A5069565206- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Cerebrospinal fluid and hydrocephalus
- Blood groups and transfusion
- Teratomas and Epidermoid Cysts
- Pregnancy and preeclampsia studies
- Craniofacial Disorders and Treatments
- Parvovirus B19 Infection Studies
- Maternal and fetal healthcare
- Cleft Lip and Palate Research
- Family and Disability Support Research
- Hernia repair and management
- Neonatal Respiratory Health Research
- Genomic variations and chromosomal abnormalities
- Hemoglobinopathies and Related Disorders
- Urological Disorders and Treatments
- Neonatal and fetal brain pathology
- Mycobacterium research and diagnosis
- Head and Neck Surgical Oncology
- Pediatric Urology and Nephrology Studies
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2014-2025
Inserm
2017-2025
Université Paris Cité
2023-2025
Hôpital Armand-Trousseau
2015-2024
Hôpital Saint-Louis
2020-2024
Sorbonne Paris Cité
2018-2023
Hôpital d'Enfants
2019
Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé
2017
Maternité Port Royal
2014-2017
In Brief OBJECTIVE: Neonatal asphyxia may have severe consequences in term newborns. Our purpose was to identify possible risk factors of acidosis during pregnancy and labor. METHODS: a case–control study from January 2003 December 2008 three university perinatal centers (two French one Canadian hospitals), we analyzed 226 women with pregnancies complicated by neonatal (umbilical artery pH less than 7.00). Cases were individually matched controls normal acid-base status (pH 7.15 or greater)...
Anne-Gaël Cordiera, Mieke M. Canniebc, Lucie Guilbauda, Jocelyne De Laveaucoupetd, Jéléna Martinovice, Dorota Nowakowskaf, Malgorzata Milejska-Lewandowskag, Carlota Rodóh, Benjamin Viaris de Lesegnoi, Carmela Votinoj, Marie-Victoire Senatk, Jacques C. Janij* & Alexandra Benachiaa Department of Obstetrics, Gynecology and Reproductive Medicine, Centre Maladies Rares, Hernie Coupole Diaphragmatique, Hôpital Antoine Béclère, APHP, Université Paris Sud, Paris, France, b Radiology, University...
( BJOG . 2024;131(6):759–767. https://doi.org/10.1111/1471-0528.17624) Myelomeningocele (MMC), also referred to as open spina bifida, is the most severe type of bifida and a significant abnormality in neural tube. It consists sac filled with fluid found on back infants linked dysfunction lower limbs, digestion, urinary systems, well possible cognitive impacts. Research conducted by MOMS revealed advantages prenatal repair for MMC compared surgery after birth, resulting widespread acceptance...
ABSTRACT Objective To describe outcomes at 36 months of age in children with prenatally diagnosed Limited Dorsal Myeloschisis (LDM) and compared to Myelomeningocele (MMC). Method This was a retrospective study all successive patients postnatal confirmation prenatal diagnosis isolated LDM who were referred French National Reference center from 2014 2023 MMC cases. Postnatal evaluation both dysraphisms comprised standardized multidisciplinary evaluations. Results Of the 245 fetuses suspected...
ABSTRACT Objective To establish the prevalence of COL4A1 and COL4A2 gene mutations in fetuses presenting with a phenotype suggestive cerebral injury. Methods This was single‐center retrospective analysis all cases fetal anomalies or mutation over period 2009–2018. Inclusion criteria were: (1) severe and/or multifocal hemorrhagic lesions; (2) ischemic‐hemorrhagic lesions. These could be different ages associated schizencephaly porencephaly. Between those without mutation, we compared...
Recent studies have evaluated prenatal exome sequencing (pES) for abnormalities of the corpus callosum (CC). The objective this study was to compare imaging phenotype and genotype findings.This multicenter retrospective included fetuses with CC between 2018 2020 by ultrasound and/or MRI which pES performed. Abnormalities were classified as complete (cACC) or partial (pACC) agenesis CC, short (sCC), callosal dysgenesis (CD), interhemispheric cyst (IHC), pericallosal lipoma (PL), isolated not....
Objective To investigate cerebral anomalies other than Chiari type 2 malformation in fetuses with myelomeningocele (MMC). Design A retrospective cohort study a single tertiary centre. Setting review of associated cases prenatal diagnosis myelomeningocele. Population Seventy fetal Methods Ultrasound and MRI images were blindly reviewed. Postnatal imaging results the postmortem also The association between following ultrasound findings was measured: level defect, ventriculomegaly, microcephaly...
Folic acid supplementation is recommended for neural tube defect prevention during pregnancy. We conducted an observational, retrospective national registry study to determine the rate of dispensing periconceptional folic after prescription in a sample French women representative general population. Our population (n = 186,061) was population, recorded Health Data System database on pharmacy medication and mandatory reporting Between 2006 2016, 14.3% pregnant had month preceding conception...
Objective Show a prognostic value of brain changes in fetuses with intra uterine growth restriction (IUGR) on early neonatal outcome. Study Design We prospectively recruited pregnant women whose presented fetal weight < 5th centile. A MRI was performed between 28 and 32 weeks gestation (WG). Several biometrics were measured (as fronto-occipital diameter (FOD) transverse cerebellar (TCD)). Neonatal prognosis evaluated according to composite criterion. Results Of the 78 patients included, 62...
Atypical fetal chromosomal anomalies are more frequent than previously recognized and can affect development. We propose a screening strategy for genome-wide non-invasive prenatal test (NIPT) to detect these atypical (ACAs). Two sample cohorts were tested. Assay performances determined using Cohort A, which consisted of 192 biobanked plasma samples-42 with ACAs, 150 without. The rate additional invasive diagnostic procedures was B, 3097 pregnant women referred routine NIPT. Of the samples in...
Early pregnancy ultrasound scans are usually performed by nonexpert examiners in obstetrics/gynecology (OB/GYN) emergency departments. Establishing the precise diagnosis of location is key for appropriate management early pregnancies, and experts able to locate a first scan. A decision-support system based on semantic, expert-validated knowledge base may improve diagnostic performance transvaginal ultrasound.This study aims evaluate novel Intelligent Scan Assistant System diagnose determine...
Abstract Objective To investigate the effects of an adjuvant allogenic umbilical cord mesenchymal stromal cell (UC‐MSC) patch applied during fetal surgery on motor and sphincter function in ovine MMC model. Design defects were surgically created at 75 days gestation repaired 14 later. Population Ovine model: lambs. Methods We compared lambs that received a UC‐MSC with control group acellular patch. Main Outcome Measures Clinical neurological assessment was performed 2 24 hours life included...