A5064560318- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Neurological Complications and Syndromes
- Polyomavirus and related diseases
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Organ and Tissue Transplantation Research
- COVID-19 and healthcare impacts
- Renal cell carcinoma treatment
- Pharmacological Effects and Toxicity Studies
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Hepatitis B Virus Studies
- Sepsis Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Renal and related cancers
University of Ljubljana
2014-2025
Ljubljana University Medical Centre
2015-2025
University Medical Center
2013-2024
Ministry of Health
2023
The Slovenian Research and Innovation Agency
2015
Blood Transfusion Centre of Slovenia
2010
Oregon Health & Science University
2008
Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about replacement therapy (KRT) strategy during the pandemic. This study investigated association of type KRT with COVID-19 severity, adjusting for differences in individual characteristics.
ABSTRACT Background The aim of this study was to identify trends in total, deceased donor (DD) and living (LD) kidney transplantation (KT) rates European countries. Methods Renal Association (ERA) Registry the Global Observatory on Donation Transplantation (GODT) databases were used obtain number KTs individual countries between 2010 2018. General population counts obtained from Eurostat or national bureaus statistics. KT rate per million (p.m.p.) average annual percentage change (APC)...
Primary glomerular disease (PGD) is a major cause of end-stage kidney (ESKD) leading to replacement therapy (KRT). We aimed describe incidence (trends) in individuals starting KRT for ESKD due PGD and examine their survival causes death.
ABSTRACT Background Preemptive kidney transplantation (PEKT) has better outcomes when compared with after dialysis. We aimed to examine trends in PEKT between 2000 and 2019 Europe provide an overview of associated policies, barriers initiatives. Methods Adult patients from 12 European countries who received a preemptive transplant were included. The representatives the registries providing these data questioned on initiatives around PEKT. Results Between 2019, 20 251 adults underwent [11 169...
Abstract Background and hypothesis Knowledge regarding access to first kidney transplantation (KT) subsequent KT in patients commencing replacement therapy (KRT) childhood is limited. Methods Using European Renal Association (ERA) Registry data, we investigated who started KRT below 20 years of age between 1978 2019. Access determinants first, second third were assessed using multivariable Cox regression. Results 12 623, 4077, 1186 included while awaiting KT, at median ages 13.8 (IQR:...
Background: Since the discovery of successful direct-acting antiviral (DAA) treatment, kidneys from hepatitis C virus (HCV) RNA-positive donors represent a new opportunity to expand organ donor pool for HCV-negative recipients. Case presentation: In this paper, we describe unique case transplantation an HCV genotype 3a-infected kidney into recipient who was highly sensitized, with virtual panel-reactive antibody level 99.96%. Prior transplantation, received DAA treatment...
Background. Simultaneous pancreas-kidney transplantation (SPKT) is the therapy of choice for selected patients with complicated type 1 diabetes mellitus and end-stage renal disease. Pancreas rescue allocation was implemented in Eurotransplant algorithms to increase organ utilization, concurrently facilitating supposedly inferior quality organs. The aim this study examine whether outcomes SPKT after allocation, which can either be recipient-oriented extended or competitive were as good...
Extracellular vesicle-bound DNA (evDNA) is an understudied extracellular vesicle (EV) cargo, particularly in cancer-unrelated research. Although evDNA has been detected urine, little known about its characteristics, localization, and biomarker potential for kidney pathologies. To address this, we enriched EVs from urine of well-characterized transplant recipients undergoing allograft biopsy, characterized their association to injury. The SEC-based method pure recipients, regardless the...
In this prospective, randomized, open-label, single-center study, we compared the efficacy and safety of two anti-interleukin-2 receptor monoclonal antibodies combined with triple immunosuppression.The adult recipients at least one human leukocyte antigen-mismatched deceased donor renal graft on cyclosporine microemulsion, mycophenolate mofetil, methylprednisolone were randomized to induction basiliximab or daclizumab, given in standard doses. An intent-to-treat analysis 1-year data assessed...
Background. Although survival of kidney regrafts is similar to that primary grafts, risk factors associated with regraft have not been defined clearly. The aim this study was investigate for outcome, including characteristics the previous and current transplant, time retransplant. Methods. In a historical cohort study, 966 176 repeat deceased donor graft recipients transplanted between January 1, 1990 December 31, 2004 were studied. Cox regression analysis used estimate loss hazard ratios...
