A5073313587- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal and Vascular Pathologies
- Pregnancy and Medication Impact
- Long-Term Effects of COVID-19
- Organ and Tissue Transplantation Research
- Viral-associated cancers and disorders
- Dialysis and Renal Disease Management
- Complement system in diseases
- Fungal Infections and Studies
- Blood groups and transfusion
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Pancreatitis Pathology and Treatment
- Pharmacological Effects and Toxicity Studies
Assistance Publique – Hôpitaux de Paris
2014-2024
Université Paris Cité
2011-2024
Bicêtre Hospital
2004-2024
Université Paris-Saclay
2005-2024
Hôpital Foch
2016-2022
Université de Versailles Saint-Quentin-en-Yvelines
2018-2021
Inserm
2005-2021
Centre de recherche en Epidémiologie et Santé des Populations
2018-2021
Délégation Paris 7
2021
Hôpital Paul-Brousse
2004-2021
Although thrombosis is considered the cardinal feature of antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In who require transplantation, often recur. The molecular pathways involved vasculopathy syndrome unknown, and adequate therapies lacking.We used double immunostaining to evaluate pathway activation mammalian target rapamycin complex (mTORC) nature cell proliferation vessels primary or secondary nephropathy....
Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim this registry-based observational study was to explore characteristics outcomes transplants included French nationwide Registry Solid Organ Transplant Recipients with Covid-19. Covid-19 diagnosed symptomatic patients who had positive PCR assay for SARS-CoV-2 or having typical lung lesions imaging. Clinical...
There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients nontransplant patients. We enrolled two groups patients hospitalized for COVID-19, that is, kidney (KTR) from French Registry Solid Organ Transplant (n = 306) a single-center cohort 795). An analysis was performed among subgroups matched age factors or mortality. Severe defined as admission (or transfer) to an intensive care unit, need mechanical ventilation, death. were...
Assessment of sex hormones in organ transplant recipients suggests that sirolimus may impair testicular function. The aim this study was to evaluate the frequency and severity sirolimus-associated alterations sperm parameters their impact on fathered pregnancy rate. An observational carried out male patients aged 20–40 years who received a kidney during 1995–2005. Patients were sent questionnaire by post, analysis proposed. rates according immunosuppressive regimen estimated compared using...
Background. Diarrhea of unspecified cause frequently occurs after renal transplantation and is usually ascribed to mycophenolic acid toxicity. Norovirus (NoV) sapovirus (SaV) have been sporadically reported chronic diarrhea in immunocompromised patients. Methods. We undertook a retrospective study (2008–2009) examine the clinical epidemiologic significance NoV SaV infections adult transplant recipients hospitalized for acute or diarrhea. Results. Ninety-six were at our institution during...
The specificity of chronic histological lesions induced by calcineurin inhibitors (CNI) is often questioned, but few studies have directly compared long-term in renal-transplant patients who received this treatment and those did not. We therefore conducted a retrospective study 141 kidney-transplant recipients treated with (n = 48) or without 93) cyclosporine (CsA) to compare the observed at 3-month, 24-month 10-year protocol biopsies. All elementary (glomerulosclerosis, interstitial...
Abstract Background The coronavirus disease 2019 (COVID-19) may be associated with kidney injury, which impact patient's prognosis. Methods We report a multicentric retrospective case series of patients COVID-19 who developed acute injury (AKI) and/or proteinuria and underwent biopsy in Paris its metropolitan area. Results Forty-seven (80.9% men) between 8 March 19 May 2020 were included. median age was 63 years (interquartile range 52–69). Comorbidities included hypertension (66.0%),...
Higher rates of severe COVID-19 have been reported in kidney transplant recipients (KTRs) compared to nontransplant patients. We aimed determine if poorer outcomes were specifically related chronic immunosuppression or underlying comorbidities. used a 1:1 propensity score-matching method compare survival and disease-free (defined as death and/or need for intensive care unit [ICU]) incidence hospitalized KTRs control patients between February 26 May 22, 2020. Patients matched risk factors...
IntroductionCoronavirus disease 2019 (COVID-19) represents a serious threat to patients on maintenance dialysis. The clinical setting, mortality rate, and prognostic factors in these have not been well established.MethodsWe included all dialyzed with COVID-19 referred our dialysis center between March 11 April 11, 2020. Data were obtained through the review of medical records censored at time data cutoff, May 2020.ResultsForty-four unit during epidemic. Median age was 61 years (interquartile...
