Centers
2019
University of Amsterdam
2019
Helsinki Children's Hospital
2003-2017
Great Ormond Street Hospital
2017
University College London
2017
Tampere University
1999-2000
Abstract Background Hemolytic uremic syndrome (HUS) is a multisystemic disease. In nationwide study, we characterized the incidence, clinical course, and prognosis of HUS caused by Shiga toxin (Stx)–producing Escherichia coli (STEC) strains with emphasis on risk factors, disease severity, long-term outcome. Methods The data pediatric patients from 2000 to 2016 were collected medical records. STEC isolates fecal cultures non-HUS same time period whole genome sequencing analysis. Results...
Abstract Background : Pediatric‐onset intestinal failure (IF) remains a severe illness with life‐threatening consequences. In this study, we analyzed single center's outcomes of IF over 3 decades. Methods All children who required parenteral nutrition (PN) >2 months or small‐intestinal resection ≥50% managed since 1984 were included for retrospective outcome analyses. Results total, 100 patients median PN duration 1.2 (interquartile range, 0.4–3.5) years identified. Causes short bowel...
Management of children with congenital nephrotic syndrome (CNS) is challenging. Bilateral nephrectomies followed by dialysis and transplantation are practiced in most centres, but conservative treatment may also be effective.We conducted a 6-year review across members the European Society for Paediatric Nephrology Dialysis Working Group to compare management strategies their outcomes CNS.Eighty (50% male) 17 tertiary nephrology units Europe were included (mutations NPHS1, n = 55; NPHS2, 1;...
Background. Improved management of growth impairment might have resulted in less retardation after pediatric kidney transplantation (KT) over time. We aimed to analyze recent longitudinal data KT comparison previous eras, its determinants, and the association with transplant outcome a large cohort transplanted children using from European Society for Paediatric Nephrology/European Renal Association Dialysis Transplant Registry. Methods. A total 3492 patients before 18 years 1990 2012 were...
Background High‐dose methotrexate (HD‐MTX) is potentially nephrotoxic. The feasibility of novel biomarkers to indicate renal injury due HD‐MTX infusion was studied in children with acute lymphoblastic leukemia (ALL). Procedure Markers for glomerular and tubular were evaluated prospectively after 20 ALL. Plasma creatinine, cystatin C, neutrophil gelatinase‐associated lipocalin (NGAL) measured 24–48 hr before MTX‐infusion 24, 36, 48, 72 starting the treatment, thereafter daily until MTX...
Shiga toxin-producing Escherichia coli (STEC) infection can cause mild to severe illness, such as nonbloody or bloody diarrhea, and the fatal hemolytic uremic syndrome (HUS). The molecular mechanism underlying variable pathogenicity of STEC is not fully defined so far. Here, we performed a comparative genomics study on large collection clinical strains collected from STEC-infected pediatric patients with without HUS in Finland over 16-year period, aiming identify bacterial genetic factors...
Abstract Background Associations between anthropometric measures and patient outcomes in children are inconsistent mainly based on data at kidney replacement therapy (KRT) initiation. We studied associations of height body mass index (BMI) with access to transplantation, graft failure, death during childhood KRT. Methods included patients < 20 years starting KRT 33 European countries from 1995–2019 weight recorded the ESPN/ERA Registry. defined short stature as standard deviation scores...
Abstract Aim Bilateral nephrectomy is commonly performed in patients with congenital nephrotic syndrome of the Finnish type. The optimal timing unclear. Methods Growth, thromboembolic events, infections, transplant‐related complications and ability to eat were compared between infants early (Group 1, n = 13) late 2, 10) nephrectomy. ‘Early’ was defined as at 7‐kg body weight followed by peritoneal dialysis ‘late’ ≥10 kg 3–4 weeks haemodialysis kidney transplantation. Patients until end first...
Abstract Background In Henoch–Schönlein nephritis (HSN), a risk factor for unfavorable outcome is prolonged proteinuria, but the value of renal biopsies in prognosis assessment debatable. Methods We evaluated serial from 26 HSN patients. Follow-up biopsy occurred at median 2.1 years after diagnostic biopsy. Patients formed two groups follow-up biopsy: patients without proteinuria (group I; n = 11) and with II; 15). Biopsies underwent evaluation according to three classifications:...
Adolescents with a kidney transplant (KT) require special attention during the transition of care. Few longitudinal studies have assessed effect models (TM) on patient outcomes. Between 1986 and 2013, 239 pediatric patients underwent KT in Finland, whom 132 been transferred to adult In 2005, TM was developed following international recommendations. We compared (PS) graft survival (GS) rates before after introduction TM. PS GS at 10 years were similar implementation (PS 85% 90% respectively,...
Abstract Background The pathophysiology of Henoch-Schönlein purpura (HSP) is still unclear, but several findings suggest that genetic factors may influence disease susceptibility. We aimed to perform a genome-wide association study (GWAS) in pediatric HSP patients with an emphasis on severe nephritis. Methods included 46 patients, 42 whom had undergone kidney biopsy. Forty-nine inflammatory bowel (IBD) served as autoimmune control group while Finnish bone marrow and blood donors represented...
Transplant patients need lifelong immunosuppressive medication, but this reduces their defense mechanisms, making them prone to viral infections and reactivations. We aimed clarify the prevalence clinical manifestations of human herpes virus 6 (HHV-6) infection in children after pediatric solid organ transplants. Clinical findings loads were compared between primary HHV-6 The study comprised 47 kidney, 25 liver, 12 heart transplant who underwent surgery from 2009 2014. antibodies analyzed...
Neonatal autosomal-recessive polycystic kidney disease (ARPKD) is associated with pulmonary hypoplasia and severe respiratory distress. There no published information on long-term lung function in ARPKD survivors.Pulmonary tests, including spirometry diffusion capacity, were performed a nationwide cohort of Finnish paediatric patients ARPKD. The annual incidence infections the need for permanent asthma medication also evaluated this population.Pulmonary 11 children surviving neonatal period...