A5103277928- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Chronic Disease Management Strategies
- Pharmacological Effects and Toxicity Studies
- Healthcare cost, quality, practices
- SARS-CoV-2 and COVID-19 Research
- Health Promotion and Cardiovascular Prevention
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Erythropoietin and Anemia Treatment
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Iron Metabolism and Disorders
- Body Composition Measurement Techniques
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Pharmaceutical Practices and Patient Outcomes
- Polyomavirus and related diseases
- Vitamin D Research Studies
Lithuanian University of Health Sciences
2013-2024
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
2003-2023
Tacrolimus (TAC) has a narrow therapeutic window and patient-specific pharmacokinetic variability. In our study, we analyzed the association between TAC exposure, metabolism, kidney graft outcomes (function, rejection, histological lesions). trough (C0), coefficient of variation (TAC CV), concentration/dose ratio (C/D), biomarkers related to injury molecule-1 (KIM-1) neutrophil gelatinase lipocalin (NGAL) were analyzed. We examined 174 patients who subjected triple immunosuppressive regimen...
Background and Objectives: The prospective study was conducted to evaluate humoral cellular immune responses after two doses of BNT162b2 (Pfizer-BioNTech) vaccine possible relation with other factors (medication, etc.) in kidney transplant patients. Materials Methods: Out 167 vaccinated patients, 136 agreed a follow-up visit three six weeks vaccination. Results: Only 39 patients (29%) developed antibody response against SARS-CoV-2 (≥35.2 binding units (BAU)/mL) full Multivariate binary...
With an increasing number of marginal donors, additional methods for the evaluation cadaveric kidney quality are required. This study aimed to evaluate pretransplant deceased donor serum (s) and urine (u) biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), injury molecule-1 (KIM-1), interleukin-18, C-X-C motif chemokine 10 (CXCL10) predicting early late graft function. In total, 43 donors 76 corresponding recipients were enrolled. Delayed function (DGF) occurred in 27.6%...
ABSTRACT Background Large international differences exist in kidney transplantation (KT) rates. We aimed to investigate which factors may explain the total, deceased donor and living KT rates over last decade. Methods experts from 39 European countries completed Kidney Transplantation Rate Survey on measures barriers their potential effect rate country. In analyses, were divided into low, middle high based at start of study period 2010. Results Experts low reported more frequently that they...
Introduction. Mortality rates for patients undergoing maintenance hemodialysis remain high. Published data regarding association between health-related quality of life (HRQOL) and mortality among are inconsistent. Very few published on the change in HRQOL over time as a predictor mortality. The aim this study was to assess whether it could be considered an independent patients. Material methods. This prospective observational enrolled 183 hemodialysis. measured annually 2004–2008 using...
Seroprevalence rates and molecular characterization of hepatitis E virus (HEV) prevalent in the Lithuanian human population has not yet been evaluated. Immunosuppressed individuals have recognized as a risk group for chronic due to HEV genotype 3 (HEV-3) infections. The objectives present study were determine prevalence anti-HEV antibodies among inflammatory bowel disease (IBD) patients solid organ transplant (SOT) recipients, isolate characterize strain population, investigate its capacity...
Background and Objectives: The safety effectiveness of vaccines are among the key priorities in COVID-19 pandemic management. Moreover, evidence-based data regarding vaccine immunogenicity can play an important role building trust community vaccination. aim this study was to investigate Pfizer-BioNTech healthcare workers one hospital, 21 days after first dose. Materials Methods: This conducted Hospital Lithuanian University Health Sciences between February March 2021. employees who arrived...
Background and Objectives: Vaccination is one means of SARS-CoV-2 prevention control. However, despite the effectiveness vaccination, adverse reactions continue to require vigilance monitoring. The researchers emphasize possibility that some reported side effects may be psychological in origin. Based on this hypothesis, main goal study was evaluate emotional dispositions healthcare workers who experienced emotions before vaccination after vaccination. Materials Methods: This conducted...
In the global threat of SARS-CoV-2, individuals undergoing maintenance dialysis represent a vulnerable population with an increased risk severe COVID-19 outcomes. Therefore, immunization against SARS-CoV-2 is essential component healthcare strategy for these patients. Existing data indicate that they tend to exhibit reduced immune response vaccines compared general population. Our study aimed assess both humoral and cellular responses following two doses anti-SARS-CoV-2 mRNA vaccine, ability...
Background and Objectives: Early improvements to graft function are crucial for good outcomes in kidney transplantation (kTx). Various factors can influence early function. This study aimed evaluate the pre- post-transplant hydration statuses of kTx recipients using bioimpedance analysis (BIA) lung ultrasonography (LUS) investigate status' relationship with transplanted during first year after transplantation. Materials Methods: observational prospective cohort included deceased Hospital...
The AUC (area under the concentration time curve) is considered pharmacokinetic exposure parameter best associated with clinical effects. Unfortunately, no prospective studies of outcomes have been conducted in adult transplant recipients to investigate properly potential benefits AUC(0–12) monitoring compared C0-guided therapy. aim present study was compare two methods, C0 (through level) and curve), for assessing cyclosporine tacrolimus concentrations. included 340 kidney recipients....
Erythropoietin stimulating agents had a long haul in Lithuania—we no epoetin till 1994 and there was intravenous iron 2001–2004. The aim of this study to assess the changes renal anemia control hemodialysis patients from early independence Lithuania nowadays evaluate link with hospitalization rates survival hemoglobin variability association mortality. In December each year since 1996 all centers have been visited data has collected using special questionnaires. history complicated; however,...
Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill patients acute kidney injury (AKI). In this study, we intended to assess fluid status using bioimpedance analysis (BIA) central venous pressure (CVP) measurement evaluate the association between hyperhydration hypervolemia of severe AKI. Materials Methods: A prospective study was conducted Hospital Lithuanian University Health Sciences Kauno Klinikos. Forty-seven treated at Intensive Care Unit...
Abstract Background and objectives : Vascular calcification (VC) is one of the factors associated with mortality in hemodialysis (HD) patients. The purpose study was to assess associations between prevalent VC disturbances calcium-phosphate metabolism as well changes vitamin D (25(OH)D), FGF 23 MGP levels evaluate possible impact these biomarkers on survival HD Methods population consisted 81 patients unit Hospital Lithuanian University Health Sciences Kaunas Clinics. A simple vascular score...
The aim of this study was to evaluate the risk factors for cardiovascular hospitalization in hemodialysis patients. Materials and methods. A cross-sectional cohort analysis during one census month (November) one-year follow-up rates 5 consecutive years (2002–2006) all end-stage renal disease patients hemodialyzed Kaunas region carried out. During month, we collected data on patient’s age sex, disability status, comorbidities, anemia control, malnutrition inflammation, calciumphosphorus...
Abstract Background and Aims The soluble urokinase plasminogen activator receptor (suPAR), a marker of podocyte injury, has been implicated in pathogenesis various kidney diseases, especially focal segmental glomerulosclerosis. It correlates to the activation level immune system. SuPAR predicted all course mortality hemodialysis patients, but was not tested as prognostic biomarker transplant patients. aim this study evaluate changes suPAR concentration after transplantation test its relation...