No treatment has consistently induced long-term remission of proteinuria in adult patients with focal segmental glomerulosclerosis (FSGS) recurrence after kidney transplantation. We undertook an open-label, nonrandomized pilot trial intensive and prolonged FSGS recurrence. Over 18-month period, 10 transplant recipients received concomitantly high-dose steroids, intravenous cyclosporine for 14 days followed by oral therapy, course plasma exchanges (PE). compared this those a control group 19...
Persistence of donor-specific anti-HLA antibodies (DSA) associated with antibody-mediated graft injuries following kidney transplantation predicts evolution toward chronic humoral rejection and reduced survival. Targeting plasma cells, the main antibody-producing proteasome inhibitor bortezomib may be a promising desensitization strategy. We evaluated in vivo efficacy one cycle (1.3 mg/m(2)x 4 doses), used as sole therapy, four renal transplant recipients experiencing subacute persisting DSA...
In Brief Background There is an increasing number of anti-HLA sensitized and highly renal transplant candidates on waiting lists, the presence donor-specific alloantibodies (DSAs) at time transplantation leads to acute chronic antibody-mediated rejection (AMR). Acceptable short-term outcomes have been described, notably because desensitization protocols, but mid- long-term data are still required. Methods Our high immunologic risk program included 95 patients with peak or day 0 DSA levels...
The urinary chemokines CXCL9 and CXCL10 are promising noninvasive diagnostic markers of acute rejection (AR) in kidney recipients, but their levels might be confounded by tract infection (UTI) BK virus (BKV) reactivation. Multiparametric model development validation addressed these confounding factors a training set 391 samples, optimizing the performance chemokines. CXCL9/creatinine increased UTI BKV viremia with or without nephropathy (BKVN) (no UTI/leukocyturia/UTI: -0.10/1.61/2.09, P =...
Non-Hodgkin's lymphoma is the second most frequent neoplasia following solid-organ transplantation. The objective of this study to describe clinical, histologic, and radiologic features primary posttransplantation brain lymphomas (PTBL) in addition their outcome.Twenty-five kidney transplant patients with histologically proven PTBL from 11 French centers were retrospectively investigated.Immunosuppressive regimen included induction antithymocyte globulins (ATG) 20 patients. Median overall...
Introduction. Recurrence of nephrotic-range proteinuria in patients with idiopathic nephrotic syndrome (INS) and focal segmental glomerulosclerosis (FSGS) on native kidneys is associated poor graft survival. Identification risk factors for recurrence therefore an important issue. In 2004, Columbia University introduced a histological classification FSGS that identifies five mutually exclusive variants. non-transplant patients, the appears to predict outcome response treatment better than...
It has been suggested that dual kidney transplantation (DKT) improves outcomes for expanded criteria donor (ECD) kidneys. However, no allocation to single or have assessed prospectively. The strategy of DKT remains underused and potentially eligible kidneys are frequently discarded. We prospectively compared 81 70 transplant (SKT) receiving grafts from ECD donors aged >65 years, allocated according estimated glomerular filtration rate (eGFR): if eGFR between 30 60 mL/min, SKT greater than...
We monitored the urinary C-X-C motif chemokine (CXCL)9 and CXCL10 levels in 1722 urine samples from 300 consecutive kidney recipients collected during first posttransplantation year assessed their predictive value for subsequent acute rejection (AR). The trajectories of showed an early increase at 1 month (p = 0.0005) 3 months 0.0009) patients who subsequently developed AR. At year, AR-free allograft survival rates were 90% 54% with CXCL10:creatinine (CXCL10:Cr) <2.79 ng/mmoL >2.79 month,...
Our objectives were to evaluate kidney transplantation survival benefit in people aged ≥70 who receiving renal replacement therapy (RRT) and identify their risk factors for posttransplant mortality. This study included all patients the national French Renal Epidemiology Information Network registry started RRT between 2002 2013 at age ≥70. Mortality was compared with transplants; on waiting list; dialysis matched age, gender, comorbidities, time dialysis. Of 41 716 elderly starting RRT, 1219...
Light chain (AL) and secondary (AA) amyloidosis usually present as a systemic disease frequently involving the kidney leading to ESRD. Data regarding patients with AA or AL undergoing dialysis remain scarce.We retrospectively studied who started in five French centers between January 1, 1995 December 31, 2005.We identified 19 20 dialysis. Patients had shorter time from diagnosis (25.2 versus 69.3 mo, P < 0.05) more extrarenal amyloidosis, especially cardiac (63.2 5%, 0.0001). Mean duration...