A5057836561- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Histiocytic Disorders and Treatments
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Cardiac tumors and thrombi
- RNA Research and Splicing
- Musculoskeletal synovial abnormalities and treatments
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Circular RNAs in diseases
Istituto Ortopedico Rizzoli
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Policlinico S.Orsola-Malpighi
2010-2021
University of Bologna
2010-2021
European Institute of Oncology
2017-2019
Istituto Oncologico Romagnolo
2011
Endemic Burkitt lymphoma (eBL) is primarily found in children equatorial regions and represents the first historical example of a virus-associated human malignancy. Although Epstein-Barr virus (EBV) infection MYC translocations are hallmarks disease, it unclear whether other factors may contribute to its development. We performed RNA-Seq on 20 eBL cases from Uganda showed that mutational viral landscape more complex than previously reported. First, we presence herpesviridae family members 8...
Purpose The differential diagnosis among the commonest peripheral T-cell lymphomas (PTCLs; ie, PTCL not otherwise specified [NOS], angioimmunoblastic lymphoma [AITL], and anaplastic large-cell [ALCL]) is difficult, with morphologic phenotypic features largely overlapping. We performed a phase III diagnostic accuracy study to test ability of gene expression profiles (GEPs; index test) identify subtype. Methods studied 244 PTCLs, including 158 PTCLs NOS, 63 AITLs, 23 ALK-negative ALCLs....
Significance Guanine nucleotide exchange factor VAV1 encodes an adaptor and signal transduction with important roles in T-cell receptor signaling. This study identifies activating recurrent mutations fusions peripheral lymphomas, directly establishing oncogenic role for constitutive signaling the pathogenesis of this disease.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy for which there still no effective therapy. In order to identify genetic alterations useful new treatment design, we used whole-exome sequencing analyze 14 BPDCN patients the patient-derived CAL-1 line. The functional enrichment analysis of mutational data reported epigenetic regulatory program be most significantly undermined (P
Peripheral T-cell lymphoma not otherwise specified represents a diagnostic category comprising clinically, histologically, and molecularly heterogeneous neoplasms that are poorly understood. The genetic landscape of peripheral remains largely undefined, only few sequencing studies having been conducted so far. In order to improve our understanding the genetics this neoplasm, we performed whole exome along with RNA-sequencing in discovery set 21 cases. According results mutations previously...
Background Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases and correlates with an adverse prognosis. Methods To understand the molecular bases aneuploid (A‐AML), this study examined genomic profile 42 A‐AML 35 euploid (E‐AML) cases. Results was characterized by increased complexity based on exonic variants (an average 26 somatic mutations per sample vs 15 for E‐AML). The integration exome, copy number, gene expression data revealed alterations genes involved DNA...
Long non-coding RNAs (lncRNAs) are ncRNAs more than 200 nucleotides long that participate to a wide range of biological functions. However, their role in cancer is poorly known. By using an NGS-based approach we analyzed the intragenic and poliA-lncRNAs hepatocellular carcinoma (HCC) assayed relationships between deregulated expression clinical-pathological characteristics. The profile lncRNAs was studied discovery series 28 HCC matched cirrhosis validated independent cohort 32 patients both...
Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding phenotype, molecular characteristics, histogenesis, possible mechanisms lymphomagenesis. There is complete consensus on B-cell derivation tumor in most cases, relevance Epstein-Barr virus infection defective cytokinesis at least proportion patients. The REAL/WHO classification recognizes basic distinction between...
// Pier Paolo Piccaluga 1 , Mohsen Navari 1, 2 Giulia De Falco 2, 3 Maria Raffaella Ambrosio Stefano Lazzi Fabio Fuligni Cristiana Bellan Maura Rossi Rosaria Sapienza Antonella Laginestra Maryam Etebari Emily A. Rogena 4 Lynnette Tumwine 5 Claudio Tripodo 6 Davide Gibellini 7 Jessica Consiglio 8 Carlo M. Croce Pileri 9 Lorenzo Leoncini Hematopathology Section, Department of Experimental, Diagnostic, and Experimental Medicine, S. Orsola-Malpighi Hospital, Bologna University School Bologna,...
Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) comprises heterogeneous lymphoid malignancies characterized by pleomorphic lymphocytes and variable inflammatory cell-rich tumor microenvironment. Genetic drivers in PTCL-NOS include genomic alterations affecting the VAV1 oncogene; however, their specific role mechanisms remain incompletely understood. Here we show that expression of Vav1-Myo1f, a recurrent PTCL-associated fusion, induces oncogenic transformation CD4
Epstein Barr virus (EBV) infection is commonly associated with human cancer and, in particular, lymphoid malignancies. Although the precise role of pathogenesis different lymphomas largely unknown, it well recognized that expression viral latent proteins and miRNA can contribute to its patoghenetic role. In this study, we compared gene profile two EBV-associated aggressive B non-Hodgkin known be characterized by differential aiming dissect possible contribution such EBV-encoded miRNAs. By...
Abstract Capicua-double homeobox 4 (CIC-DUX4)–rearranged sarcomas (CDS) are extremely rare, highly aggressive primary that represent a major therapeutic challenge. Patients treated according to Ewing sarcoma protocols, but CDS-specific therapies strongly needed. In this study, RNA sequencing was performed on patient samples identify selective signature differentiates CDS from and other fusion-driven sarcomas. This used validate the representativeness of newly generated experimental...
Peripheral T-cell lymphomas not otherwise specified (PTCLs/NOS) are rare and aggressive tumours whose molecular pathogenesis diagnosis still challenging. The microRNA (miRNA) profile of 23 PTCLs/NOS was generated compared with that normal T-lymphocytes (CD4+, CD8+, naive, activated). differentially expressed miRNA signature the gene expression (GEP) same neoplasms. obtained patterns were tested in an independent cohort PTCLs/NOS. then 10 angioimmunoblastic (AITLs), 6 anaplastic large-cell...
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors with variable clinical, morphologic, and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC compared other tumors, microdissected Castleman FDCs, normal fibroblasts. Using unsupervised analysis, clustered distinct from The specific endowment of FDC-related gene expression programs in emerged by applying a signature differentially expressed genes (n = 1,289) between FDCs Supervised comparing...
Pediatric acute myeloid leukemia (AML) is an aggressive malignancy with poor prognosis for which there are few effective targeted approaches, despite the numerous genetic alterations, including MLL gene rearrangements (MLL-r). The histone methyltransferase DOT1L involved in supporting proliferation of MLL-r cells, a target inhibitor, Pinometostat, has been evaluated clinical trial recruiting pediatric leukemic patients. However, modest effects have observed. Recent studies reported that...
The contribution of cell-extrinsic factors in Acute Myeloid Leukemia (AML) generation and persistence has gained interest. Bitter taste receptors (TAS2Rs) are G protein-coupled known for their primary role as a central warning signal to induce aversion toward noxious or harmful substances. Nevertheless, the increasing amount evidence about extra-oral localization suggested wider function sensing microenvironment, also cancer settings. In this study, we found that AML cells express functional...
Abstract A percentage of celiac disease (CD) patients develop refractory type-2 (RCD2), a condition associated with increased risk enteropathy-associated T-cell-lymphoma (EATL) and without therapeutic option. Therefore, we profiled the miRNome in series peripheral T-cell lymphomas (PTCLs), CD, RCD1 or 2 murine interleukin-15 (IL15)-transgenic (TG) model RCD. The transcriptome was analyzed 18 intestinal (ITLs). Bioinformatics pipelines provided significant microRNA (miRNA) lists predicted...
Abstract Ewing sarcoma (EWS) is a challenging pediatric cancer characterized by vast intra-tumor heterogeneity. We evaluated the RNA-binding protein IGF2BP3, whose high expression correlates with poor prognosis and an elevated tendency of metastases, as possible soluble mediator inter-cellular communication in EWS. Our data demonstrate that (i) IGF2BP3 detected cell supernatants, it released inside extracellular vesicles (EVs); (ii) EVs from IGF2BP3-positive or IGF2BP3-negative EWS cells...