A5081540419- Celiac Disease Research and Management
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Chronic Lymphocytic Leukemia Research
- Helicobacter pylori-related gastroenterology studies
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Gastrointestinal Tumor Research and Treatment
- Lymphatic Disorders and Treatments
- Appendicitis Diagnosis and Management
- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- Digestive system and related health
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- T-cell and Retrovirus Studies
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Intestinal and Peritoneal Adhesions
Université Paris Cité
2016-2025
Hôpital Cochin
2018-2025
Institut des Maladies Génétiques Imagine
2014-2024
Inserm
2015-2024
Délégation Paris 5
2012-2024
Sorbonne Paris Cité
2012-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Hôpital Européen Georges-Pompidou
2013-2024
Hôpital Européen
2012-2022
Descartes (Belgium)
2015-2019
OBJECTIVES: The enteropathy associated with common variable immunodeficiency (CVID) is poorly characterized, and its possible relationships well-defined causes of enteropathy, such as celiac sprue (CS), remain debated. We aimed to assess the clinical histopathological features CVID. METHODS: medical files 50 CVID patients gastrointestinal symptoms were analyzed retrospectively. Histological, phenotypic, molecular analysis intestinal endoscopic specimens was centrally performed. RESULTS:...
Background Recently, a new enteropathy has been described: olmesartan-associated enteropathy. However, the association questioned: phase 3 trial and cohort study found no between gastrointestinal events olmesartan. Aim To collect French cases of sartan-associated to describe further this entity, confirm or refute causality, determine if exists with other sartans. Methods gastroenterologists were invited report clinical, biological histological data. Patients diarrhoea duodenal abnormalities...
Celiac disease (CD) is an enteropathy resulting from abnormal immune response to gluten-derived peptides in genetically susceptible individuals. This initiated by intestinal transport of intact peptide 31-49 (p31-49) and 33-mer gliadin through unknown mechanism. We show that the transferrin receptor CD71 responsible for apical basal retrotranscytosis peptides, a process during which p31-49 are protected degradation. In patients with active CD, overexpressed epithelium colocalizes...
Enteropathy-associated T cell lymphoma is a severe complication of celiac disease (CD). One mechanism suggested to underlie its development chronic exposure intraepithelial lymphocytes (IELs) potent antiapoptotic signals initiated by IL-15, cytokine overexpressed in the enterocytes individuals with CD. However, signaling pathway which IL-15 transmits these has not been firmly established. Here we show that survival delivered freshly isolated human IELs and IEL lines derived from CD patients...
Prognosis of enteropathy-associated T cell lymphoma is poor but predictors survival remain ill-defined. How clinical presentation, pathological features and therapies influence outcome was evaluated in 37 thoroughly characterized patients with celiac disease T-cell lymphoma.Medical files were studied retrospectively. Lymphoma intestinal mucosa analysed by histopathology, multiplex PCR intraepithelial lymphocytes phenotyping. Survival prognostic factors using Kaplan-Meier curves Logrank test...
Summary Background The risk of urinary tract cancers, including kidney and bladder was increased in transplant recipients receiving thiopurines. Aim To assess the cancers patients with inflammatory bowel disease ( IBD ) thiopurines CESAME observational cohort. Methods Between May 2004 June 2005, 19 486 , 30.1% whom were thiopurines, enrolled. Median follow‐up 35 months IQR : 29–40). Results Ten six developed respectively cancer. incidence rates cancer 0.48/1000 patient‐years (95% CI...
Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of coeliac disease (CeD), often preceded by low-grade clonal intraepithelial lymphoproliferation, referred to as type II refractory CeD (RCDII). Knowledge on underlying oncogenic mechanisms remains scarce. Here, we analysed and compared the mutational landscape RCDII EATL in order identify genetic drivers CeD-associated lymphomagenesis.Pure populations RCDII-cells derived from intestinal biopsies (n=9) or sorted...
Due to the potential role of gut microbiota and bile acids in pathogenesis both inflammatory bowel disease (IBD) sporadic colorectal cancer, we aimed determine whether these factors were associated with cancer IBD patients. 215 patients 51 non-IBD control subjects enrolled from 10 French centers between September 2011 July 2018. Fecal samples processed for bacterial 16S rRNA gene sequencing acid profiling. Demographic, clinical, endoscopic, histological outcomes recorded. Characteristics...
Non-responsive celiac disease (NRCD) is relatively common. It generally attributed to persistent gluten exposure and resolves after correction of diet errors. However, other complications CD disorders clinically mimicking CD, need be excluded. Novel therapies are being evaluated facilitate mucosal recovery, which might benefit NRCD patients. Refractory (RCD) rare currently divided into two types. The etiology RCD type 1 (RCDI) unclear, a possible switch gluten-independent autoimmunity...
Whether a life-long gluten-free diet (GFD) is necessary in all children with diagnosed coeliac disease (CD) remains debated. To address this question, retrospective analysis of the clinical and biological status adult patients childhood, who remained on normal after gluten challenge were clinically silent, was carried out.Patients aged 18-65 years CD childhood included. Clinical status, intake, parameters malabsorption, bone mineral density, human leucocyte antigen (HLA) genotype,...
Early rebleeding rate after endoscopic therapy with double balloon enteroscopy (DBE) of hemorrhagic small bowel vascular lesions (SBVL) varies between 10 and 50%. In recent reports, long-term follow-up patients have been described but risk factors are still not well established. The aim the current study was to identify treatment success DBE in a large cohort.We conducted single-center, retrospective cohort French tertiary-referral center January 2004 December 2007.Among 261 presenting...
OBJECTIVES: Capsule endoscopy (CE) allows for the assessment of small bowel in numerous intestinal diseases, including celiac disease (CD). The main advantage CE is complete visualization mucosal surface. objective this study was to investigate whether can predict severity CD and detect complications. METHODS: We retrospectively studied medical files 9 patients with symptomatic CD, 11 refractory type I (RCDI) 18 II (RCDII), 45 without who were investigated both upper or enteroscopy....
An expanding number of monogenic defects have been identified as causative severe forms very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification known molecular diagnosis and adapt treatment.A total 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation VEO-IBD [n = 185]...