A5039789883- Renal Transplantation Outcomes and Treatments
- Health, Medicine and Society
- Organ Donation and Transplantation
- Healthcare Systems and Practices
- Palliative Care and End-of-Life Issues
- Viral-associated cancers and disorders
- Renal and Vascular Pathologies
- Ethics in Clinical Research
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Ethics in medical practice
- Neurological Complications and Syndromes
- Health Systems, Economic Evaluations, Quality of Life
- Lymphoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Biomedical Ethics and Regulation
- Blood donation and transfusion practices
- Pregnancy and Medication Impact
- Antifungal resistance and susceptibility
- Pharmacological Effects and Toxicity Studies
- Artificial Intelligence in Healthcare and Education
- Pediatric Urology and Nephrology Studies
Inserm
2013-2025
Sorbonne Université
2013-2025
Hôpital Necker-Enfants Malades
2015-2025
Université Paris Cité
2016-2025
Assistance Publique – Hôpitaux de Paris
2013-2025
Centre de Recherche des Cordeliers
2019-2025
Hôpital Corentin-Celton
2022
Délégation Paris 5
2012-2021
Sorbonne Paris Cité
2012-2021
Institute of Medical Ethics
2017
Artificial intelligence (AI), with its seemingly limitless power, holds the promise to truly revolutionize patient healthcare. However, discourse carried out in public does not always correlate actual impact. Thus, we aimed obtain both an overview of how French health professionals perceive arrival AI daily practice and perception other actors involved have overall understanding this issue.
Background. Sirolimus, a promising new immunosuppressive drug for organ transplantation, is currently associated with side effects, such as thrombocytopenia and hyperlipidemia. Methods. Eight renal transplant recipients, who developed unexplained interstitial pneumonitis during sirolimus therapy, were extensively re-screened all causes of pneumonitis. Results. Interstitial was constantly characterized by bilateral infiltrates on chest x-rays lung computed tomography scans, marked general...
Background. The long-term impact of hepatitis C virus (HCV) infection in renal transplant recipients remains controversial. We report here our experience, a homogeneous single center, 499 patients with fairly long follow-up. Methods. retrospectively studied B virus-negative who received an initial cadaver donor kidney transplantation at Necker Hospital between January 1, 1979 and December 31, 1994, graft or patient survival least 6 months. Anti-HCV antibodies were detected time 112 (22%)....
Sirolimus is an immunosuppressive drug recently developed for organ transplantation. Its mechanism of action, independent calcineurin, different from that cyclosporine and tacrolimus, two calcineurin inhibitors (CIs). Because the toxicity CIs partly result blockade, sirolimus exhibits a profile. In this study, we evaluated profile, frequency, severity cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy.A systematic in-depth evaluation skin, mucous...
Abstract Two species of Listeria are pathogenic; L. monocytogenes infects humans and animals, ivanovii has been considered to infect ruminants only. We report ivanovii–associated gastroenteritis bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. is thus an enteric opportunistic human pathogen.
PURPOSE: Prognostic studies of posttransplantation lymphoproliferative disorders (PTLDs) are hindered by the small number cases at each transplant center. We analyzed prognostic factors and long-term outcome according to clinical manifestations, pathologic features, treatment investigated value non-Hodgkin’s lymphoma International Index (IPI) in 61 patients with PTLD. PATIENTS AND METHODS: studied two institutions who developed PTLD influencing complete remission survival rates. RESULTS: In...
Background: Interstitial pneumonitis is an ill-defined side effect of sirolimus, a new immunosuppressant drug recently introduced for patients having organ transplantation. Objective: To evaluate clinical and laboratory features sirolimus-associated pneumonitis. Design: Case series. Setting: 1 transplantation center in Paris, France. Patients: 24 who had renal developed pneumonitis, including 8 previously reported. Measurements: Symptoms; tests, bronchoalveolar fluid analysis; computed...
Assessment of sex hormones in organ transplant recipients suggests that sirolimus may impair testicular function. The aim this study was to evaluate the frequency and severity sirolimus-associated alterations sperm parameters their impact on fathered pregnancy rate. An observational carried out male patients aged 20–40 years who received a kidney during 1995–2005. Patients were sent questionnaire by post, analysis proposed. rates according immunosuppressive regimen estimated compared using...
