Élise Morawiec
A5068940404- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Cardiac Arrest and Resuscitation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Family and Patient Care in Intensive Care Units
- Glioma Diagnosis and Treatment
- Trauma Management and Diagnosis
- Nosocomial Infections in ICU
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atrial Fibrillation Management and Outcomes
- Pneumonia and Respiratory Infections
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Sarcoidosis and Beryllium Toxicity Research
- Ultrasound in Clinical Applications
- CNS Lymphoma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Antifungal resistance and susceptibility
Sorbonne Université
2015-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Pitié-Salpêtrière Hospital
2016-2022
Hôpital Charles-Foix
2015-2022
Sorbonne Paris Cité
2020-2022
Hôpital Saint-Antoine
2021
Saint Louis University Hospital
2021
Hôpital Lariboisière
2021
Hôpital Rothschild
2021
Collaborative Group (United States)
2020
Although patients with SARS-CoV-2 infection have several risk factors for ventilator-associated lower respiratory tract infections (VA-LRTI), the reported incidence of hospital-acquired is low. We aimed to determine relationship between pneumonia, as compared influenza pneumonia or no viral infection, and VA-LRTI.Multicenter retrospective European cohort performed in 36 ICUs. All adult receiving invasive mechanical ventilation > 48 h were eligible if they had: at ICU admission. VA-LRTI,...
There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals particularly exposed to SARS-CoV-2 infection and at potential risk reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) (M3) after the onset symptoms. All had anti-receptor binding domain (RBD) IgA D21, decreasing 38.5% M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21...
Background This study provides a detailed imaging assessment in large series of patients infected with coronavirus disease 2019 (COVID-19) and presenting neurologic manifestations. Purpose To review the MRI findings associated acute manifestations COVID-19. Materials Methods was cross-sectional conducted between March 23 May 7, 2020, at Pitié-Salpêtrière Hospital, reference center for COVID-19 Paris area. Adult were included if they had diagnosis severe respiratory syndrome 2 (SARS-CoV-2)...
Abstract Importance: As the pandemic of COVID-19 is still under progression, identification prognostic factors remains a global challenge. The role smoking has been suggested among disease risk factors, although it highly controversial. Objective: To evaluate whether rate daily smokers in patients with was different to that French population. Participants: COVID-19-infected in- and outpatients large university hospital between February 28, 2020 March 30, for from 23, till April 9,...
Intensive care unit (ICU)-acquired weakness and diaphragm dysfunction are frequent conditions, both associated with poor prognosis in critically ill patients. While it is well established that ICU-acquired severely impairs long-term prognosis, the association of this outcome has never been reported. This study investigated whether negative outcomes coexistence a particular 2-year survival health-related quality life (HRQOL).This an ancillary derived from observational cohort study. Patients...
Diaphragm dysfunction is defined by a value of twitch tracheal pressure in response to magnetic phrenic stimulation (twitch pressure) amounting less than 11 cmH2O. This study assessed whether this threshold or lower one would predict accurately weaning failure from mechanical ventilation. Twitch was compared ultrasound measurement diaphragm function.In patients undergoing first spontaneous breathing trial, function evaluated and (thickening fraction). Receiver operating characteristics...
Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large study has compared the incidence of IPA between and influenza patients.To determine putative in critically ill SARS-CoV-2 patients, with patients.This was planned ancillary analysis coVAPid retrospective European cohort. Consecutive adult patients requiring mechanical ventilation > 48 h pneumonia or were included. The 28-day cumulative IPA, based on Blot definition,...
<h3>Introduction</h3> Non-invasive ventilation (NIV) is part of standard care in amyotrophic lateral sclerosis (ALS). Intolerance or unavailability NIV, as well the quality correction nocturnal hypoventilation, has a direct impact on prognosis. <h3>Objectives</h3> We describe importance NIV failure due to upper airway obstructive events, clinical characteristics, their prognosis ALS. <h3>Methods</h3> Retrospective analysis data 190 patients with ALS and single centre for period 2011–2014....
