A5089156352- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pediatric health and respiratory diseases
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Pleural and Pulmonary Diseases
- Heart Failure Treatment and Management
- Neuropeptides and Animal Physiology
- Antifungal resistance and susceptibility
- Lung Cancer Diagnosis and Treatment
- Congenital Ear and Nasal Anomalies
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lung Cancer Research Studies
- Vascular Anomalies and Treatments
Assistance Publique – Hôpitaux de Paris
2010-2021
Hôpital Cochin
2011-2021
Université Paris Cité
2011-2021
Inserm
1986-2021
Institut Cochin
2021
Délégation Paris 5
2010-2019
Sorbonne Paris Cité
2011-2019
South Texas Veterans Health Care System
2018
COPD Foundation
2015
Boston University
2015
Tiotropium delivered at a dose of 5 μg with the Respimat inhaler showed efficacy similar to that 18 tiotropium HandiHaler inhalation device in placebo-controlled trials involving patients chronic obstructive pulmonary disease (COPD). Although was associated reduced mortality, as compared placebo, more deaths were reported than placebo.In this randomized, double-blind, parallel-group trial 17,135 COPD, we evaluated safety and once-daily 2.5 or μg, μg. Primary end points risk death...
We examined the effects of acute exposure to cigarette smoke on airway responses substance P in anesthetized guinea pigs and activity neutral endopeptidase (NEP). After air or we measured change total pulmonary resistance (RL) induced by increasing concentrations aerosolized absence presence NEP inhibitor phosphoramidon. In phosphramidon bronchoconstrictor were greater smoke-exposed than air-exposed animals. Phosphoramidon did not further potentiate pigs, whereas it so phosphoramidon,...
Mucosa-associated lymphoid tissue-derived (MALT) lymphoma, a low grade B-cell extranodal is the most frequent subset of primary pulmonary lymphoma. Our objective was to evaluate initial extent disease and analyse characteristics long-term outcome these patients. All chest pathological departments teaching hospitals in Paris were contacted order identify patients with histological diagnosis lymphoma MALT subtype. 63 cases identified. The median age 60 yrs. 36% had no symptoms at diagnosis....
This randomised, double-blind, parallel-group, 1-yr study compared the effect of tiotropium 18 µg once daily (n = 500) and placebo 510) on exacerbations, associated health resource use (HRU) airflow limitation in chronic obstructive pulmonary disease (COPD) patients. The mean± sd number exacerbations during past year was 2.14±1.40, mean weekly morning peak expiratory flow (PEF) 259.6±96.1 L·min −1 forced volume one second (FEV 1 ) 1.37±0.45 L. Tiotropium significantly delayed time to first...
ABSTRACT Aspergillus fumigatus is the most frequent fungus found in sputum of cystic fibrosis (CF) subjects. Itraconazole prescribed for allergic bronchopulmonary aspergillosis (ABPA) or bronchitis CF We hypothesized that A. isolates subjects with previous exposure to itraconazole was associated higher prevalence azole resistance. From June 2010 April 2011, samples from adult at Cochin University Hospital (France) were examined systematically detection . MICs against azoles screened using...
We examined the effects of viral respiratory infection by Sendai virus on airway responsiveness to tachykinins in guinea pigs. measured change total pulmonary resistance induced substance P or capsaicin presence absence neutral endopeptidase inhibitor, phosphoramidon, infected and noninfected animals. In bronchoconstrictor responses were greater than Phosphoramidon did not further potentiate animals, whereas it so Studies performed vitro showed that nonadrenergic noncholinergic bronchial...
A total of 657 sputum samples from 201 cystic fibrosis adult patients were collected during a 24-month period (2005–2006). We retrospectively analyzed the fungal colonization respiratory tract these individuals by linking medical records and microbiological data. Filamentous fungi isolated specimens 65.6% patients, with Aspergillus fumigatus being predominant species recovered as it was found in 56.7% patients. observed no difference for gender, pancreatic status cirrhosis or without A....
In COPD patients, mortality risk is influenced by age, severity of respiratory disease, and comorbidities. With an unbiased statistical approach we sought to identify clusters patients examine their risk.Stable subjects (n = 527) were classified using hierarchical cluster analysis clinical, functional imaging data. The relevance this classification was validated prospective follow-up mortality.The most relevant patient that based on three (phenotypes). Phenotype 1 included at very low...
This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France November 2011. The purpose this was to evidence (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with disease were reviewed, including cellular obliterative bronchiolitis. Many conditions have been airway infections, connective tissue diseases inflammatory bowel...
Little knowledge exists on structural changes and plugging in small airways cystic fibrosis.To characterise the extent of contribution secreted mucins to plugs.Small patients with fibrosis at transplantation (n = 18) were compared control non-smokers 10). Tissue sections stained Alcian blue (AB)/periodic acid-Schiff (PAS), for MUC5B MUC5AC, neutrophils its chemoattractant interleukin (IL) 8. Epidermal growth factor receptor (EGFR) ligand pro-transforming alpha also identified using...
Substance P and related tachykinins contribute to the airway hyperresponsiveness caused by toluene diisocyanate (TDI) in guinea pigs. Neutral endopeptidase (NEP) is an important modulator of substance P-induced responses. To test hypothesis that exposure TDI would increase responsiveness inhibiting activity this enzyme, we determined dose required pulmonary resistance 200% above baseline (PD200) before after administration pharmacologic inhibitor phosphoramidon pigs studied 1 h a 1-h air or...
To determine whether neutral endopeptidase (NEP), also called enkephalinase (EC 3.4.24.11), modulates the effects of exogenous and endogenous tachykinins in vivo, we studied aerosolized phosphoramidon, a specific NEP inhibitor, on responses to substance P (SP) atropine-resistant response vagus nerve stimulation (10 V, 5 ms for 20 s) guinea pigs. SP alone (10(-7) 10(-4) M; each concentration, 7 breaths) caused no change total pulmonary resistance (RL, greater than 0.5). Phosphoramidon (10(-4)...
Rationale: Although in patients with diffuse bronchiectasis (DB) and a normal sweat test the presence of one mutation cystic fibrosis transmembrane conductance regulator (CFTR) gene is frequently observed, its pathogenic role development DB remains unclear.Objectives: To evaluate association between CFTR heterozygosity protein dysfunction airways DB.Methods: Nasal potential difference was measured 122 unknown origin (Cl− < 60 mmol/L). They were classified according to mutations: zero (85...
Wise, Robert A.; Anzueto, Antonio; Cotton, Daniel; Dahl, Ronald; Devins, Theresa; Disse, Bernd; Dusser, Joseph, Elizabeth; Kattenbeck, Sabine; Koenen-Bergmann, Michael; Pledger, Gordon; Calverley, Peter for the TIOSPIR (Tiotropium Safety and Performance in Respimat) Study Author Information
Asthma is a disease characterized by inflammation which affects both proximal and distal airways. We evaluated the prevalence of small airway obstruction (SAO) in group clinically stable asthmatics with normal forced expiratory volume first second (FEV1) FEV1/forced vital capacity (FVC) treated an association inhaled corticosteroids (ICSs) long acting β2-agonists (LABAs). Clinical evaluation included measurement dyspnea, asthma control test drug compliance.The SAO was estimated spirometry...