Mesenchymal stem cell (MSCs) therapy has already been studied in kidney transplant recipients (KTRs), and the available data showed that it is safe well tolerated. The aim of this study was to evaluate safety efficacy autologous MSCs combination with standard KTRs biopsy-proven chronic active antibody-mediated rejection (AMR). Patients AMR received treatment bone marrow-derived (3 × 10 6 cells/kg iv) after completion were followed for up 12 months. primary endpoints by assessment adverse...
ABSTRACT Background Large international differences exist in kidney transplantation (KT) rates. We aimed to investigate which factors may explain the total, deceased donor and living KT rates over last decade. Methods experts from 39 European countries completed Kidney Transplantation Rate Survey on measures barriers their potential effect rate country. In analyses, were divided into low, middle high based at start of study period 2010. Results Experts low reported more frequently that they...
Antibody-mediated rejection (AMR) is a major cause of kidney graft failure. We aimed to analyze treatment and outcome AMR in national cohort 75 biopsy-proven acute (43 patients, 57%) or chronic active (32 43%) episodes between 2000 2015. The mean patients' age was 46 ± 16 years, the majority treated with plasma exchange, 4% received immunoadsorption 7% both. pulse methylprednisolone low-dose CMV hyperimmune globulin, 20% bortezomib 13% rituximab. Concomitant infection 40% patients. immediate...
Noroviruses are the leading cause of acute gastroenteritis, and they can affect humans all age groups. In immunocompromised patients, norovirus infections develop into chronic diarrhea or show prolonged asymptomatic virus shedding. Chronic frequently reported for solid organ transplant recipients, with rapid intrahost evolution seen. this report, we describe a case infection in an patient who was followed up over 5 years. The purpose study to specify chronically infected host identify...
Abstract Background We investigated 10-year trends in deceased donor kidney quality expressed as the risk index (KDRI) and subsequent effects on survival outcomes a European transplant population. Methods Time crude standardized KDRI between 2005 2015 by recipient age, sex, diabetic status country were examined 24 177 adult recipients seven countries. determined 5-year patient graft probabilities of death loss cohort (Cohort 1: 2005–06, Cohort 2: 2007–08, 3: 2009–10) quintile. Results The...
ABSTRACT Background The aim of this study was to provide an overview age, sex and primary renal disease (PRD) distribution among first kidney transplant recipients across Europe. Method European Renal Association (ERA) Registry database used obtain data on patients aged 20 years or older receiving their between 2010 2019 from 12 countries. numbers percentages in each PRD group were calculated by country, donor type year. Results In total, 99 543 adults received a transplant. Overall, 23% the...
Cardiovascular events (CVE) are the leading cause of mortality in kidney transplant recipients. The adverse effects long-term therapy with steroids on cardiovascular risk have motivated increasing interest steroid withdrawal (SW). objective this study was to compare incidences CVE and all-cause between patients who had undergone SW at 1 year posttransplant control continued steroids.A cohort 400 consecutive adult recipients a 1993 1998 qualified for late studied. At 188 underwent SW, whereas...
Objective: To examine current immunosuppressive regimens administered to kidney transplant recipients (KTRs) in South-eastern Europe. Methods: This was a 12-month, multicenter, non-interventional, prospective, observational study of adult de novo and maintenance KTRs. The primary endpoint identify the number, type, dosage trough concentrations (C0) medications. Results: Data were available for 1774 KTRs from five countries (Bulgaria [n = 109], Croatia 339], Romania 647], Serbia 434] Slovenia...
Abstract Objective To describe the long-term hemodialysis arteriovenous fistula (AVF) patency, incidence of AVF use, and nature complications surgery in patients after kidney transplantation. Patients methods We retrospectively analysed outcome all adult allograft recipients transplanted between January 1st, 2000 December 31, 2015 with a functional at time Follow-up was until 2019. Results included 626 patients. Median follow-up 4.9 years. One month transplantation estimated patency rate...
Systemic anticancer treatment (SAT) for metastatic renal cell carcinoma (mRCC) is associated with a variety of adverse events including hemorrhagic disorders and infections. A substantial number patients mRCC develop chronic kidney disease, which can progress to end-stage disease (ESKD) subsequently require replacement therapy, hemodialysis (HD). It currently not clear how often ESKD who are treated SAT life-threatening bleeding