Delphine Kemlin
A5015055953- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Dialysis and Renal Disease Management
- Vaccine Coverage and Hesitancy
- Sepsis Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Intensive Care Unit Cognitive Disorders
- Complement system in diseases
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Respiratory Support and Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vasculitis and related conditions
- Healthcare cost, quality, practices
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Frailty in Older Adults
- Pneumocystis jirovecii pneumonia detection and treatment
- Emergency and Acute Care Studies
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
Université Libre de Bruxelles
2021-2024
Erasmus Hospital
2021-2024
Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed transplant dialysis patients with COVID-19. For analysis, were included who presented...
Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about replacement therapy (KRT) strategy during the pandemic. This study investigated association of type KRT with COVID-19 severity, adjusting for differences in individual characteristics.
Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery a large cohort of patients 3 months after their COVID-19 diagnosis.We analyzed data on diagnosed with from 1 February 2020 to 31 March 2021 the European Renal Association Database (ERACODA). The studied were survival, residence and functional mental health status (estimated by treating physician) diagnosis....
Lung transplant recipients (LTRs) are susceptible to severe Coronavirus Disease 2019 (COVID-19) and had lower immune responses primary acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) vaccination as compared the general population other solid organ recipients. As immunity induced by booster natural infection has increased since beginning of pandemic in population, acquired LTRs is not well documented. Humoral cellular SARS-CoV-2 was monitored February May 2023 30 that health...
Abstract Background Several guidelines recommend using the Clinical Frailty Scale (CFS) for triage of critically ill coronavirus disease 2019 (COVID-19) patients. This study evaluates impact CFS on intensive care unit (ICU) admission rate and hospital ICU mortality rates in hospitalized dialysis patients with COVID-19. Methods We analysed data diagnosed COVID-19 from European Renal Association Database. The primary outcome was secondary outcomes were until 3 months after diagnosis. Cox...
IntroductionComorbidities and immunosuppressive therapies are associated with reduced immune responses to primary COVID-19 mRNA vaccination in kidney transplant recipients (KTRs). In healthy individuals, prior SARS-COV-2 infection is increased vaccine responses, a phenotype called hybrid immunity. this study, we explored the potential influence of suppression on immunity KTRs.MethodsEighty-two KTRs, including 59 SARS-CoV-2-naive 23 SARS-CoV-2-experienced patients, were prospectively studied...
Fractional dosing of COVID-19 vaccines could accelerate vaccination rates in low-income countries. Dose-finding studies the mRNA vaccine BNT162b2 (Pfizer-BioNTech) suggest that a fractional dose induces comparable antibody responses to full people <55 years. Here, we report safety and immunogenicity regimen vaccine. REDU-VAC is participant-blinded, randomised, phase 4, non-inferiority study. Adults 18-55 years old, either previously infected or infection naïve, were randomly assigned receive...
Abstract Solid organ transplant (SOT) recipients are at enhanced risk of adverse outcomes following infectious challenges due to immunosuppressive treatment and additional comorbidities. Unfortunately, SOT also poor responders the key medical intervention preventing infection: vaccines. Here we performed a systems vaccinology study on cohort 59 kidney 31 lung who received mRNA Pfizer-BioNTech COVID-19 vaccine. Analyzing immunological status patients prior vaccination, were able identify...
The epidemiology, diagnostic methods and management of infectious complications after solid-organ transplantation (SOT) are evolving. aim our study is to describe current in the year following SOT risk factors for their development outcome. We conducted a retrospective adult recipients Belgian university hospital between 2018 2019. gathered demographic characteristics, comorbidities leading transplantation, clinical, microbiological, surgery-specific therapeutic data concerning episodes,...
Abstract Background Patients on kidney replacement therapy (KRT) are at very high risk of coronavirus disease 2019 (COVID-19). The triage pathway for KRT patients presenting to hospitals with varying severity COVID-19 illness remains ill-defined. We studied the clinical characteristics initial and subsequent hospital presentations impact patient outcomes. Methods European Renal Association Database (ERACODA) was analysed laboratory features 1423 either hospitalized or non-hospitalized those...
In the general population with coronavirus disease 2019 (COVID-19), obesity is associated an increased risk of mortality. Given typically observed paradox among patients on kidney function replacement therapy (KFRT), especially dialysis patients, we examined association mortality or living a transplant COVID-19. Data from European Renal Association COVID-19 Database (ERACODA) were used. KFRT diagnosed between 1 February 2020 and 31 January 2021 included. The Quetelet's body mass index (BMI)...
Abstract As solid organ recipients are at high risk of severe COVID-19 and respond poorly to primary SARS-CoV-2 mRNA vaccination, they have been prioritized for booster vaccination. However, an immunological correlate protection has not identified in this vulnerable population. We conducted a prospective monocentric cohort study 65 kidney transplant who received three doses BNT162b2 Associations between symptomatic breakthrough infection (BTI) vaccine responses, patient demographic clinical...
Abstract In the general population with COVID-19, male sex is an established risk factor for mortality, in part due to a more robust immune response COVID-19 women. Because patients on kidney function replacement therapy (KFRT) have impaired response, especially transplant recipients their use of immunosuppressants, we examined whether still mortality among KFRT COVID-19. From European Renal Association Database (ERACODA), who presented between February 1st, 2020, and April 30th, 2021. 1204...
Abstract In case of AAV with kidney involvement, physicians should explore anti‐GBM antibodies and be aware the possible sequential development AAV, especially MPO‐ANCA, glomerulonephritis. This disease history is associated a poor renal outcome, highlighting need for urgent diagnosis management.
1 Abstract Background The use of fractional dose regimens COVID-19 vaccines has the potential to accelerate vaccination rates in low-income countries. Dose-finding studies mRNA vaccine BNT162b2 (Pfizer-BioNTech) have suggested that a induces comparable antibody responses full, licensed people below 55 years old. Here, we report safety and immunogenicity regimen vaccine. Methods REDU-VAC is participant-blinded, randomised, phase 4, multicentre, non-inferiority study investigating safety,...