Elena Zakharova
A5034644063- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Pregnancy and preeclampsia studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- Maternal and fetal healthcare
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Graphite, nuclear technology, radiation studies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Diversity and Career in Medicine
- Sex and Gender in Healthcare
- Pancreatitis Pathology and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Nuclear and radioactivity studies
- Multiple Myeloma Research and Treatments
- Parathyroid Disorders and Treatments
- Tuberculosis Research and Epidemiology
- Human Health and Disease
- Peripheral Neuropathies and Disorders
Botkin Hospital
2016-2025
Ministry of Health of the Russian Federation
2018-2025
Moscow City Hospital No 29
2024
Regional Public Health Care Institution "City Hospital No. 5, Barnaul"
2024
Samara State Medical University
2005-2024
Research Center of Neurology
2024
City Clinical Hospital
2015-2023
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences
2023
Russian Medical Academy of Continuous Professional Education
2017-2022
Moscow State University of Medicine and Dentistry
2012-2022
Objectives To develop recommendations for the management of adult and paediatric lupus nephritis (LN). Methods The available evidence was systematically reviewed using PubMed database. A modified Delphi method used to compile questions, elicit expert opinions reach consensus. Results Immunosuppressive treatment should be guided by renal biopsy, aiming complete response (proteinuria <0.5 g/24 h with normal or near-normal function). Hydroxychloroquine is recommended all patients LN. Because...
Before the introduction of erythropoiesis-stimulating agents (ESAs) in 1989, repeated transfusions given to patients with end-stage renal disease caused iron overload, and need for supplemental was rare. However, widespread ESAs, it recognized that necessary optimize hemoglobin response allow reduction ESA dose economic reasons recent concerns about safety. Iron supplementation also found be more efficacious via intravenous compared oral administration, use has escalated years. The safety...
Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed transplant dialysis patients with COVID-19. For analysis, were included who presented...
Globally, the number of patients undergoing maintenance dialysis is increasing, yet throughout world there significant variability in practice initiating dialysis. Factors such as availability resources, reasons for starting dialysis, timing initiation, patient education and preparedness, modality access, well varied "country-specific" factors significantly affect experiences outcomes. As burden end-stage kidney disease (ESKD) has increased globally, also been a growing recognition...
The global nephrology community recognizes the need for a cohesive strategy to address growing problem of end-stage kidney disease (ESKD). In March 2018, International Society Nephrology hosted summit on integrated ESKD care, including 92 individuals from around globe with diverse expertise and professional backgrounds. attendees were 41 countries, 16 participants 11 low- lower-middle-income countries. purpose was develop strategic plan improve worldwide access by identifying prioritizing...
The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with ESKD. This paper is a summary of the ERA Annual Report 2020, also including comparisons among primary renal disease (PRD) groups.Data were collected from 52 national and regional registries 34 countries bordering Mediterranean Sea: 35 18 providing individual level 17 aggregated data. Using this data, KRT incidence prevalence, transplantation rates, expected remaining lifetimes...
Anemia associated with chronic kidney disease (CKD) often requires treatment recombinant human erythropoietin (EPO). Hypoxia-inducible factor-prolyl hydroxylase inhibitors (PHIs) stimulate endogenous EPO synthesis and induce effective erythropoiesis by non-EPO effects. GSK1278863 is an orally administered small-molecule PHI.Multicenter, single-blind, randomized, placebo-controlled, parallel-group study.Anemic non-dialysis-dependent patients CKD stages 3-5 (CKD-3/4/5 group; n=70) anemic...
Evidence-based cinical practice guidelines improve delivery of uniform care to patients with and at risk developing kidney disease, thereby reducing disease burden improving outcomes. These are not well-integrated into systems in most low- middle-income countries (LMICs). The KDIGO Controversies Conference on Implementation Strategies LMIC reviewed the current state knowledge order define a road map implementation guideline-based LMICs. An international group multidisciplinary experts...
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney key surrogates progression to exist specifically clinical trials. The International Society Nephrology convened multi-stakeholder meeting develop on this topic. A core group, experienced in design, conduct, adjudication trials, developed a database 64 randomized trials the 163 included relevant failure....
Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about replacement therapy (KRT) strategy during the pandemic. This study investigated association of type KRT with COVID-19 severity, adjusting for differences in individual characteristics.
ABSTRACT Background The aim of this study was to identify trends in total, deceased donor (DD) and living (LD) kidney transplantation (KT) rates European countries. Methods Renal Association (ERA) Registry the Global Observatory on Donation Transplantation (GODT) databases were used obtain number KTs individual countries between 2010 2018. General population counts obtained from Eurostat or national bureaus statistics. KT rate per million (p.m.p.) average annual percentage change (APC)...
Twelve March 2015 will mark the 10th anniversary of World Kidney Day (WKD), an initiative International Society Nephrology and Federation Foundations. Since its inception in 2006, WKD has become most successful effort ever mounted to raise awareness among decision-makers general public about importance kidney disease. Each year reminds us that disease is common, harmful treatable. The focus on chronic (CKD) disadvantaged populations. This article reviews key links between poverty CKD...
Abstract Monoclonal gammopathy of renal significance (MGRS) is a recognized clinical entity. Literature regarding treatment and its outcomes in MGRS sparse due to the rarity misdiagnosis MGRS. We retrospectively analyzed 280 adults with an diagnosis from 2003 2020 across 19 centers 12 countries. All cases required biopsy for pathological Amyloidosis‐related (MGRS‐A) was present 180 patients; nonamyloidosis (MGRS‐NA), including broad spectrum pathologies, diagnosed 100 patients. The median...
How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)?MAR services, and hence treatments for infertile couples, were stopped most European countries a mean of 7 weeks.With outbreak Europe, non-urgent medical care was reduced by local authorities preserve health resources maintain social distancing. Furthermore, ESHRE other societies recommended postpone ART pregnancies as 14 March 2020.A...
<h3>Abstract</h3> <b>Objective</b> To determine variability in interpretation of chest radiographs among tuberculosis specialists, radiologists, and respiratory specialists. <b>Design</b> Observational study. <b>Setting</b> Tuberculosis disease services, Samara region, Russian Federation. <b>Participants</b> 101 clinicians involved the diagnosis management pulmonary diseases. <b>Main outcome measures</b> Interobserver intraobserver agreement on 50 digital radiographs, using a scale poor to...
Mutations in several potassium channel subunits have been associated with rare forms of atrial fibrillation. In order to explore the role channels inherited typical arrhythmia, we screened a cohort patients from referral clinic for mutations subunit genes implicated arrhythmia. We sought determine if KCNJ2 and KCNE1-5 are common cause Serial lone fibrillation or hypertension were enrolled between June 1, 2001 January 6, 2005. Each patient underwent standardized interview physical...