A5004200189- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Acne and Rosacea Treatments and Effects
- Sex work and related issues
- Escherichia coli research studies
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- HIV, TB, and STIs Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
- Linguistic Variation and Morphology
- Dermatology and Skin Diseases
- Cytomegalovirus and herpesvirus research
- Female Genital Mutilation/Cutting Issues
- Syntax, Semantics, Linguistic Variation
- Photodynamic Therapy Research Studies
- Language, Discourse, Communication Strategies
- Parvovirus B19 Infection Studies
- Infant Nutrition and Health
- Immune Response and Inflammation
- melanin and skin pigmentation
- Urological Disorders and Treatments
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
Inserm
2015-2024
Université Paris Cité
2015-2024
Hôpital Cochin
2011-2024
Assistance Publique – Hôpitaux de Paris
2011-2024
Institut Cochin
2015-2024
Centre National de la Recherche Scientifique
2020-2023
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2005-2022
Johnson & Johnson (Germany)
2022
Johnson & Johnson (United States)
2022
Délégation Paris 5
2010-2021
Significance The origins of the Malagasy raise questions about ancient connections between continents; moreover, because ancestors are fundamental to society, is also a heated topic around country, with numerous proposed hypotheses. This study provides comprehensive view genomic diversity (including maternal lineages, paternal and genome-wide data) based on sampling 257 villages across Madagascar. observed spatial patterns lead scenario recent sex-biased admixture Bantu Austronesian island....
ABSTRACT Syphilis diagnosis is based on clinical observation, serological analysis, and dark-field microscopy (DFM) detection of Treponema pallidum subsp. , the etiological agent syphilis, in skin ulcers. We performed a nested PCR (nPCR) assay specifically amplifying tpp47 gene T. from swab blood specimens. studied cohort 294 patients with suspected syphilis 35 healthy volunteers. Eighty-seven had primary 103 secondary 40 latent 64 were found not to have syphilis. The nPCR results for...
The Bajo, the world's largest remaining sea nomad group, are scattered across hundreds of recently settled communities in Island Southeast Asia, along coasts Indonesia, Malaysia and Philippines. With a significant role historical trading, Bajo lived until as nomads, spending their entire lives on houseboats while moving long distances to fish trade. Along routes they traveled, intermarried with local land-based groups, leading 'maritime creolization', process whereby retained culture, but...
Acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. Propionibacterium acnes (P. acnes), gram-positive anareobic bacterium, plays critical role in development these lesions. This study aimed at determining whether reactive oxygen species (ROS) are produced by keratinocytes upon P. infection, dissecting mechanism this production, and investigating how phenomenon integrates general response induced acnes. In our hands, ROS, especially superoxide anions (O2(*-)), were...
Abstract Objective Systemic sclerosis (SSc) is characterized by the fibrosis of various organs, vascular hyperreactivity, and immunologic dysregulation. Since Notch signaling known to affect fibroblast homeostasis, angiogenesis, lymphocyte development, we undertook this study investigate role pathway in human murine SSc. Methods SSc was induced BALB/c mice subcutaneous injections HOCl every day for 6 weeks. activation analyzed tissues from with patients scleroderma. Mice were either treated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRaman spectra of cobalt molybdenum oxide supported on silicaH. Jeziorowski, H. Knoezinger, P. Grange, and GajardoCite this: J. Phys. Chem. 1980, 84, 14, 1825–1829Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/j100451a017https://doi.org/10.1021/j100451a017research-articleACS PublicationsRequest reuse permissionsArticle Views733Altmetric-Citations79LEARN...
To investigate whether the glycosylation and sialylation levels of anti-proteinase 3 (anti-PR3) antibodies could affect their pathogenicity, these be correlated with activity granulomatosis polyangiitis (Wegener's) (GPA).Forty-two serum samples positive for anti-PR3 from 42 patients active or weakly active/inactive GPA were included. Anti-PR3 assayed by enzyme-linked immunosorbent assay, assessed lectin assay. The IgG purified healthy donors active, remitted, disease permethylation mass...
Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacteria encountered in inflammatory acne lesions, particularly the pilosebaceous follicle. P. triggers a strong immune response involving keratinocytes, sebocytes and monocytes, target cells during development. Lipoteicoic acid peptidoglycan induce reaction, but no surface protein interacting with Toll-like receptors has been identified. proteins have extracted by lithium stripping shown to CXCL8 production...
<i>Background:</i> Anti-tumor necrosis factor (TNF) agents are increasingly being used for a rapidly expanding number of rheumatic and systemic diseases. As result this use, the longer follow-up periods treatment, there growing reports development autoimmune processes related to anti-TNF agents. The use has been associated with more cases diseases, principally cutaneous vasculitis, lupus-like syndrome, lupus erythematosus interstitial lung disease....