Background. Diarrhea of unspecified cause frequently occurs after renal transplantation and is usually ascribed to mycophenolic acid toxicity. Norovirus (NoV) sapovirus (SaV) have been sporadically reported chronic diarrhea in immunocompromised patients. Methods. We undertook a retrospective study (2008–2009) examine the clinical epidemiologic significance NoV SaV infections adult transplant recipients hospitalized for acute or diarrhea. Results. Ninety-six were at our institution during...
Post-transplantation lymphoproliferative disorder (PTLD) is associated with significant mortality in kidney transplant recipients. We conducted a prospective survey of the occurrence PTLD French nationwide population adult recipients over 10 years.A registry was established to cover and prospectively enroll all who developed between January 1, 1998, December 31, 2007. Five hundred patient cases were referred registry. The prognostic factors for investigated using Kaplan-Meier Cox...
In an attempt to evaluate the long-term reciprocal impact of renal transplantation on hepatitis B virus infection, we analyzed clinical, virologic, and pathologic features 151 HBsAg-positive kidney transplant recipients. The spontaneous disappearance rates HBsAg, HBeAg, HBV DNA during a median follow-up 125 months (range 1 320) were 3, 30.6, 3%, respectively, figures lower than in general population. A high rate persistent viral replication (50%) reactivation (30%) was noted. Noteworthy...
The aim of the present study was to describe histologic features disclosed by protocol kidney transplant biopsies in patients who experienced neither acute rejection nor renal failure during 2 years after transplantation.We studied 10 recipients HLA-identical kidneys from living-related donors and 31 cadaveric kidneys. They were selected because, transplantation, they did not experience clinical or chronic rejection, their function normal stable, underwent a biopsy at 3 months...
Objectives: To examine the hemodynamic and metabolic characteristics ICU outcome of septic shock in patients with cirrhosis. Design: Prospective, comparative study. Measurements performed first 24 hrs shock. Setting: A general hospital ICU. Patients: Twelve cirrhosis 23 without admitted for Main Results: Arterial pressure was measured using an arterial catheter. Pulmonary right atrial pressures were by a pulmonary artery Cardiac output determined thermodilution method. L-lactate plasma...
Background.Infections of renal grafts with Candida species can induce life-threatening complications in the recipient.
Background. Voriconazole long-term therapy is suspected to induce cutaneous squamous cell carcinoma (SCC), as suggested by 18 case reports worldwide and 3 retrospective studies. Methods. To better characterize the natural history of these potentially voriconazole-associated tumors, a nationwide call for notification skin cancers other lesions observed between 2002 2012 in patients treated voriconazole was launched France. A multidisciplinary committee evaluated involvement each case....
In France, decisions to limit treatment fall under the Leonetti law adopted in 2005. Leading figures from French world of politics, science, and justice recently claimed for amendments law, considering it incomplete. This study, conducted before any legislative change, aimed investigate procedural aspects withholding/withdrawing ICUs their adequacy with existing law. The characteristics patients qualified a withholding/withdrawal procedure were prospectively collected 43 ICUs. study period...
Since 2006, the genetic testing company 23andMe has collected biological samples, self-reported information, and consent documents for biobanking research from more than 1,000,000 individuals (90 % participating in research), through a direct-to-consumer (DTC) online genetic-testing service providing ancestry report health report. However, on November 22, 2013, Food Drug Administration (FDA) halted sale of testing, grounds that was not acting accordance with federal law, by selling tests...
Non-Hodgkin's lymphoma is the second most frequent neoplasia following solid-organ transplantation. The objective of this study to describe clinical, histologic, and radiologic features primary posttransplantation brain lymphomas (PTBL) in addition their outcome.Twenty-five kidney transplant patients with histologically proven PTBL from 11 French centers were retrospectively investigated.Immunosuppressive regimen included induction antithymocyte globulins (ATG) 20 patients. Median overall...
Background. The responsibility of sirolimus (SRL) for postrenal transplant anemia has never been proven, because SRL is usually combined with myelotoxic drugs, and the high incidence in posttransplant period. Methods. We retrospectively analyzed 46 renal recipients, who had switched from calcineurin inhibitors to biopsy-proven chronic allograft nephropathy. Results. mean decrease hemoglobin (Hb) after introduction was 2.8 g/dl. 24 patients, whose Hb fell by ≥2 g/dl, displayed microcytic...