Damien Roos‐Weil
A5083826444- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Cutaneous lymphoproliferative disorders research
- Advanced Breast Cancer Therapies
- Fungal Infections and Studies
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Cancer Treatment and Pharmacology
- HIV/AIDS drug development and treatment
- Peripheral Neuropathies and Disorders
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Pitié-Salpêtrière Hospital
2016-2025
Centre de Recherche des Cordeliers
2019-2024
Inserm
2015-2024
Université Paris Cité
2012-2024
Délégation Paris 5
2019-2024
Sorbonne Paris Cité
2019-2024
Hôpital Charles-Foix
2023-2024
Centre Hospitalier de Saint-Brieuc
2023
Abstract The prognosis of relapsed primary central nervous system lymphoma (PCNSL) remains dismal. CAR T‐cells are a major contributor to systemic lymphomas, but their use in PCNSL is limited. From the LOC network database, we retrospectively selected who had leukapheresis for CAR‐T cells from third line treatment, and, as controls, treated with any at least and considered not eligible ASCT. Twenty‐seven patients (median age: 68, median three previous lines, including ASCT 14/27)...
Background. Diarrhea of unspecified cause frequently occurs after renal transplantation and is usually ascribed to mycophenolic acid toxicity. Norovirus (NoV) sapovirus (SaV) have been sporadically reported chronic diarrhea in immunocompromised patients. Methods. We undertook a retrospective study (2008–2009) examine the clinical epidemiologic significance NoV SaV infections adult transplant recipients hospitalized for acute or diarrhea. Results. Ninety-six were at our institution during...
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed nationwide network to collect data from new cases diagnosed in France. In retrospective, observational study of 86 patients (2000-2013), described clinical biological focusing on morphologies immunophenotype. We found expression markers associated with origin (HLA-DRhigh, CD303+, CD304+, cTCL1+) plus CD4 CD56 frequent isolated the myeloid, B-, T-lymphoid lineages, whereas...
Neoplasms involving plasmacytoid dendritic cells (pDC) include blastic pDC neoplasms (BPDCN) and other proliferations, where are associated with myeloid malignancies: most frequently chronic myelomonocytic leukemia (CMML) but also acute (AML), hereafter named pDC-AML. We aimed to determine the reactive or neoplastic origin of in pDC-AML, their link CD34+ blasts, monocytes conventional DC (cDC) same sample, by phenotypic molecular analyses (targeted next-generation sequencing, 70 genes)....
Our aim was to assess the real-world effectiveness of immune checkpoint inhibitors for treatment patients with progressive multifocal leukoencephalopathy (PML).We conducted a multicenter survey compiling retrospective data from 79 PML patients, including 38 published cases and 41 unpublished cases, who received as add-on standard care. One-year follow-up were analyzed determine clinical outcomes safety profile. Logistic regression used identify variables associated 1-year...
Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We characterize 58 primary human RS samples by genome-wide DNA methylation and whole-transcriptome profiling. Our comprehensive approach determines profile unravels a CLL epigenetic imprint, allowing CLL-RS clonal relationship assessment without need initial tumor DNA. methylation- transcriptomic-based classifiers were developed,...
We report a multicenter controlled trial comparing renal recovery and tolerance profile of doublet versus triplet bortezomib-based regimens in patients with initial myeloma cast nephropathy (CN) acute kidney injury (AKI) without need for dialysis.After symptomatic measures high-dose dexamethasone, were randomly assigned to receive bortezomib plus dexamethasone (BD), or BD cyclophosphamide (C-BD). In < 50% reduction serum free light chains (sFLCs) after 3 cycles, chemotherapy was reinforced...
While Waldenström macroglobulinemia (WM) is characterized by an almost unifying mutation in MYD88, clinical presentation at diagnosis and response to therapy can be widely different among WM patients. Current prognostic tools only partially address this heterogeneity. Limited data compiling both molecular cytogenetic information have been used risk prognostication WM. To investigate the impact of genetic alterations WM, we evaluated abnormalities chromosome banding analyses, FISH targeted...