A5101998171- Venous Thromboembolism Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Orthopedic Infections and Treatments
- Mycobacterium research and diagnosis
- Pericarditis and Cardiac Tamponade
- Infectious Diseases and Tuberculosis
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Cardiovascular Function and Risk Factors
- Cystic Fibrosis Research Advances
- Antimicrobial Resistance in Staphylococcus
- Tuberculosis Research and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Acne and Rosacea Treatments and Effects
- Liver Disease Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Hepatitis C virus research
Hôpital Cochin
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Université Paris Cité
2012-2024
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2009-2024
Institut Cochin
2009-2024
Inserm
2009-2024
Centre National de la Recherche Scientifique
2011-2024
Hôpital Broca
2016-2021
Délégation Paris 5
2010-2020
Centre Hospitalier Universitaire de Grenoble
2000-2018
Aims of this study were to: (i) evaluate whether the cluster membership could have an impact on hetero-resistance phenotype to colistin in Enterobacter cloacae complex (ECC); and (ii) determine genetic mechanism ECC.A collection 124 clinical isolates belonging 13 clusters used analyse (MICs determined using broth microdilution method, Etest population analysis profiling). Different mutants (ΔphoP, ΔphoQ, ΔphoPQ, ΔpmrA, ΔpmrB, ΔpmrAB, ΔarnE, ΔarnF ΔarnBCADTEF) constructed tested for their...
Propionibacterium acnes (P. acnes) is an anaerobic, Gram-positive bacteria encountered in inflammatory acne lesions, particularly the pilosebaceous follicle. P. triggers a strong immune response involving keratinocytes, sebocytes and monocytes, target cells during development. Lipoteicoic acid peptidoglycan induce reaction, but no surface protein interacting with Toll-like receptors has been identified. proteins have extracted by lithium stripping shown to CXCL8 production...
ObjectiveBetween July 1992 and December 1994, 16 French hospital centres, mainly cardiological, participated in a non-controlled observational study on venous thromboembolic disease. The objective of this survey was to collect data concerning the current status pulmonary embolism deep thrombosis.
Mupirocin is the cornerstone of decolonization regimens, a successful strategy to prevent healthcare-associated staphylococcal infections. Several recent studies have reported alarming results: (i) an extending reservoir mupA, ancestral mobile resistance gene, among coagulase-negative staphylococci (CoNS); (ii) emergence new gene (mupB); and (iii) growing number mupirocin-resistant methicillin-resistant Staphylococcus aureus (MRSA), including highly pathogenic clones. We performed nationwide...
In the context of increasing antimicrobial resistance in Enterobacterales, management these UTIs has become challenging. We retrospectively assess prevalence Enterobacterales isolates recovered from urinary tract samples France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided susceptibility 134,162 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae...
Bacteria belonging to the Enterobacter genus are frequently isolated from clinical samples but unusual causative agents of orthopedic implant infections. Twelve genetic clusters (clusters I XII) and one sequence crowd (sequence xiii) can be distinguished within cloacae nomenspecies on basis hsp60 analysis, until now, none these could specifically associated with a disease. In order investigate if specific would involved in infections material, two series bacterial isolates identified as E....
Abstract Background Cutibacterium species are common pathogens in periprosthetic joint infections (PJI). These often treated with β-lactams or clindamycin as monotherapy, combination rifampin. Clinical evidence supporting the value of adding rifampin for treatment PJI is lacking. Methods In this multicenter retrospective study, we evaluated patients and a minimal follow-up 12 months. The primary endpoint was clinical success, defined by absence infection relapse new infection. We used...
Tigecycline is a new broad-spectrum antibiotic. Nausea and vomiting are its most common side-effects. We describe here case of severe acute pancreatitis related to tigecycline in order highlight the possible occurrence this adverse event remind clinicians measure lipase rate if any doubt.
Pelvic bone and/or soft tissue sarcoma removal surgeries are associated with a high rate of surgical site infection (SSI). The recommended antibiotic prophylaxis (ABP) duration is 24-48 h. We aimed to assess the impact extended ABP (5 days) on SSI and describe microbiology in pelvic sarcomas.We retrospectively included all consecutive patients who underwent surgery between January 2010 June 2020.We analyzed 146 (45, 31%) or (101, 69%). Sixty (41%) developed SSI. occurred 13/28 (46.4%) group...
Ceftolozane-tazobactam was tested against 58 multidrug-resistant nonfermenting Gram-negative bacilli (35 Pseudomonas aeruginosa, 11 Achromobacter xylosoxydans, and 12 Stenotrophomonas maltophilia isolates) isolated from cystic fibrosis patients compared to ceftolozane alone, ceftazidime, meropenem, piperacillin-tazobactam. the most active agent P. aeruginosa but inactive A. xylosoxydans S. In time-kill experiments, ceftolozane-tazobactam had complete bactericidal activity 2/6 clinical isolates (33%).
This study aimed at characterizing the pharmacokinetics (PK) of oral levofloxacin in adult patients order to optimize dosing scheme and explore PK/pharmacodynamics (PD) bone joint infections (BJIs).From November 2015 December 2019, all hospitalized Cochin Hospital, treated with who had least one dosage for therapeutic drug monitoring were included. PK was described using non-linear mixed-effect modelling. In a subgroup BJIs, association between PK, MIC isolated pathogen clinical outcome...
We used capillary electrophoresis-single-strand conformation polymorphism (CE-SSCP) analysis of PCR-amplified 16S rRNA gene fragments for rapid identification Pseudomonas aeruginosa and other gram-negative nonfermenting bacilli isolated from patients with cystic fibrosis (CF). Target sequences were amplified by using forward reverse primers labeled various fluorescent dyes. The PCR products denatured heating separated gel electrophoresis an automated DNA sequencer. Data analyzed GeneScan 672...