A5011332075- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Pediatric health and respiratory diseases
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Human Health and Disease
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Food Allergy and Anaphylaxis Research
- Nosocomial Infections in ICU
- Vitamin C and Antioxidants Research
- Lung Cancer Research Studies
- Heart Rate Variability and Autonomic Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Infectious Diseases and Tuberculosis
- Advanced Glycation End Products research
Medical University of Sofia
2012-2024
University Hospital St. Ivan Rilski
2024
Medical University Plovdiv
2013
Istituto Giannina Gaslini
1998
Ceftaroline, the active form of prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated community-acquired pneumonia (CAP), including Streptococcus pneumoniae and common Gram-negative pathogens. FOCUS 1 randomized, double-blinded, Phase III study that was conducted to evaluate efficacy safety fosamil in treating patients CAP. The primary objective determine non-inferiority [lower limit 95% confidence interval (CI) ≥ −10%]...
Background: Post-COVID-19 syndrome (PCS) is defined as the persistence of symptoms 3 months after acute SARS-CoV-2 infection. The long-term prevalence and clinical progression PCS has not been established. Our aim was to investigate in patients, explore degree physical activity, according fatigue severity score, analyze its association with basic cardio-pulmonary exercise testing (CPET) parameters. Methods: A total 192 subjects history SARSCoV-2 infection were included. They filled Chronic...
Probiotics have been used to prevent antibiotic-associated diarrhea (AAD), but practical guidelines are sparse. This trial evaluated the efficacy and safety of a high-dose, multistrain probiotic mix (Sinquanon), specially designed for prevention AAD in adults.
Single microbial pathogens or host-microbiome dysbiosis are the causes of lung diseases with suspected infectious etiology. Metagenome sequencing provides an overview microbiome content. Due to rarity most granulomatous collecting large systematic datasets is challenging. Thus, single-patient data often can only be summarized visually.To increase information gain from a single-case metagenome analysis we suggest quantitative and qualitative approach.The 16S metagenomic results 7 patients...
The presence of abnormal heart rate recovery (HRR) and chronotropic incompetence (CI) suggests autonomic dysfunction (AD) is associated with diminished physical activity increased cardio-vascular (CV) risk.Our aim to analyse the correlation between AD airflow obstruction - forced expiratory volume in 1s (FEV1), dynamic hyperinflation (DH) disease prognosis BODE ... index (BMI; Obstruction FEV1;Dyspnea mMRC;E exercise capacity) non-severe COPD patients without overt CV comorbidities.We used...
Chronic obstructive pulmonary disease (COPD) augments the likelihood of having left ventricular diastolic dysfunction (LVDD)–precursor heart failure with preserved ejection fraction (HFpEF). LVDD shares overlapping symptomatology (cough and dyspnea) COPD. Stress induced is indicative masked HFpEF. Our aim was to evaluate predictive value inflammatory, oxidative stress, cardio-pulmonary echocardiographic parameters at rest for diagnosis stress in non-severe COPD patients, who complain...
Abstract Background: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms. Aim: To identify phenotypes using cluster analysis in moderate to severe bronchial and compare differences clinical, physiological, immunological inflammatory data between the clusters. Patients methods: Forty adult patients with out of exacerbation were included. All underwent assessment,...
<b>Introduction:</b> Different approaches have been developed for better definition of asthma phenotypes, that would benefits from target treatment. The use complex data is step to understanding asthma. <b>Aim:</b> To identify distinct clusters based on pre-selected clinical, functional and inflammatory variables compare the serum levels IL-5, IL-6 IL-8 between them. <b>Methods:</b> Adult patients with moderate severe were included (n=70). Data about onset, exacerbations, symptoms, control,...
Background: Sarcoidosis is a chronic inflammatory disease that can affect multiple organs. The aetiology of sarcoidosis not fully understood, but there increasing evidence the microbiome may play role. blood collection microorganisms live in bloodstream. It complex and dynamic community influenced by variety factors, including host’s lifestyle pathology. Recent studies have shown people with alterations their microbiome. These include changes diversity, richness, evenness microbial...
AbstractIn allergic asthma, there is convincing evidence that changes in eosinophil and lymphocyte state of activation blood may reflect disease activity. We evaluated whether simple or counts atopic children with asthma could the degree sensitization. Seventy-six asthmatic children, sensitized to house dust mites (HDM), stable conditions at time study, 53 sex- age-matched controls (CTR) were studied.As compared CTR, patients showed higher numbers percentages (p < 0.001) but similar...
