A5029557518- CAR-T cell therapy research
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Intensive Care Unit Cognitive Disorders
- Electrospun Nanofibers in Biomedical Applications
- Biomedical Ethics and Regulation
- Biosimilars and Bioanalytical Methods
- Virus-based gene therapy research
- Bone Tissue Engineering Materials
- Respiratory Support and Mechanisms
- Safe Handling of Antineoplastic Drugs
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Lymphoma Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Viral Infectious Diseases and Gene Expression in Insects
- Pluripotent Stem Cells Research
- Muscle Physiology and Disorders
- Integrated Circuits and Semiconductor Failure Analysis
- Congenital Diaphragmatic Hernia Studies
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- HIV, Drug Use, Sexual Risk
Hôpital Saint-Louis
2020-2025
Université Paris Cité
2015-2024
Assistance Publique – Hôpitaux de Paris
2020-2024
Inserm
2017-2024
Sorbonne Paris Cité
2020-2023
Laboratoire d’immunologie intégrative du cancer
2022
Institut Mondor de Recherche Biomédicale
2017-2021
Université Paris-Est Créteil
2017-2020
Délégation Paris 5
2015-2020
Établissement Français du Sang
2017-2018
Abstract Sepsis, or systemic inflammatory response syndrome, is the major cause of critical illness resulting in admission to intensive care units. Sepsis caused by severe infection and associated with mortality 60% cases. Morbidity due sepsis complicated neuromyopathy, patients face long-term disability muscle weakness, energetic dysfunction, proteolysis wasting. These processes are triggered pro-inflammatory cytokines metabolic imbalances aggravated malnutrition drugs. Skeletal...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
Abstract Chimeric Antigen Receptor T cells (CAR-T) are an outbreaking treatment option for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) the most common specific toxicities, while severe neutropenia infections often observed as well. From March 2020, early G-CSF prophylaxis at day (D) two post-infusion was systematically proposed. We then compared patients treated before that date who...
Abstract Chimeric antigen receptor (CAR) T-cell therapies have shown significant benefits in the treatment of hematologic malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. Despite therapeutic advances offered by these innovative treatments, failures are still observed 15% to 40% patients with B-ALL >50% Several hypotheses emerged including CD19-negative or -positive relapses, low CAR activation and/or expansion vivo, exhaustion. To date, European Union, T...
In order to induce an efficient bone formation with human marrow mesenchymal stromal cells (hBMSC) associated a scaffold, it is crucial determine the key points of hBMSC action after in vivo transplantation as well appropriate features scaffold. To this aim we compared behavior when grafted onto two biomaterials allowing different potential vivo. The cancellous devitalized Tutoplast®-processed (TPB) and synthetic hydroxyapatite/β-tricalcium-phosphate (HA/βTCP) which give at 6weeks 100% 50%...
Abstract The possibility of using adipose tissue-derived stromal cells (ATSC) as alternatives to bone marrow-derived (BMSC) for repair has garnered interest due the accessibility, high cell yield, and rapid in vitro expansion ATSC. For clinical relevance, their forming potential comparison BMSC must be proven. Distinct differences between ATSC have been observed osteogenic vivo is not clear date. aim current study was compare osteogenesis human xenofree-expanded an ectopic nude mouse model...
The aim of this study was to evaluate the prognostic impact F-fluorodeoxyglucose positron emission tomography response at 1 month (M1) and 3 months (M3) after anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in a multicenter cohort 160 patients with relapsed/refractory large B-cell lymphomas (R/R LBCL). In total, 119 (75%) reached M1 evaluation; 64 (53%, 64/119) had complete (CR); 91% were Deauville Score (DS) 1-3. Progressionfree survival (PFS) overall (OS) significantly worse DS-5...
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<title>Abstract</title> Background Umbilical Cord-derived Mesenchymal Stromal Cells (UC-MSCs) display high immunoregulatory properties, offering new perspectives to treat severe immune and inflammatory diseases. However, the heterogeneity of their biological properties remains a challenge predict clinical response. The aim our study is evaluate strategy based on constitution pool several pre-selected donors reduce variability UC-MSCs improve immunomodulatory properties. Methods cords were...
Abstract Background Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) revealed their key role in immune regulation, offering promising therapeutic perspectives for and inflammatory diseases. We aimed to develop a production process of an UC-MSC-based product then characterize UC-MSC properties immunomodulatory activities vitro, related clinical use finally, transfer this technology good manufacturing practice (GMP) compliant facility, manufacture advanced therapy medicinal (ATMP)....
Abstract Background Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity the context clinical trials. This study presents method’s validation, assessing MSC’s ability to inhibit lymphocyte proliferation, according ICH Q2 standard. Methods MSC were co-cultured with CellTrace™ Violet-labeled Peripheral blood mononuclear (PBMC) coming from bank ten donors, at seven different ratios for 7...
Abstract Background The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify significant efficacy of umbilical cord-derived mesenchymal stromal cells in patients with SARS-CoV-2-induced acute respiratory distress syndrome. Safety on day 28 found to be good. aim our extended assess the 6- and 12-month safety UC-MSCs administration cohort. Methods A detailed multi-domain assessment conducted at 6 12 months...
Objectif : La prophylaxie préexposition « PrEP » est un outil de prévention contre le VIH pour les populations à haut risque disponible depuis 2016 en France. De primoprescription CeGIDD ou hospitalière, renouvellement la peut être assuré médecine générale. L’analyse des freins cette prescription et son suivi générale indispensable afin d’atteindre objectifs nécessaires observer l’infléchissement nouvelles contaminations. Méthodes Il s’agit d’une étude descriptive menée auprès d’un...