A5004539401- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Hematopoietic Stem Cell Transplantation
- Kruppel-like factors research
- Blood disorders and treatments
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Erythrocyte Function and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- Telomeres, Telomerase, and Senescence
- Hemoglobinopathies and Related Disorders
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
Hôpital Saint-Antoine
2014-2024
Sorbonne Université
2014-2024
Inserm
2014-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Centre de Recherche Saint-Antoine
2016-2024
Institut Carnot ARTS
2023-2024
Centre National de la Recherche Scientifique
2000-2023
Institut Gustave Roussy
2003-2022
Université Paris-Saclay
2000-2022
Hôpital Saint-Louis
2001-2022
The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. mechanisms underlying these not well defined.We conducted a combination molecular, cytogenetic, comparative-genomic-hybridization, single-nucleotide-polymorphism analyses to identify candidate tumor-suppressor gene common patients syndromes, disorders, acute leukemia (AML). coding sequence this gene, TET2, was determined in 320 patients. We analyzed the consequences...
Abstract Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem (LSC). To validate this hypothesis vivo, we developed a clinically relevant chemotherapeutic approach treating patient-derived xenografts (PDX) with cytarabine (AraC). AraC residual AML neither immature, nor LSCs. Strikingly, AraC-resistant preexisting and persisting displayed high levels of reactive oxygen species, showed increased mitochondrial mass,...
Abstract In acute myeloid leukaemia (AML) initiating pre-leukaemic lesions can be identified through three major hallmarks: their early occurrence in the clone, persistence at relapse and ability to initiate multilineage haematopoietic repopulation vivo . Here we analyse clonal composition of a series AML these characteristics. We find that not only DNMT3A mutations, but also TET2 , ASXL1 core-binding factor MLL translocations, as well del(20q) mostly fulfil criteria. When eradicated by...
Abstract Indirect somatic genetic rescue (SGR) of a germline mutation is thought to be rare in inherited Mendelian disorders. Here, we establish that acquired mutations the EIF6 gene are frequent mechanism SGR Shwachman-Diamond syndrome (SDS), leukemia predisposition disorder caused by defect ribosome assembly. Biallelic SBDS or EFL1 genes SDS impair release anti-association factor eIF6 from 60S ribosomal subunit, key step translational activation ribosomes. identify diverse mosaic events...
Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being fundamental processes leading to malignancy its many manifestations (neoangiogenesis, evasion immune system, metastasis, resistance therapies). Historically, little attention placed on applications evolutionary biology understanding controlling neoplastic progression prevent therapeutic failures. This is now beginning change, there growing international...
Acute myeloid leukemia (AML) is characterized by the accumulation of malignant blasts with impaired differentiation programs caused recurrent mutations, such as isocitrate dehydrogenase (IDH) mutations found in 15% AML patients. These result production oncometabolite (R)-2-hydroxyglutarate (2-HG), leading to a hypermethylation phenotype that dysregulates hematopoietic differentiation. In this study, we identified mutant R132H IDH1-specific gene signatures regulated key transcription factors,...
The results of conventional allogeneic stem cell transplantation (SCT) in refractory hematologic malignancies are poor. Sequential strategies have shown promising acute myelogenous leukemia (AML), but not been validated a haploidentical (Haplo) transplant setting. We developed new sequential approach combining chemotherapy with broad antitumor activity (thiotepa 10 mg/kg, etoposide 400 mg/m2, and cyclophosphamide 1600 mg/m2 from day -15 to -10), followed after 3 days rest by...
VEXAS syndrome: still expanding the clinical phenotype Artem Oganesyan, Oganesyan Department of Hematology and Transfusion Medicine, National Institute Health, Armenia Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincent Jachiet, Jachiet Service de Médecine Interne et Inflammation-Immunopathology-Biotherapy Department, Hôpital Saint Antoine Francois Chasset, Chasset Dermatologie, Tenon Pierre Hirsch, Hirsch D’hématologie Biologique Mehdi Hage-Sleiman,...
Germline GATA2 mutations predispose to myeloid malignancies resulting from the progressive acquisition of additional somatic mutations. Here we describe clinical and biological features 78 GATA2-deficient patients. Hematopoietic stem progenitor cell phenotypic characterization revealed an exhaustion progenitors. Somatic in STAG2, ASXL1 SETBP1 genes along with cytogenetic abnormalities (monosomy 7, trisomy 8, der(1;7)) occurred frequently patients germline Patients were classified into three...