Bruno Mégarbane
A5053916099- Poisoning and overdose treatments
- Cardiac Arrest and Resuscitation
- Forensic Toxicology and Drug Analysis
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Opioid Use Disorder Treatment
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Pharmacological Effects and Toxicity Studies
- Alcoholism and Thiamine Deficiency
- Pneumonia and Respiratory Infections
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Thermal Regulation in Medicine
- Pesticide Exposure and Toxicity
- Cardiac electrophysiology and arrhythmias
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Veterinary Pharmacology and Anesthesia
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Sedative Agents
Assistance Publique – Hôpitaux de Paris
2016-2025
Inserm
2016-2025
Université Paris Cité
2016-2025
Hôpital Lariboisière
2016-2025
Optimisation Thérapeutique en Neuropsychopharmacologie
2012-2024
Sorbonne Paris Cité
2012-2024
Hôpital Fernand-Widal
2014-2024
Hypertension pulmonaire : physiopathologie et innovation thérapeutique
2018-2023
Mère et Enfant en Milieu Tropical
2023
Générale de Santé
2022-2023
There is a need for close communication with relatives of patients dying in the intensive care unit (ICU). We evaluated format that included proactive end-of-life conference and brochure to see whether it could lessen effects bereavement.
The Surviving Sepsis Campaign recommends targeting a mean arterial pressure of at least 65 mm Hg during initial resuscitation patients with septic shock. However, whether this blood-pressure target is more or less effective than higher unknown.In multicenter, open-label trial, we randomly assigned 776 shock to undergo either 80 85 (high-target group) 70 (low-target group). primary end point was mortality day 28.At 28 days, there no significant between-group difference in mortality, deaths...
The timing of renal-replacement therapy in critically ill patients who have acute kidney injury but no potentially life-threatening complication directly related to renal failure is a subject debate.
Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy hydrocortisone plus fludrocortisone or drotrecogin alfa (activated), which can modulate response, would improve clinical outcomes patients septic shock.
Three anatomical sites are commonly used to insert central venous catheters, but insertion at each site has the potential for major complications.
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
<h3>Context</h3>Based on concerns about the risk of infection, jugular site is often preferred over femoral for short-term dialysis vascular access.<h3>Objective</h3>To determine whether catheterization decreases nosocomial complications compared with catheterization.<h3>Design, Setting, and Patients</h3>A concealed, randomized, multicenter, evaluator-blinded, parallel-group trial (the Cathedia Study) 750 patients from a network 9 tertiary care university medical centers 3 general hospitals...
Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired is low. We aimed to determine relationship between pneumonia, as compared influenza pneumonia or no viral infection, and VA-LRTI.Multicenter retrospective European cohort performed in 36 ICUs. All adult receiving invasive mechanical ventilation > 48 h were eligible if they had: at ICU admission. VA-LRTI,...
Rationale: Frontline healthcare providers (HCPs) during the coronavirus disease (COVID-19) pandemic are at high risk of mental morbidity.Objectives: To assess prevalence symptoms anxiety, depression, and peritraumatic dissociation in HCPs.Methods: This was a cross-sectional study 21 ICUs France between April 20, 2020, May 21, 2020. The Hospital Anxiety Depression Scale Peritraumatic Dissociative Experience Questionnaire were used. Factors independently associated with reported health...
Abstract Aims Out-of-hospital cardiac arrest (OHCA) without return of spontaneous circulation (ROSC) despite conventional resuscitation is common and has poor outcomes. Adding extracorporeal membrane oxygenation (ECMO) to cardiopulmonary (extracorporeal-CPR) increasingly used in an attempt improve Methods results We analysed a prospective registry 13 191 OHCAs the Paris region from May 2011 January 2018. compared survival at hospital discharge with extracorporeal-CPR identified factors...
In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in COVID-19 pandemic. We report ECMO network organisation and outcomes during first wave of pandemic.In this multicentre cohort study, we present an analysis all adult patients with laboratory-confirmed SARS-CoV-2 infection ARDS requiring who were admitted to 17 Paris intensive care units between March 8 June 3,...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
The benefit of high-dose dexamethasone and oxygenation strategies vs standard care for patients with severe acute hypoxemic respiratory failure (AHRF) caused by COVID-19 pneumonia is debated.To assess the compared dexamethasone, to high-flow nasal oxygen (HFNo2) or continuous positive airway pressure (CPAP) support (o2SC).This multicenter, placebo-controlled randomized clinical trial was conducted in 19 intensive units (ICUs) France from April 2020 January 2021. Eligible were consecutive...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
<h3>Importance</h3> Persistent physical and mental disorders are frequent in survivors of COVID-19–related acute respiratory distress syndrome (ARDS). However, data on these among family members scarce. <h3>Objective</h3> To determine the association between patient hospitalization for COVID-19 ARDS vs from other causes risk posttraumatic stress disorder (PTSD)–related symptoms members. <h3>Design, Setting, Participants</h3> Prospective cohort study 23 intensive care units (ICUs) France...
Ceftaroline, the active form of prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated community-acquired pneumonia (CAP), including Streptococcus pneumoniae and common Gram-negative pathogens. FOCUS 1 randomized, double-blinded, Phase III study that was conducted to evaluate efficacy safety fosamil in treating patients CAP. The primary objective determine non-inferiority [lower limit 95% confidence interval (CI) ≥ −10%]...