A5062137164- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Hematopoietic Stem Cell Transplantation
- Pneumocystis jirovecii pneumonia detection and treatment
- Genome Rearrangement Algorithms
- Fungal Infections and Studies
- Genomics and Phylogenetic Studies
- Algorithms and Data Compression
- Polyomavirus and related diseases
- Chromosomal and Genetic Variations
- Pneumonia and Respiratory Infections
- Infectious Diseases and Mycology
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- DNA and Biological Computing
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA and protein synthesis mechanisms
University of Geneva
2021-2025
Hôpital Beau-Séjour
2021-2025
University Hospital of Geneva
2022-2025
Tufts University
2025
Assistance Publique – Hôpitaux de Paris
2014-2024
Hôpital Saint-Louis
2014-2024
Université Paris Cité
2014-2024
Geneva College
2023-2024
Centre de Recherche Épidémiologie et Statistique
2015-2024
Sorbonne Paris Cité
2013-2024
The French pulmonary hypertension (PH) registry allows the survey of epidemiological trends. Isolated cases precapillary PH have been reported in patients who chronic myelogenous leukemia treated with tyrosine kinase inhibitor dasatinib.This study was designed to describe incident dasatinib-associated registry. From approval dasatinib (November 2006) September 30, 2010, 9 by at time diagnosis were identified. At diagnosis, had moderate severe functional and hemodynamic impairment. No other...
Acute respiratory failure (ARF) in patients with cancer is frequently a fatal event. To identify factors associated survival of admitted to an intensive care unit (ICU) for ARF, we conducted prospective 5-year observational study medical ICU teaching hospital Paris, France. The were 203 ARF mainly due infectious pneumonia (58%), but also noninfectious (9%), congestive heart (12%), and no identifiable cause (21%). We measured clinical characteristics mortality rates.ICU was 44.8% 47.8%....
To investigate the capacity of pulmonary vascular bed to acutely vasodilate, we examined in 35 consecutive patients with primary hypertension (PPH), hemodynamic effects incremental inhalation periods an air-NO mixture at different concentrations (10, 20, and 40 ppm), compared them those acute infusion prostacyclin (PGI2). An individual vasodilator response was defined by a fall total resistance (TPR) > or = 30% relative mean TPR baseline value. Thirteen were responders 22 nonresponders both...
Cytokines play an important role in granuloma formation, but the extent that cytokine profiles are similar different granulomatous diseases and whether differences histopathologic features of response results from production have not been evaluated. To investigate these questions, we used RT-PCR to quantify expression mRNAs coding for 16 cytokines lymph nodes patients with tuberculosis sarcoidosis control tissues, sought correlations between level granulomas. Expression a number (IL-1beta,...
Mucosa-associated lymphoid tissue-derived (MALT) lymphoma, a low grade B-cell extranodal is the most frequent subset of primary pulmonary lymphoma. Our objective was to evaluate initial extent disease and analyse characteristics long-term outcome these patients. All chest pathological departments teaching hospitals in Paris were contacted order identify patients with histological diagnosis lymphoma MALT subtype. 63 cases identified. The median age 60 yrs. 36% had no symptoms at diagnosis....
Tyrosine kinase inhibitors have revolutionized the treatment of chronic myeloid leukemia and are increasingly used for other indications. Fluid retention, however, including pleural effusions, a significant side effect imatinib, first-line leukemia. We investigated pulmonary complications in patients treated with dasatinib, novel multitargeted tyrosine inhibitor, as part clinical trial protocols. Of 40 who received dasatinib (70 mg twice daily) imatinib resistance or intolerance, 9 (22.5%)...
Telomerase reverse transcriptase (TERT) or telomerase RNA (TERC) gene mutation is a major monogenic cause of pulmonary fibrosis. Sequencing TERT/TERC genes proposed to patients with familial Little known about the possible predictors this and its impact on prognosis.We retrospectively analysed all genetic diagnoses made between 2007-2014 in We evaluated prevalence disease-associated variant (DAV), factors associated DAV, DAV survival.237 fibrosis (153 fibrosis, 84 telomere syndrome features...
This study aimed to describe the long-term outcomes of pulmonary arterial hypertension (PAH) induced by dasatinib.21 incident, right heart catheterisation-confirmed cases dasatinib-induced PAH were identified from French Pulmonary Hypertension Registry. Clinical and haemodynamic variables compared baseline last follow-up (median (range) 24 (1-81) months).Median age was 52 years 15 patients female (71%). 19 received dasatinib for chronic myelogenous leukaemia a median duration 42 (8-74)...
This review is the summary of a workshop on small airways disease, which took place in Porquerolles, France November 2011. The purpose this was to evidence (bronchiolar) involvement under various pathophysiological circumstances, excluding asthma and chronic obstructive pulmonary disease. Histopathological patterns associated with disease were reviewed, including cellular obliterative bronchiolitis. Many conditions have been airway infections, connective tissue diseases inflammatory bowel...
ABSTRACT This study was undertaken to examine the performance of Fungitell β-glucan (BG) assay, compare it with that galactomannan (GM) test for diagnosis invasive aspergillosis (IA) in patients hematological malignancies, and rates false-positive BG GM results due β-lactam antibiotics among sera Gram-positive or Gram-negative bacteremia selected from test. Serum samples 105 proven ( n = 14) probable 91) IA, 97 hematology at risk fungal infections, 50 healthy blood donors, 60 were used...
Abstract Early evidence suggests the efficacy of voriconazole for chronic pulmonary aspergillosis (CPA). We conducted a prospective, open, multicenter trial to evaluate and safety proven CPA in minimally or non-immunocompromised patients. Patients had confirmed by chest computed tomography (CT) and/or endoscopy, positive Aspergillus culture from respiratory sample, serologic test precipitins. received (200 mg twice daily) period 6–12 months were followed 6 after end therapy (EOT). The...
<h3>Importance</h3> Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post–lung bronchiolitis syndrome. <h3>Objective</h3> To evaluate if early administration can improve airflow decline–free survival HSCT. <h3>Design, Setting, Participants</h3> The ALLOZITHRO parallel-group trial conducted in 19 French academic...
Rationale: Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects.Objectives: To evaluate effectiveness tolerance of budesonide/formoterol as an alternative BOS HSCT.Methods: In this randomized, double-blind, placebo-controlled study, we randomly assigned 32 HSCT recipients with mild/severe to receive or placebo 6 months. The primary outcome...
Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung manifestations) and mortality (lung, gastrointestinal manifestations). Progress preventing severe morbidity chronic GVHD is limited by a complex incompletely understood biology lack prognostic biomarkers. Likewise, treatment advances for highly morbid manifestations remain hindered the absence effective...