Two major Treponema pallidum subtypes, 14 d/g and d/f, were identified in a population of 119 patients with syphilis Paris, France, characterized by high proportion men who have sex men. A new subtype named 11 q/j was characterized, reinfection case determined 1 patient having consecuitve infection at 19-month interval.
Syphilis, caused by Treponema pallidum subsp. (TPA), remains an important public health problem with increasing worldwide prevalence. Despite recent advances in vitro cultivation, genetic variability of this pathogen during infection is poorly understood. Here, we present contemporary and geographically diverse complete treponemal genome sequences isolated directly from patients using a methyl-directed enrichment prior to sequencing. This approach reveals that approximately 50% the diversity...
Abstract Although acne is the most common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood. Here we show that GATA6, which expressed in upper pilosebaceous unit of normal skin, down-regulated acne. GATA6 controls keratinocyte proliferation and differentiation to prevent hyperkeratinisation infundibulum, primary pathological event When overexpressed immortalised sebocytes, triggers a junctional zone sebaceous program whilst limiting lipid production...
Most people in Irish society, when asked, &#8220;Do we experience earthquakes Ireland?&#8221; would likely answer, &#8220;No don&#8217;t&#8221;. However, this is incorrect &#8211; do occur Ireland and are occasionally felt. This misconception understandable as not located near the edge of a plate boundary tend to be very low magnitude (M2.5 largest onshore earthquake recorded so far). As result, regular thought for population Ireland. We aim raise awareness on...
Background Treponema pallidum subsp. endemicum (TEN) is the causative agent of endemic syphilis (bejel). An unusual human TEN 11q/j isolate was obtained from a syphilis-like primary genital lesion patient that returned to France Pakistan. Methodology/Principal findings The characterized using nested PCR followed by Sanger sequencing and/or direct Illumina sequencing. Altogether, 44 chromosomal regions were analyzed. Overall, clustered with strains Bosnia A and Iraq B as expected previous...
Treponema pallidum subsp. pallidum, the causative agent of sexually transmitted syphilis, detected in clinical samples from France, was subjected to molecular typing using recently developed Multilocus Sequence Typing system. The (n = 133) used this study were collected 2010-2016 patients with diagnosed primary or secondary syphilis attending outpatient centers hospitals several locations France. Altogether, 18 different allelic profiles found among fully typed 112). There five variants...
Abstract Background. Syphilis remains a significant public health problem. We conducted prospective study to define more precisely the clinical and biological characteristics of patients with neurosyphilis (NS), we assessed diagnostic value nested polymerase chain reaction (PCR) testing for Treponema pallidum in cerebrospinal fluid (CSF) samples. Methods. From 2001 2013, included 40 (90% men; 45% infected human immunodeficiency virus) NS, defined as syphilis neurological and/or...
ABSTRACT Three antigenic variants of the K88 fimbrial adhesin exist in nature, K88ab, K88ac, and K88ad. Enterotoxigenic Escherichia coli (ETEC) strains that produce these fimbriae cause life-threatening diarrhea some but not all young pigs. The susceptibility pigs to organisms has been correlated with adherence bacteria isolated enterocyte brush borders. Whether correlation holds for multiple over a broad genetic base is unknown was impetus this study. We also desired examine expression...
Putative receptors of Escherichia coli K88 fimbriae are either tightly membrane bound or an integral part membranes. Thus, proteins associated with piglet small intestinal mucosae were solubilized by a detergent (deoxycholate). A 74-kDa glycoprotein (GP74) purified from enterocyte and brush border preparations was specifically detected in vitro K88ab fimbriae. GP74 recognized only the phenotypically adhesive animals. Metaperiodate treatment abolished recognition, indicating that...
There is a lack of large studies appraising the effect human immunodeficiency virus (HIV) on course syphilis since advent highly active antiretroviral therapy (HAART). We aimed to appraise HIV clinical and serologic features at baseline during follow-up in post-HAART era. designed retrospective cohort study consecutive cases, diagnosed between 2000 2007, an academic venereal disease center. Data were collected using standardized medical forms. Patients treated according European guidelines....
Recently, the World Health Organization launched a campaign to eradicate tropical disease yaws, caused by bacterium Treponema pallidum subsp. pertenue; however, for decades researchers have questioned whether flies act as vector pathogen that could facilitate transmission.A total of 207 fly specimens were trapped in areas Africa which T. pallidum-induced skin ulcerations are common wild baboons; 88 from Tarangire National Park and 119 Lake Manyara Tanzania analyzed PCR presence DNA.We report...
ABSTRACT Diarrheal disease caused by enterotoxigenic Escherichia coli expressing the K88 (F4) fimbrial adhesin (K88 ETEC) is a significant source of mortality and morbidity among newborn weaned piglets. adhesins are filamentous surface appendages whose lectin (carbohydrate-binding) activity allows ETEC to attach specific glycoconjugates (receptors) on porcine intestinal epithelial cells. There three variants (K88ab, K88ac, K88ad), which possess different, yet related, carbohydrate-binding...