Lucile Couronné
A5053671163- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cardiac tumors and thrombi
- Veterinary Oncology Research
- RNA modifications and cancer
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Kruppel-like factors research
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
Université Paris Cité
2014-2025
Inserm
2015-2025
Assistance Publique – Hôpitaux de Paris
2014-2024
Institut des Maladies Génétiques Imagine
2015-2024
Hôpital Necker-Enfants Malades
2009-2024
Institut Necker Enfants Malades
2021-2023
Cohort (United Kingdom)
2023
Cohortes épidémiologiques en population
2023
Laboratory of Excellence GR-Ex
2020-2021
Délégation Paris 5
2014-2018
Viral infection induces potent cellular immunity and activated intracellular signaling, which may dictate the driver events involved in immune escape clonal selection of virus-associated cancers, including Epstein-Barr virus (EBV)-positive lymphomas. Here, we thoroughly interrogated PD-L1/PD-L2-involving somatic aberrations 384 samples from various lymphoma subtypes using high-throughput sequencing, particularly focusing on A high frequency genetic was observed EBV-positive lymphomas [33...
Significance Guanine nucleotide exchange factor VAV1 encodes an adaptor and signal transduction with important roles in T-cell receptor signaling. This study identifies activating recurrent mutations fusions peripheral lymphomas, directly establishing oncogenic role for constitutive signaling the pathogenesis of this disease.
Abstract Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing EWSR1 with FLI1. An estimated 30% of tumors also display genetic alterations in STAG2, TP53, or CDKN2A (SPC). Numerous attempts to develop relevant models from primary human cells have been unsuccessful faithfully recapitulating the phenotypic, transcriptomic, and epigenetic features sarcoma. In this study, engineering t(11;22)(q24;q12) translocation together a combination SPC mutations, we...
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B,...
STAT3 protein phosphorylation is a frequent event in various hematologic malignancies and solid tumors. Acquired mutations have been recently identified 40% of patients with T-cell large granular lymphocytic leukemia, rare disorder. In this study, we investigated the mutational status series lymphoid myeloid diseases. were 1.6% (4 258) neoplasms, 2.5% (2 79) diffuse B-cell lymphoma but no other (0 104) or 96). Functional vitro assays indicated that STAT3Y640F mutation leads to constitutive...
Abstract We report the case of a patient with history Epstein–Barr virus‐positive large B‐cell lymphoma, who relapsed an angioimmunoblastic T‐cell lymphoma (AITL) associated chronic myelomonocytic leukaemia (CMML). performed targeted next‐generation sequencing on CMML and AITL DNA, which revealed mutations TET2 , DNMT3A SRSF2 NRAS IDH1 thus confirming that spectrum share similarities myeloid disorders. The frequencies TET2/DNMT3A variants could support hypothesis occurred in early progenitor...
Abstract Background Differentiation of low‐grade intestinal T‐cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists. Objective Characterize histologic, immunohistochemical, and molecular features LGITL LPE. Animals Forty‐four client‐owned cats, 22 diagnosed with Methods Prospective, cohort study. Clinical suspicion or LPE was based on persistent gastrointestinal signs, unresponsive to empirical treatments. All underwent standardized...
Abstract Natural killer/T-cell lymphomas (NKTCL) represent rare and aggressive lymphoid malignancies. Patients (pts) with relapsed/refractory disease after Asparaginase (ASPA)-based chemotherapy have a dismal prognosis. To better define the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT), we conducted retrospective analysis data shared European Society for Blood Marrow Transplantation (EBMT) cooperating Asian centers. We identified 135 pts who received allo-HSCT...