A5083822022- Renal Transplantation Outcomes and Treatments
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Renal and Vascular Pathologies
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Cytomegalovirus and herpesvirus research
- Complement system in diseases
- Organ Donation and Transplantation
- Pneumothorax, Barotrauma, Emphysema
- Pneumocystis jirovecii pneumonia detection and treatment
- Renal Diseases and Glomerulopathies
- Nail Diseases and Treatments
- T-cell and B-cell Immunology
- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Fungal Biology and Applications
- Congenital Diaphragmatic Hernia Studies
- Organ Transplantation Techniques and Outcomes
- Dialysis and Renal Disease Management
- Pregnancy and Medication Impact
- Actinomycetales infections and treatment
- Mycobacterium research and diagnosis
- Blood groups and transfusion
Inserm
2020-2024
Université Paris Cité
2020-2024
University of Pittsburgh
2021-2024
Paris Cardiovascular Research Center
2020-2023
Centre Hospitalier Universitaire de Tours
2012-2021
Hôpital Bretonneau
2014-2021
University of Pittsburgh Medical Center
2020-2021
Université de Tours
2002-2020
Hôpital Tenon
2019
Sorbonne Université
2019
Abstract Objective To develop and validate an integrative system to predict long term kidney allograft failure. Design International cohort study. Setting Three cohorts including transplant recipients from 10 academic medical centres Europe the United States. Participants Derivation cohort: 4000 consecutive prospectively recruited in four French between 2005 2014. Validation cohorts: 2129 three 1428 North America, 2002 Additional validation randomised controlled trials ( NCT01079143 ,...
Abstract Background The COVID-19 pandemic has severely affected health systems and medical research worldwide but its impact on the global publication dynamics non-COVID-19 not been measured. We hypothesized that may have impacted scientific production of research. Methods conducted a comprehensive meta-research studies (original articles, letters case reports) published between 01/01/2019 01/01/2021 in 10 high-impact infectious disease journals (New England Journal Medicine, Lancet,...
BackgroundKidney allograft failure is a common cause of end-stage renal disease. We aimed to develop dynamic artificial intelligence approach enhance risk stratification for kidney transplant recipients by generating continuously refined predictions survival using updates clinical data.MethodsIn this observational study, we used data from adult transplants 18 academic centres in Europe, the USA, and South America, cohort patients six randomised controlled trials. The development comprised...
Pretransplantation adaptation of the daily dose tacrolimus to CYP3A5 genotype is associated with improved achievement target trough concentration (C0 ), but whether this improvement affects clinical outcomes unknown. In present study, we have evaluated long-term impact initial dosing according genotype: The transplantation 236 kidney transplant recipients included in Tactique study were retrospectively investigated over a period more than 5 years. patients randomly assigned receive at either...
Although antibody-mediated rejection (ABMR) has been long recognized as a leading cause of allograft failure after kidney transplantation, the cellular and molecular processes underlying induction deleterious donor-specific antibody (DSA) responses remain poorly understood.Using high-dimensional flow cytometry, in vitro assays, RNA sequencing, we concomitantly investigated role T follicular helper (TFH) cells B during ABMR 105 transplant recipients.There were 54 patients without DSAs; those...
Abstract Our objective was to determine whether the twice-weekly screening of high-risk hematology patients by Mucorales qPCR on serum affects prognosis mucormycosis. Results from all tests performed unit January 2017 December 2022 were analyzed. Patients with positive results classified as having proven, probable or ‘PCR-only’ One-month mortality for local cohort compared that a national cases mucormycosis collected French surveillance network invasive fungal disease (‘Réseau de...
Alloimmune responses driven by donor-specific antibodies (DSAs) can lead to antibody-mediated rejection (ABMR) in organ transplantation. Yet, the cellular states underlying alloreactive B cell and molecular components controlling them remain unclear. Using high-dimensional profiling of cells a cohort 96 kidney transplant recipients, we identified expanded numbers CD27+CD21– activated memory (AM) that expressed transcription factor T-bet patients who developed DSAs progressed ABMR. Notably,...
The differential pathogenicity of anti-HLA donor-specific antibodies (DSAs) is not fully understood. presence complement-binding DSAs helps in better defining the prognosis acute antibody-mediated rejection (ABMR). evolution these after treatment ABMR unknown.We included patients from French multicenter RITUX ERAH study diagnosed with within first year renal transplantation, circulating and treated randomly by rituximab or placebo (and intravenous immunoglobulins, plasma exchange). We...
Abstract Background Clinical decisions are mainly driven by the ability of physicians to apply risk stratification patients. However, this task is difficult as it requires complex integration numerous parameters and impacted patient heterogeneity. We sought evaluate transplant predict long-term allograft failure compare them a validated artificial intelligence (AI) prediction algorithm. Methods randomly selected 400 kidney recipients from qualified dataset 4000 For each patient, 44 features...
Summary Invasive pulmonary aspergillosis (IPA) is of particular concern to immunodeficient patients, whose mortality rates may exceed 80%. The development an animal model that faithfully reproduces the pathophysiology IPA would improve studies on diagnostic and therapeutic modes, use rats as a possible for seems have been largely overlooked. Such could be established with MicroSprayer IA‐1B ® . Male Sprague–Dawley (6–8 weeks old) were rendered by cyclophosphamide injections protein‐deficient...
Abstract We report the first successful use, to our knowledge, of fumagillin alone in a pediatric patient cure intestinal microsporidiosis liver‐kidney transplanted child. Detection E nterocytozoon bieneusi stool became negative from post‐therapeutic control, while digestive symptoms disappeared 4 days. During 9‐month follow‐up, polymerase chain reaction and direct examinations remained for microsporidia her feces. No major undesirable effects were noted during anti‐microsporidial therapy.