Importance: As the pandemic of COVID-19 is still under progression, identification prognostic factors remains a global challenge. The role cigarette smoking has been suggested among disease’s epidemiological risk factors, although it highly controversial. Objective: To evaluate correlation daily with susceptibility to develop SARS-CoV-2 infection. Participants: We estimated rates current smokers in COVID-19-infected patients large French university hospital between February 28th , 2020 and...
Abstract Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak is spreading worldwide. To date, no specific treatment has convincingly demonstrated its efficacy. Hydroxychloroquine and lopinavir/ritonavir have potential interest, but virological clinical data are scarce, especially in critically ill patients. Methods present report took the opportunity of compassionate use successive drug shortages to compare effects two therapeutic options, hydroxychloroquine,...
<h3>Importance</h3> There is evidence of central nervous system impairments associated with coronavirus disease 2019 (COVID-19) infection, including encephalopathy. Multimodal monitoring patients COVID-19 may delineate the specific features COVID-19–related encephalopathy and guide clinical management. <h3>Objectives</h3> To investigate clinical, biological, brain magnetic resonance imaging (MRI) findings in association electroencephalographic (EEG) for COVID-19, to better refine <h3>Design,...
To describe health-related quality of life (HRQoL) and dyspnea COVID-19, 2 12 months after an intensive care unit (ICU) stay.Patients discharged from the ICU between April June 2020 subsequently transferred to inpatient rehabilitation facility were assessed admission. HRQoL was by EuroQoL EQ-5D-3L (visual analog scale time trade-off normalized French population algorithm) modified Medical Research Council (mMRC) scale.We enrolled 94 patients. Median 0.80 (interquartile range, 0.36-0.91) at...
Background: Identification of prognostic factors in COVID-19 remains a global challenge. The role smoking is still controversial. Methods: PCR-positive in- and outpatients with symptomatic from large French University hospital were systematically interviewed for their status, use e-cigarette, nicotinic substitutes. rates daily smokers compared using the same habit questionnaire to those 2019 general population, after standardisation sex age. Results: inpatient group was composed 340...
Importance: As the pandemic of COVID-19 is still under progression, identification prognostic factors remains a global challenge. The role cigarette smoking has been suggested among disease’s epidemiological risk factors, although it highly controversial. Objective: To evaluate correlation daily with susceptibility to develop SARS-CoV-2 infection. Participants: We estimated rates current smokers in COVID-19-infected patients large French university hospital between February 28th , 2020 and...
Abstract Background Identification of prognostic factors in COVID-19 remains a global challenge. The role smoking is still controversial. Objective To evaluate the rate daily smokers patients with COVID-19. Methods in-and outpatients from large French university hospital were systematically interviewed for their status, use e-cigarette and nicotinic substitutes. rates compared to those 2019 general population, after standardization sex age. Results inpatient group was composed 340 patients,...
Abstract Background Ventilator-associated pneumonia (VAP) is common in patients with severe SARS-CoV-2 pneumonia. The aim of this ancillary analysis the coVAPid multicenter observational retrospective study to assess relationship between adjuvant corticosteroid use and incidence VAP. Methods Planned a European cohort 36 ICUs. Adult receiving invasive mechanical ventilation for more than 48 h were consecutively included February May 2020. VAP diagnosis required strict definition clinical,...
Abstract Background Diaphragm dysfunction and weaning-induced pulmonary oedema are commonly involved during weaning failure, but their physiological interactions have been poorly reported. Our hypothesis was that diaphragm is not particularly associated with oedema. Methods It a single-centre study conducted in patients who had failed first spontaneous breathing trial underwent second trial. The function evaluated by measuring the tracheal pressure generated response to bilateral magnetic...
The present study was designed to investigate the evolution and impact of respiratory muscles function limb strength on weaning success in prolonged tracheotomized patients. primary objective determine whether change over time is or not associated with success. Tracheotomized patients who were ventilator dependent upon admission at a center eligible. Diaphragm assessed phrenic nerve stimulation technique ultrasound measure diaphragm thickening fraction (TFdi) excursion (EXdi). Global muscle...