A5101935769- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Healthcare Systems and Practices
- Mosquito-borne diseases and control
- Blood transfusion and management
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Hepatitis C virus research
- Iron Metabolism and Disorders
- Viral Infections and Vectors
- Syphilis Diagnosis and Treatment
- Diabetes and associated disorders
- Health, Medicine and Society
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- Malaria Research and Control
- Hepatitis Viruses Studies and Epidemiology
- Platelet Disorders and Treatments
- SARS-CoV-2 detection and testing
- Sex work and related issues
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Liver Disease and Transplantation
Établissement Français du Sang
2009-2024
International Human Frontier Science Program Organization
2021-2023
Sorbonne Université
2013-2022
Assistance Publique – Hôpitaux de Paris
2010-2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2022
Pitié-Salpêtrière Hospital
2022
Aix-Marseille Université
2022
Centre de Génétique Moléculaire
2021
Centre Hospitalier Universitaire de Martinique
2009-2018
Centre Hospitalier Universitaire de Nîmes
1991-2014
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
Background During Dec-2013, a chikungunya virus (CHIKV) outbreak was first detected in the French-West Indies. Subsequently, dispersed to other Caribbean islands, continental America and many islands Pacific Ocean. Previous estimates of attack rate were based on declaration clinically suspected cases. Methods/Principal findings Individual testing for CHIKV RNA all (n = 16,386) blood donations between Feb-24th 2014 Jan-31st 2015 identified 0·36% 0·42% positives Guadeloupe Martinique,...
The French health authorities are considering expanding the current selective hepatitis E virus (HEV)-RNA testing procedure to include all donations in order further reduce transfusion-transmitted HEV infection. Data obtained from blood donors (BDs) tested for HEV-RNA between 2015 and 2021 were used assess most efficient nucleic acid (NAT) strategy.Viral loads (VLs) plasma volume of components, as well an dose 3.85 log IU infectious threshold assay with a 95% limit detection (LOD) at 17...
Pathogen reduction (PR) technology may reduce the risk of transfusion-transmitted infections (TTIs), notably bacterial infection (TTBI) associated with platelet concentrates (PCs). PR (amotosalen/UVA treatment) was implemented for all PCs transfused in France November 2017. No detection place beforehand. The study aimed to assess impact PC on TTI and TTBI near-miss occurrences.
The practice of platelet (PLT) transfusions has been adopted into the standard clinical in many dengue-endemic countries. Because patients were found to have received unnecessary PLT transfusions, development guidelines for management dengue with thrombocytopenia become a necessity.An emergency department-based prospective observational study was conducted Martinique during outbreak adult presenting an acute febrile illness. Patients severe bleeding and/or who underwent invasive intensive...
Summary To lower the alloimmunization risk following transfusion in blacks, we developed two genotyping assays for large‐scale screening of Comorian and Afro‐Caribbean donors. One was a multiplex SNaPshot assay designed to identify ce s (340), ceMO/AR/EK/BI/SM, , (1006) KEL*6/*7 alleles. The other fragment detect RHD, RHDψ RHCE*C 455A>C transversion consistent with (C)ce Type 1 DIII Type5 . Variant RHCE*ce alleles or RH haplotypes were detected 58·69% Comorians 41·23% Afro‐Caribbeans....
Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350 386) 96.2% (382 397) Guadeloupe. Only 30% these adults recalled having had disease before. Serotype-specific neutralization assays applied to a subset IgG-positive indicated that majority (77 96;...
Zika virus is an Aedes-borne Flavivirus causing fever, arthralgia, myalgia rash, associated with Guillain-Barré syndrome and suspected to induce microcephaly in the fetus. We report here complete coding sequence of first characterized Caribbean strain, isolated from a patient Martinique December, 2015.
Human T-lymphotropic virus type 1 (HTLV-1) has been discovered in 1980 and linked to tropical spastic paraparesis (HAM/TSP) 1985 Martinique. There is no data on HAM/TSP incidence trends. We report, the present work, temporal trends of Martinique over 25 years.Martinique a Caribbean French West Indies island deserved by unique Neurology Department involved diagnosis management. A registry set up since 1986 patients diagnosed for were prospectively registered. Only with definite onset between...
Hepatitis B virus (HBV) infection is the most frequent viral found in blood donors (BDs) France. We analyzed epidemiological and sero-molecular data on HBV gathered over past two decades by French haemovigilance surveillance network, screening laboratories, national reference center for transfusion infectious risks (NRC). Between 2000 2020, 6149 of 58,160,984 donations (1.06/10,000) tested positive, 98% them from first-time (FTBDs). In addition, 2212 (0.0071%) 30,977,753 screened DNA which...
Since the advent of AIDS, men who have sex with (MSM) often been deferred from blood donation. In France, quarantine plasma donation by MSM donors same deferral rules as for other was introduced in July 2016 and continued up to March 2022. At this time, MSM-specific criteria were lifted all or The donor deferral, well rate infectious markers would otherwise activity, evaluated compared those during time period June 2022.A total 8843 made 12,250 applications. overall very high (75.2%), mainly...
BackgroundSyphilis in blood donors (BD) has increased many countries.AimWe aimed to describe trends syphilis seroposivity BD France, identify risk factors and assess if a non-treponemic test (NTT) could define having recovered from for more than 1 year.MethodsThe analysis covered the period 2007 2022 45,875,939 donations. Of 474 syphilis-positive 2022, 429 underwent additional investigations with an NTT. History of was obtained at post-donation interview or based on serology results repeat...
With the implementation of universal leucoreduction blood components in several industrialised countries, problems associated with leucocyte filtration sickle cell trait have been reconsidered. In this study, we assessed use high performance filters for packed red cells donated from subjects and evaluated incidence recurrence altered filterability.Twenty-one volunteer donors HbAS were compared to 21 HbAA selected at random. The main parameters analysed residual white count post-filtration...
Implementing a ferritin testing policy for whole blood (WB) donors may prevent iron deficiency (ID, <26 ng/mL) and anaemia, but induce donation losses. As part of national prevention plan in France, we aimed to estimate its impact on ID, anaemias WB donations among at high risk ID.A micro-simulation model was developed evaluate different scenarios compared the current situation without as reference scenario. The following were simulated: minimum scenario with 6-month deferral absent store...
Highlights•Immunity in France before the vaccination campaign was too low to achieve herd immunity•The infection/hospitalization ratio increased with age•4 months after seroconversion, modeling estimated antibody decay be ∼50%•IgG seroprevalence lower individuals O blood type than A, B, and ABSummaryWe conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence French donors (n = 32605), from March-2020 January-2021. A mathematical model combined daily number of hospital...
Summary Prevention of ABO‐incompatible red cell transfusions (ABO‐it) requires accurate donor and patient identification correct application processes for transfusion safety. In France Germany, a bedside identity check ABO compatibility test are performed. the UK, an check, often structured as checklist, is performed with or without electronic (ePID). To compare efficacy ABO‐it preventive measures, frequencies causes between 2013 2022 were investigated in all three countries. Despite...
Retrospective interpretation of sequenced data in light the current literature is a major concern field. Such reinterpretation manual and both human resources variable operating procedures are main bottlenecks.Genome Alert! method automatically reports changes with potential clinical significance variant classification between releases ClinVar database. Using submissions across time, this assigns validity category to gene-disease associations.Between July 2017 December 2019, retrospective...