A5045454594- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Molecular Junctions and Nanostructures
- Organic Electronics and Photovoltaics
- Organ Transplantation Techniques and Outcomes
- Conducting polymers and applications
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Quantum Dots Synthesis And Properties
- Thin-Film Transistor Technologies
- Chronic Kidney Disease and Diabetes
- Head and Neck Cancer Studies
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Sensor and Energy Harvesting Materials
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immune Cell Function and Interaction
- Organ and Tissue Transplantation Research
- Dialysis and Renal Disease Management
- Polyomavirus and related diseases
Interfaces Traitements Organisation et Dynamique des Systèmes
2016-2025
Université Paris Cité
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Inserm
2011-2023
Collaborative Group (United States)
2023
Institut des Maladies Génétiques Imagine
2023
University of Zurich
2023
Centre Hospitalier Universitaire de Nîmes
2014-2023
Hôpital Ambroise-Paré
2023
Université de Versailles Saint-Quentin-en-Yvelines
2021-2023
Sirolimus (rapamycin) is a potent immunosuppressant with mechanism of action different from cyclosporine (CsA) or tacrolimus.In 11 European centers, first cadaveric renal allograft recipients were randomized to CsA (n=42) sirolimus (n=41). Dosing these agents was concentration-controlled and open-labeled. All patients received corticosteroids azathioprine.At 12 months, graft survival (98% vs. 90% CsA), patient (100% 98%), incidence biopsy-confirmed acute rejection (41% 38%) similar. Serum...
Renal transplantation is the standard of care for patients with end-stage renal disease. Although maintenance immunosuppression calcineurin inhibitors yields excellent one-year survival, it associated over long term high rates death and graft loss, owing in part to adverse renal, cardiovascular, metabolic effects these agents. The use potentially less toxic agents, such as belatacept, a selective blocker T-cell activation, may improve outcomes.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGrowth and Characterization of Sexithiophene Single CrystalsGilles Horowitz, Bernard Bachet, Abderrahim Yassar, Philippe Lang, Frederic Demanze, Jean-Louis Fave, Francis GarnierCite this: Chem. Mater. 1995, 7, 1337–1341Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/cm00055a010https://doi.org/10.1021/cm00055a010research-articleACS PublicationsRequest...
Purpose To compare the efficacy and safety of induction chemotherapy (ICT) followed by chemoradiotherapy (CRT) or bioradiotherapy (BRT) for larynx preservation (LP). Patients Methods Previously untreated patients with stage III to IV larynx/hypopharynx squamous cell carcinoma received three cycles ICT—docetaxel cisplatin 75 mg/m 2 each on day 1 fluorouracil 750 per days through 5. Poor responders (< 50% response) underwent salvage surgery. Responders (≥ were randomly assigned conventional...
The clinical profile of belatacept in kidney transplant recipients was evaluated to determine if earlier results the BENEFIT study were sustained at 3 years. is a randomized year, phase III adults receiving from living or standard criteria deceased donor. Patients more (MI) less intensive (LI) regimen belatacept, cyclosporine. 471/666 patients completed ≥3 years therapy. A total 92% (MI), (LI), and 89% (cyclosporine) survived with functioning graft. mean calculated GFR (cGFR) ∼21 mL/min/1.73...
Recipients of extended-criteria donor (ECD) kidneys have poorer long-term outcomes compared to standard-criteria kidney recipients. We report 3-year from a randomized, phase III study in recipients de novo ECD (n = 543) assigned (1:1:1) either more intensive (MI) or less (LI) belatacept regimen, cyclosporine. Three hundred twenty-three patients completed treatment by year 3. Patient survival with functioning graft was comparable between groups (80% MI, 82% LI, 80% cyclosporine). Mean...
Abstract NK cells express cell surface receptors for MHC class I proteins (KIR). Engagement of these inhibits cytotoxic programs. KIR can be expressed on T cells, and their engagement also results in inhibition effector functions initiated by the CD3/TCR complex. While human genes belong to Ig gene superfamily, mouse a family dimeric lectins. Despite distinct evolutionary origins, we show here that both HLA-Cw3-specific p58.183 H-2D d/k-specific Ly49A recruit same protein tyrosine...
Growing organic semiconductors on dielectrics with different surface energies and dielectric constants results in striking changes of the film morphology (Figure, right). Ambipolar transport is reported pentacene transistors a PVA gate (left). The current–voltage characteristics correlate capacitance–voltage investigations metal–insulator–semiconductor structures.
