A5024593129- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal and Vascular Pathologies
- Blood Pressure and Hypertension Studies
- Erythropoietin and Anemia Treatment
- Chronic Kidney Disease and Diabetes
- Pancreatitis Pathology and Treatment
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Long-Term Effects of COVID-19
- Urinary Tract Infections Management
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Cerebrovascular and Carotid Artery Diseases
- Folate and B Vitamins Research
- COVID-19 and Mental Health
- Diagnosis and treatment of tuberculosis
- Hemoglobinopathies and Related Disorders
- Infectious Disease Case Reports and Treatments
- Dermatological and Skeletal Disorders
- Vasculitis and related conditions
Medical University of Sofia
2008-2025
Multiprofile Hospital for Active Treatment in Neurology and Psychiatry St. Naum
2024
"Hadji Dimitar" Hospital
2023
Weatherford College
2022
Alexandrovska Hospital
2005-2021
Evidence-based cinical practice guidelines improve delivery of uniform care to patients with and at risk developing kidney disease, thereby reducing disease burden improving outcomes. These are not well-integrated into systems in most low- middle-income countries (LMICs). The KDIGO Controversies Conference on Implementation Strategies LMIC reviewed the current state knowledge order define a road map implementation guideline-based LMICs. An international group multidisciplinary experts...
Urinary tract infections (UTIs) are among the most prevalent bacterial infections, with Klebsiella pneumoniae emerging as a significant multidrug-resistant pathogen, particularly in healthcare settings. The frequent utilization of β-lactams and fluoroquinolones has contributed to reduced clinical application trimethoprim-sulfamethoxazole (TRS). Nevertheless, this use may have preserved its efficacy second-line therapy. aim study is determine whether TRS can be cost-effective long-term...
Probiotics have been used to prevent antibiotic-associated diarrhea (AAD), but practical guidelines are sparse. This trial evaluated the efficacy and safety of a high-dose, multistrain probiotic mix (Sinquanon), specially designed for prevention AAD in adults.
AIM: The aim of the study is to make a retrospective analysis incidence AV fistulas after renal biopsy (RB) native and transplanted kidney.MATERIALS AND METHODS: Five hundred sixteen (516) RB were analyzed. One twenty nine (129) kidneys performed in Clinic Nephrology (CN), 190 transplantation (CNT) 197 kidney biopsies from same clinic. Biopsy technique type Gun with needle 14G, 16 18 G was used CN, CNT needles 16G. Doppler ultrasound made for A-V diagnosis.RESULTS: 0.8%. frequency registered...
In this prospective study, we assessed biomarkers of inflammation (IL-6 and SAA) from the serum 120 COVID-19 patients, whom 70 had chronic kidney disease. All samples were taken at emergency-department (ED) admission. Our goal was to relate results death acute injury. patients underwent chest computer tomography estimate severity score (0–5), which performed hospital Finally, also evaluated in a healthy control group non-COVID-19-CKD patients. IL-6 SAA statistically different between...
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant health concern, particularly for patients with chronic kidney disease (CKD). This study investigates the long-term outcomes individuals CKD who were infected COVID-19, focusing on their status over three-year period post-infection. Data collected from both and non-CKD survived infection followed three years as part research impact, prognosis, consequences COVID-19 in patients. In this prospective cohort study, we analyzed clinical...
Iron is an essential element for the living body. It well known that iron homeostasis disorders are important in two ways--its deficiency and its overload lead to several pathologies.We measured 17 patients with anemia (IDA); 19 of chronic diseases (ACD); 15 ischemic stroke (IS). The results were compared a previously selected control group. For evaluation metabolism status, we serum levels, ferritin, soluble transferrin receptors. inflammation, interleukin-6 hsCRP measured. Serum hepcidin...
Regarding COVID-19 infection, Bulgaria has one of the lowest rates vaccination in Europe, and its COVID-19-related mortality rate been highest European Union. Chronic kidney disease (CKD)-COVID-19 patients are at higher risk developing acute injury (AKI) death after hospital admission. This single-center prospective cohort study from included 120 in-patient subjects whom 70 had CKD 50 normal renal function. Diabetes mellitus, hypertension, obesity, cardiovascular were statistically more...
In a prospective, observational, non-interventional, single-center study, we assessed various plasma and urinary biomarkers of kidney injury (neutrophil gelatinase-associated Lipocain [NGAL], kidney-injury molecule-1 [KIM-1], interleukin-18 [IL-18]); inflammation (IL-6, C-reactive protein [CRP]); plus angiotensin converting enzyme 2 (ACE2) in 120 COVID-19 patients (of whom 70 had chronic disease (CKD) at emergency-department (ED) admission). Our aim was to correlate the with outcomes (death,...
