Yosaku Watatani
A5054422598- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- RNA Research and Splicing
- Inflammatory Bowel Disease
- Cutaneous lymphoproliferative disorders research
- Retinoids in leukemia and cellular processes
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Eosinophilic Disorders and Syndromes
- RNA regulation and disease
- NF-κB Signaling Pathways
- CNS Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- T-cell and B-cell Immunology
Kyoto University
2015-2024
Kindai University Hospital
2020-2021
Kindai University
2015-2021
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion, being the most common entity in mature neoplasms, and its molecular pathogenesis remains significantly understudied. Here, combining whole-exome targeted-capture sequencing, gene-expression profiling, immunohistochemical analysis tumor samples from 133 cases, we have delineated entire landscape somatic alterations, discovered frequently affected driver pathways PTCL, NOS, with without T-follicular...
Spliceosome mutations are frequently found in myelodysplasia. Splicing alterations induced by these mutations, their precise targets, and the effect at transcript level have not been fully elucidated. Here we report transcriptomic analyses of 265 bone marrow samples from myelodysplasia patients, followed a validation using CRISPR/Cas9-mediated gene editing an assessment nonsense-mediated decay susceptibility. Small but widespread reduction intron-retaining isoforms is most frequent splicing...
Viral infection induces potent cellular immunity and activated intracellular signaling, which may dictate the driver events involved in immune escape clonal selection of virus-associated cancers, including Epstein-Barr virus (EBV)-positive lymphomas. Here, we thoroughly interrogated PD-L1/PD-L2-involving somatic aberrations 384 samples from various lymphoma subtypes using high-throughput sequencing, particularly focusing on A high frequency genetic was observed EBV-positive lymphomas [33...
Abstract Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role BC, the landscape and prognostic impact of these remain elusive. Here, we comprehensively investigate abnormalities 136 BC 148 phase (CP) samples obtained from 216 CML using exome targeted sequencing. One or more are found 126 (92.6%) out patients, including RUNX1 - ETS2 fusion NBEAL2 mutations. The number increase during transition...
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B,...
We previously examined the utility of rituximab-bendamustine (RB) in patients with follicular lymphoma (FL) exhibiting less than optimal responses to 2 cycles R-CHOP chemotherapy regimen. The aim this study was identify molecular biomarkers that can predict prognosis RB-treated context prospective cohort. first analyzed mutational status 410 genes diagnostic tumor specimens by target capture and Sanger sequencing. CREBBP, KMT2D, MEF2B, BCL2, EZH2, CARD11 were recurrently mutated as reported...
Summary Despite duodenal‐type follicular lymphoma (DTFL) being morphologically, immunophenotypically and genetically indistinguishable from nodal FL (nFL), this entity typically shows a significantly better prognosis. Here, we analysed the tumour immune microenvironments of diagnostic specimens patients with DTFL ( n = 30), limited‐stage (LSFL; 19) advanced‐stage (ASFL; 31). The mean number CD8 + tumour‐infiltrating lymphocytes (TILs) in neoplastic follicles was higher (1,827/mm 2 ) than...
We report a case with extramedullary tumors affecting the supraclavicular region that presented as relapse of acute myeloid leukemia (AML) FLT3-ITD mutation after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Treatment gilteritinib resulted in remarkable response disappearance both medullary and tumors. Subsequently, 2nd allo-HSCT was performed an attempt to cure his AML complete molecular has been sustained resumption without worsening GVHD. Targeted therapy for could be...
Telomere length is maintained by the activation of telomerase, which causes continuous cell division and proliferation in many carcinomas. A catalytic reverse transcriptase protein (TERT) encoded TERT gene plays a critical role telomerase. We performed molecular pathological analysis against three different peripheral T-cell lymphoma (PTCL) subtypes: PTCL, not otherwise specified (PTCL-NOS), angioimmunoblastic (AITL), adult leukemia/lymphoma (ATLL). Immunohistochemical demonstrated...
We recently treated a chronic myeloid leukemia (CML) patient with liver and renal dysfunction, who was undergoing hemodialysis (HD). He 50 mg dasatinib (DAS) once daily just before HD. The maximum plasma concentration of DAS 227 ng/mL on non-HD day 46.9 HD day. subsequently 200 bosutinib (BOS) daily. BOS changed from 74.5 to 58.8 after Our results indicate that close monitoring the tyrosine kinase inhibitor concentrations should be considered in CML patients organ impairment.
<div>Abstract<p>Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein–Barr virus (EBV)–related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously...
<div>Abstract<p>Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein–Barr virus (EBV)–related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously...
<p>Supplementary Figures S1-S10, Supplementary Table Legends</p>
<p>Supplementary Figures S1-S10, Supplementary Table Legends</p>