Composite tissue allotransplantations can be indicated when autologous transfers fail to restore human appearance. We report the reproducibility, difficulties, serious adverse events and outcomes of our patients. Five patients were included in a registered clinical research protocol after thorough screenings assessed by an independent expert committee systematically discussing alternative options. One patient suffered from plexiform neurofibromas, two third degree burns gunshot injuries....
Nondepleting anti-CD25 monoclonal antibodies (daclizumab) and depleting polyclonal antithymocyte globulin (Thymoglobulin) both prevent acute rejection, but these therapies have not been directly compared in a high-risk, HLA-sensitized renal transplant population. We randomly assigned 227 patients, who were about to receive kidney graft from deceased donor, either Thymoglobulin or daclizumab if they met one of the following risk factors: current panel reactive (PRA) >30%; peak PRA >50%; loss...
Platinum nanoparticles with a mean size of 1.7 nm were synthesized by reduction in sodium acetate solution 1,2-ethanediol. The particles then functionalized dodecylamine, dodecanethiol, and ω-mercapto-undecanoic acid (MUDA). Fourier transform infrared (FTIR) spectroscopy X-ray photoelectron (XPS) showed important variations the particle surface state functionalization whereas their structure differs only slightly. Platinum-to-sulfur charge transfer inferred from XPS thiol-coated enabled...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExciton Coupling Effects in the Absorption and Photoluminescence of Sexithiophene DerivativesA. Yassar, G. Horowitz, P. Valat, V. Wintgens, M. Hmyene, F. Deloffre, Srivastava, Lang, GarnierCite this: J. Phys. Chem. 1995, 99, 22, 9155–9159Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/j100022a031https://doi.org/10.1021/j100022a031research-articleACS...
Belatacept is a first-in-class co-stimulation blocker in development for primary maintenance immunosuppression. A Phase II study comparing belatacept with cyclosporine (CsA) prevention of acute rejection and protection renal function kidney transplant recipients demonstrated similar efficacy significantly higher measured GFR at 1 year belatacept, but the incidence posttransplantation lymphoproliferative disorder was higher. Here, we present results extension this trial, which aimed to assess...
Cardiovascular disease, the most common cause of death with a functioning graft among kidney transplant recipients, can be exacerbated by immunosuppressive drugs, particularly calcineurin inhibitors. Belatacept, selective co-stimulation blocker, may provide better cardiovascular/metabolic risk profile than current immunosuppressants.Cardiovascular and metabolic endpoints from two Phase III studies (BENEFIT BENEFIT-EXT) belatacept-based regimens in recipients were assessed at month 12. Each...
Summary Background and objectives Renal infarction is an arterial vascular event that may cause irreversible damage to kidney tissues. This study describes the clinical characteristics of patients with renal according underlying mechanism injury. Design, setting, participants, & measurements retrospectively identified 94 diagnosed between 1989 2011 aim highlighting potential correlations demographic, clinical, biologic etiology infarction. Four groups were identified: cardiac origin...
Background Treatment of acute antibody-mediated rejection (AMR) is based on a combination plasma exchange (PE), IVIg, corticosteroids (CS), and rituximab, but the place rituximab not clearly specified in absence randomized trials. Methods In this phase III, multicenter, double-blind, placebo-controlled trial, we randomly assigned patients with biopsy-proven AMR to receive (375 mg/m2) or placebo at day 5. All received PE, CS. The primary endpoint was composite graft loss no improvement renal...
We have measured the polarization and incident angle dependence of Surface-Enhanced Raman Scattering (SERS) signal a nile blue monolayer adsorbed on flat gold surface. Comparisons with predictions electromagnetic (EM) theory indicate that molecules are predominantly These results provide most direct demonstration concept surface selection rules in SERS, further confirm validity SERS-EM model beyond |E|4-approximation.
Post-transplantation lymphoproliferative disorder (PTLD) is associated with significant mortality in kidney transplant recipients. We conducted a prospective survey of the occurrence PTLD French nationwide population adult recipients over 10 years.A registry was established to cover and prospectively enroll all who developed between January 1, 1998, December 31, 2007. Five hundred patient cases were referred registry. The prognostic factors for investigated using Kaplan-Meier Cox...