Parvovirus B19, a member of the Parvoviridae family, is known for causing various clinical manifestations, including erythema infectiosum and arthropathy. However, its association with pure red cell aplasia (PRCA) following solid organ transplantation remains relatively uncommon. We present case report detailing occurrence B19-induced PRCA in patient who underwent kidney – 48 years old man had history hypertension gout received from living donor. The presented clinic severe anemia,...
When angiotensin-converting enzyme inhibitor/angiotensin receptor blocker-treated patients present with SARS-CoV-2 infection there is a debate to know whether renin-angiotensin-aldosterone (RAAS) blockers should be stopped or not. We conducted prospective observational study in Bulgarian COVID-19-infected without chronic kidney disease (CKD) assess maintenance RAAS blocker therapy has an impact on and its complications. included 120 in-patient COVID-19 subjects, of whom 70 had CKD 50 normal...
Chronic kidney disease (CKD) is a condition that involves 10% - 15% of population worldwide, which increases the risk cardio-vascular diseases (CVD). one main reasons for illness and mortality in world. serious health problem caused by involvement large number patients with injury, especially industrial countries. Among this are living longer elderly persons, such as diabetes mellitus type 2, hypertension, diseases.We evaluated 63 on chronic dialysis at Dialysis Centre University...
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and a leading cause of chronic kidney disease renal failure. However, Bulgarian population has limited epidemiological data biomarkers for IgAN. In this retrospective monocentric analysis, we investigated all patients with biopsy-proven IgAN over 10 years in tertiary institution. From analysis 762 biopsies, diagnosis primary was established 125, an average age 35.94 ± 11.91 years. Our study aimed to assess clinical...
A common complication in patients with chronic kidney disease (CKD) and the presence of COVID-19 infection is acute injury (AKI). In 9 out 10 cases, mortality occurs presenting AKI. The aim this study to determine whether there are sufficiently informative biomarkers for early prediction these complications.
IgA nephropathy (IgAN) represents the most prevalent form of glomerulonephritis, particularly in developed nations. Despite high prevalence this condition, treatment options remain a topic debate. Recent years have witnessed emergence numerous clinical trials proposing specific treatments. In Bulgaria, patients still limited access to novel treatments, prompting us share our experiences with existing therapeutic modalities and advocate for enhanced knowledge evolution.
Abstract Background and Aims IgA nephropathy (IgAN) represents a significant global health concern, contributing substantially to chronic kidney disease renal failure. Despite its widespread impact, the Bulgarian population lacks comprehensive epidemiological data specific biomarkers for IgAN. This decade-long retrospective study, conducted at tertiary Nephrology Clinic in Bulgaria, aims explore clinical characteristics serum levels of BAFF APRIL biopsy-confirmed IgAN patients healthy...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Nikolova-Vlahova M, Kamburova Hristova J, et al. Biclonal myeloma in renal failure. Central European Journal of Immunology. 2020;45(1):122-124. doi:10.5114/ceji.2020.94714. APA Nikolova-Vlahova, M., Kamburova, Hristova, J., Vasileiou, D., Bogov, B., & Krasteva, R. (2020). Immunology, 45(1), 122-124. https://doi.org/10.5114/ceji.2020.94714 Chicago Milena K., Miroslava Julieta Dimitrios Boris Rumiana and Evgeni...
The aim of our study was to quantify serum hepcidin levels in Bulgarian patients with chronic kidney disease (CKD).Expected high values peptide hormones might provide a new therapeutic choice for anemia disease.We looked correlation between and some iron metabolism parameters CKD patients.Results: sandwich ELISA is highly specific hepcidin-25.We found statistically significant differences the control group, stages II IV stage V (on dialysis): 12.7±8.7μg/L,90.74±21.1μg/L,and...
AIM: Previous studies showed that patients with chronic kidney disease (CKD) > 2 dergee had increased intima-media thickness (IMT). We evaluate the relationship between IMT and parameters for renal function.METHODS: 130 subjects were examined – 66 CKD, 44 without as well 20 healthy volunteers. The first group- CKD creatinine clearance (CrCl) over ml/min below 90 ml/min. second group included pts. normal function, CrCl All hypertension.  two groups streamed into subgroups: vascular...
Primary hyperparathyroidism (PHPT) is unregulated hyperproduction of parathyroid hormone (PTH), inadequate to serum calcium levels.High PTH levels are associated with hypercalciemia, hypercalciuria and hyperphosphaturia, increased bone absorbtion decreased mass density, gastric hyperacidity the development peptic ulcers, tissue deposition calium phosphate pancreatitis, nephrocalcinosis vascular calcifications.The kidney involvement in PHPT with: nephrolithiasis, nephrocalcinosis, chronic...