Éric Lippert
A5073081349- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hemoglobinopathies and Related Disorders
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- RNA modifications and cancer
- Blood disorders and treatments
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
Centre Hospitalier Régional Universitaire de Brest
2016-2024
Inserm
2012-2024
Université de Bretagne Occidentale
2016-2024
Hôpital Maison Blanche
2017-2024
École nationale d'ingénieurs de Brest
2019-2022
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2016-2022
Établissement Français du Sang
2020
Génétique, Génomique Fonctionnelle et Biotechnologies
2015-2018
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2012-2018
Université de Bordeaux
2008-2017
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present data obtained from 2345 leukemia patients. Genomic breakpoints within MLL involved translocation partner genes (TPGs) were determined 11 novel TPGs identified. Thus, a total 135 different have been identified so far, which 94 now characterized at molecular level. In all, 35 out these occur recurrently, but only 9 specific fusions account for...
Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used long-distance inverse-polymerase chain reaction to characterize chromosomal rearrangement individual leukemia patients. present data molecular characterization 1590 MLL-rearranged biopsy samples obtained from The precise localization genomic breakpoints within involved translocation partner genes (TPGs) were determined...
Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2;11)(p21;q23) translocation has been cloned 19 cases MDS AML. In addition to this, we have shown this is associated with a strong up-regulation miR-125b (from 6- 90-fold). vitro experiments revealed was able interfere primary human CD34+ cell differentiation, also inhibited terminal (monocytic...
Reliable detection of JAK2-V617F is critical for accurate diagnosis myeloproliferative neoplasms (MPNs); in addition, sensitive mutation-specific assays can be applied to monitor disease response. However, there has been no consistent approach detection, with varying markedly performance, affecting clinical utility. Therefore, we established a network 12 laboratories from seven countries systematically evaluate nine different DNA-based quantitative PCR (qPCR) assays, including those...
Abstract We aimed to study the prognostic impact of mutational landscape in primary and secondary myelofibrosis. The included 479 patients with myelofibrosis recruited from 24 French Intergroup Myeloproliferative Neoplasms (FIM) centers. molecular was studied by high-throughput sequencing 77 genes. A Bayesian network allowed identification genomic groups whose a multistate model considering transitions 3 conditions: myelofibrosis, acute leukemia, death. Results were validated using an...
Background Refractory anemia with ring sideroblasts associated marked thrombocytosis was proposed as a provisional entity in the 2001 World Health Organization classification of myeloid neoplasms and also 2008 version, but its existence single is contested. We wish to define clinical features this rare myelodysplastic/myeloproliferative neoplasm compare outcome that refractory essential thrombocythemia.Design Methods conducted collaborative retrospective study across Europe. Our database...
The BCR-ABL T315I mutation confers resistance to currently licensed tyrosine kinase inhibitors in chronic myelogenous leukemia. However, the impact of this on survival early stages disease, phase, has never been detailed. Using matched pair analysis, a cohort 64 patients with phase leukemia harboring and resistant imatinib mesylate was compared similar 53 imatinib, but no detectable mutation, pre-ponatinib era. These were according age at diagnosis, interval between disease diagnosis start...
Abstract Among myeloproliferative neoplasms, polycythemia vera (PV) and essential thrombocythemia (ET) are the 2 entities associated with most chronic disease course. Leukemic evolution occurs rarely but has a grim prognosis. The interval between diagnosis leukemic is highly variable, from few years to >20 years. We performed molecular evaluation of 49 transformations PV ET by targeted next-generation sequencing. Using hierarchical classification, we identified 3 groups distinct time...
Background Many different techniques have been designed for the quantification of JAK2V617F allelic burden, sometimes producing discrepant results.Design and Methods were compared among 16 centers using 11 assays based on quantitative polymerase chain reaction (with mutation-specific primers or probes, fluorescent resonance energy transfer/melting curve analysis), allele-specific reaction, conventional sequencing pyrosequencing.Results A first series blinded samples (granulocyte DNA, n=29)...