A5046569845- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Health Systems, Economic Evaluations, Quality of Life
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Healthcare Policy and Management
- Central Venous Catheters and Hemodialysis
- Healthcare cost, quality, practices
- Renal Diseases and Glomerulopathies
- Adolescent and Pediatric Healthcare
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Pediatric Urology and Nephrology Studies
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Advanced Causal Inference Techniques
- Chronic Disease Management Strategies
- Global Health Care Issues
- Pregnancy and Medication Impact
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Erythropoietin and Anemia Treatment
- COVID-19 and healthcare impacts
Hôpital Necker-Enfants Malades
2025
Université Paris Cité
2025
Assistance Publique – Hôpitaux de Paris
2025
Inserm
2006-2025
Amsterdam University Medical Centers
2016-2025
University of Amsterdam
2016-2025
Public Health Service of Amsterdam
2018-2025
Amsterdam UMC Location University of Amsterdam
2015-2024
Leiden University Medical Center
2015-2024
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2024
Survival analyses are commonly applied to study death or other events of interest. In such analyses, so-called competing risks may form an important problem. A risk is event that either hinders the observation interest modifies chance this occurs. For example, when studying on dialysis, receiving a kidney transplant competes with Conventional methods for survival analysis ignoring event(s), as Kaplan–Meier method and standard Cox proportional hazards regression, be inappropriate in presence...
CKD prevalence estimation is central to management and prevention planning at the population level. This study estimated in European adult general investigated international variation by age, sex, presence of diabetes, hypertension, obesity. We collected data from 19 general-population studies 13 countries. stages 1–5 was defined as eGFR<60 ml/min per 1.73 m 2 , calculated CKD-Epidemiology Collaboration equation, or albuminuria >30 mg/g, 3–5 . age- sex-standardized 27 Member States...
The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined role patient characteristics, treatment factors, and country on risk with use ERA-EDTA Registry data patients receiving Europe from February 1, 2020, April 30, 2020. Additional all a were collected 7 countries encompassing 4298 patients. COVID-19–attributable calculated using propensity score–matched historic control 28 days...
In this article we introduce the concept of inverse probability treatment weighting (IPTW) and describe how method can be applied to adjust for measured confounding in observational research, illustrated by a clinical example from nephrology. IPTW involves two main steps. First, probability-or propensity-of being exposed risk factor or intervention interest is calculated, given an individual's characteristics (i.e. propensity score). Second, weights are calculated as score. The application...
Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group has produced comprehensive clinical practice guidelines for management of anaemia in CKD patients. These addressed all important points related to patients, including therapy with erythropoieis stimulating agents (ESA), iron therapy, ESA resistance and blood transfusion use. Because most were ‘soft’ rather than ‘strong’, because global need be adapted implemented into regional context where they are used, on behalf...
One of the most common requests that statisticians get from investigators are sample size calculations or justifications. The is number patients other experimental units included in a study, and determining required to answer research question one first steps designing study. Although statistical textbooks describe techniques for calculation, it often difficult decide which method use. There many formulas available can be applied different types data study designs. However, all these should...
Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed transplant dialysis patients with COVID-19. For analysis, were included who presented...
Abstract Diabetes, hypertension and cardiovascular disease have been listed as risk factors for severe coronavirus 2019 (COVID-19) since the first report of in January 2020. However, this did not mention chronic kidney (CKD) nor it provide information on relevance estimated glomerular filtration rate (eGFR) or albuminuria. As spread across globe, larger populations with greater granularity emerged. The recently published OpenSAFELY project analysed associated COVID-19 death 17 million...
This article summarizes the ERA-EDTA Registry's 2016 Annual Report, by describing epidemiology of renal replacement therapy (RRT) for end-stage disease (ESRD) in within 36 countries.In 2017 and 2018, Registry received data on patients undergoing RRT ESRD from 52 national or regional registries. In all, 32 registries provided individual patient 20 aggregated data. The incidence prevalence survival probabilities these were determined.In 2016, was 121 per million population (pmp), ranging 29...
Studies in cardiology often record the time to multiple disease events such as death, myocardial infarction, or hospitalization. Competing risks methods allow for analysis of first observed event and type event. They are also relevant if a specific is primary interest but competing may preclude its occurrence greatly alter chances observe it. We give non-technical overview concepts descriptive regression analyses. For statistics, cumulative incidence function most important tool. modelling,...
Abstract Objective To determine the global capacity (availability, accessibility, quality, and affordability) to deliver kidney replacement therapy (dialysis transplantation) conservative management. Design International cross sectional survey. Setting Society of Nephrology (ISN) survey 182 countries from July September 2018. Participants Key stakeholders identified by ISN’s national regional leaders. Main outcome measures Markers core components Results Responses were received 160 (87.9%)...
Congenital anomalies of the kidney and urinary tract (CAKUT) are leading cause ESRD in children, but proportion patients with individual CAKUT entities progressing to during adulthood their long-term clinical outcomes unknown. This study assessed age at onset renal replacement therapy (RRT) patient graft survival across entire range.Patients were compared age-matched who undergoing RRT for other disorders on basis data from European Renal Association-European Dialysis Transplant Association...