ORAL ABSTRACT SESSION 1—Asthma: from mechanisms to managementO01 Serum IL-1RL1-A levels predict an eosinophilic subtype of asthma in preschool wheezing childrenM. E. Ketelaar1, K. Van De Kant2, F. N. Dijk1, M. Klaassen3, Grotenboer4, C. Nawijn4, Dompeling2, G. H. Koppelman1 1University Medical Center Groningen, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD (GRIAC), The Netherlands; 2Department Pediatric Pulmonology, School Public Health Primary Care (CAPHRI),...
<b>Introduction:</b> The role of IL-6 in the pathogenesis bronchial asthma (BA) is still unclear. has been viewed as an inflammatory marker, but recent studies suggest that it also a regulatory cytokine. <b>Aim:</b> To analyse serum levels adult patients (Pts) with moderate to severe BA (AP). <b>Method:</b> We have evaluated 10 healthy controls (HC) and 30 AP out exacerbation - 20 chronic rhinitis (CR+) without (CR-). Among CR+ 16 Pts were allergic (AR) 4 non-allergic (NR). Serum measured by...
Isoniazid (H; INH) is an important first-line drug for the treatment of active tuberculosis (TB) and latent TB infection because its potent early bactericidal activity against Мycobacterium tuberculosis. Currently, resistant to INH, alone or in combination with other drugs, most common type drug-resistant TB. Epidemiology INH-resistant TB, molecular mechanisms resistance, current methods diagnosis therapeutic regimens this form are presented. Studies last years have shown that resistance INH...
Asthma-COPD overlap (ACO) is a disorder that combines clinical signs of bronchial asthma and COPD – fixed airways obstruction and/or significant reversibility the obstruction, rapid progression, poor quality life, higher mortality, frequent severe exacerbations compared to alone. The aim our study determine neutrophil gelatinase-associated lipocalin (NGAL) interleukin-6 (IL-6) plasma levels analyze their association with peripheral eosinophilia patients asthma-COPD (ACO), Chronic obstructive...
The receptor for advanced glycation-end products (RAGE) is a multiligand associated with inflammatory conditions. RAGE pivotal to the effects of renin-angiotensin system (RAS) and takes part in multiorgan injury COVID-19 patients. Activation sustains inflammation oxidative stress common comorbidities severe COVID-19. Thus, might be major player its gene polymorphism may predispose
Vitamin D helps our immunity to fight viruses and bacteria, thus reducing the risk of respiratory infections. It suppresses excessive or dysfunctional activities prevents autoimmune diseases. In animal models vitamin increases ACE2 on cell surface, so its protection may not apply COVID-19 since SARS-CoV-2 enters human cells by binding ACE2. On other hand, might make less severe, as it protects against lung damage. Observational ecological studies are controversial regarding association vit...
<b>Introduction:</b> The long-term goals of asthma management are to achieve good control symptoms and minimize future risk exacerbations. <b>Aim:</b> To identify predictors frequent severe exacerbations in patients with moderate asthma. <b>Methods:</b> Adult were included (n=70). They split into two groups: Group 1 (n=50) ≤ exacerbation the previous year; 2 (n=20) > year. Demographical, clinical anthropometrical data collected. Symptoms assessed (ACQ). Lung function, absolute blood...
<b>Goal:</b> To investigate plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) and IL-6 their association with the peripheral eosinophilia exacerbations patients ACO, COPD A. <b>Material Methods:</b> We studied 81 broncho-obstructive diseases out off exacerbation: A (n=26), COPD(n=25) AC?(n=30). determined NGAL, IL-6(ELISA) blood eosinophils count(Eo). measured respiratory function bronchodilator responsiveness by standard spirometry. <b>Results:</b> were significantly...
<b>Goal:</b> To investigate plasma levels of NGAL (neutrophil gelatinase-associated lipocalin) and IL-6 their association with the peripheral eosinophilia exacerbations patients ACO, COPD A. <b>Material Methods:</b> We studied 81 broncho-obstructive diseases out off exacerbation: A (n=26), COPD(n=25) AC?(n=30). determined NGAL,IL-6(ELISA) blood eosinophils count(Eo). measured respiratory function bronchodilator responsiveness by standard spirometry. <b>Results:</b> were significantly...