A5040976154- Protein Kinase Regulation and GTPase Signaling
- Venomous Animal Envenomation and Studies
- Lipid Membrane Structure and Behavior
- Metabolomics and Mass Spectrometry Studies
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Inflammatory mediators and NSAID effects
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Fatty Acid Research and Health
- Healthcare and Venom Research
- Mass Spectrometry Techniques and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Hemoglobin structure and function
- Receptor Mechanisms and Signaling
- Protein Structure and Dynamics
- Atherosclerosis and Cardiovascular Diseases
- Surfactants and Colloidal Systems
- Ion channel regulation and function
- Skin Protection and Aging
- Biomedical Research and Pathophysiology
- Alcohol Consumption and Health Effects
University of California, San Diego
2016-2025
Pennsylvania State University
2013-2025
La Jolla Alcohol Research
2024
University College London
2023
Kilimanjaro Christian Medical Centre
2023
University of Minnesota
2019
Oregon Health & Science University
2019
UC San Diego Health System
2019
University of Michigan–Ann Arbor
2017-2018
University of Wisconsin–Madison
2008-2017
The focus of the present study was to define human plasma lipidome and establish novel analytical methodologies quantify large spectrum lipids. Partial lipid analysis is now a regular part every patient's blood test physicians readily regularly prescribe drugs that alter levels major lipids such as cholesterol triglycerides. Plasma contains many thousands distinct molecular species fall into six main categories including fatty acyls, glycerolipids, glycerophospholipids, sphingolipids,...
The LIPID MAPS Structure Database (LMSD) is a relational database encompassing structures and annotations of biologically relevant lipids. Structures lipids in the come from four sources: (i) Consortium's core laboratories partners; (ii) identified by experiments; (iii) computationally generated for appropriate lipid classes; (iv) manually curated BANK, LIPIDAT other public sources. All LMSD are drawn consistent fashion. In addition to classification-based retrieval lipids, users can search...
A comprehensive and standardized system to report lipid structures analyzed by MS is essential for the communication storage of lipidomics data. Herein, an update on both LIPID MAPS classification shorthand notation presented categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), Sterols (ST). With its major changes, i.e., annotation ring double bond equivalents number oxygens, updated facilitates reporting newly delineated oxygenated species as well....
We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO– autoantibodies). now demonstrate that those EO– were originally selected for binding copper-oxidized lipoproteins (CuOx-LDL), also bound both the protein and lipid moieties CuOx-LDL. The same showed specific products 1-palmitoyl-2-arachidonoyl-phosphatidylcholine (OxPAPC) phospholipid, 1-palmitoyl-2-(5-oxovaleroyl)-phosphatidyl-choline (POVPC),...
The lipocortins are a group of proteins that have been reported to inhibit phospholipase A2 by direct interaction with enzyme. Two which identified as lipocortin on the basis inhibition activity recently cloned and sequenced. These shown be identical calpactins, membrane cytoskeletal serving major substrates tyrosine protein kinases. We now found two forms calpactin (I II) porcine pancreatic in an assay using Escherichia coli cells or extracted phospholipid vesicles substrate, but only when...
Apoptosis is recognized as important for normal cellular homeostasis in multicellular organisms. Although there have been great advances our knowledge of the molecular events regulating apoptosis, much less known about receptors on phagocytes responsible apoptotic cell recognition and phagocytosis or ligands cells mediating such recognition. The observations that are under increased oxidative stress oxidized low-density lipoprotein (OxLDL) competes with macrophage binding suggested...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe size, shape, and hydration of nonionic surfactant micelles. Triton X-100Robert J. Robson Edward A. DennisCite this: Phys. Chem. 1977, 81, 11, 1075–1078Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/j100526a010https://doi.org/10.1021/j100526a010research-articleACS PublicationsRequest reuse permissionsArticle Views3086Altmetric-Citations359LEARN...
A novel Ca2+-independent phospholipase A2 (PLA2) has recently been purified from the murine macrophage-like cell line P388D1 (Ackermann, E. J., Kempner, S., and Dennis, A.(1994) J. Biol. Chem. 269, 9227-9233). This enzyme is now shown to be inhibited by palmitoyl trifluoromethyl ketone (PACOCF3), arachidonyl (AACOCF3), a bromoenol lactone (BEL). Both PACOCF3 AACOCF3 were found inhibit macrophage PLA2 in concentration-dependent manner. was ~4-fold more potent than AACOCF3, with IC50 values of...