A5010960233- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Congenital gastrointestinal and neural anomalies
- Vagus Nerve Stimulation Research
- Single-cell and spatial transcriptomics
- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Pluripotent Stem Cells Research
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Whipple's Disease and Interleukins
- Diabetes and associated disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal Respiratory Health Research
Champalimaud Foundation
2016-2025
Taylor's University
2018
Tufts University
2018
Jean Mayer Human Nutrition Research Center on Aging
2018
University of Miami
2018
Instituto de Medicina Molecular João Lobo Antunes
2009-2017
Hospital de Egas Moniz
2010-2017
University of Lisbon
2011-2017
Institute of Molecular Medicine
2014
National Legal Medicine Institute
2012
Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which sensed what receptors control ILC3 function remain poorly understood. Here, we show that ILC3s with a lymphoid-tissue-inducer (LTi) phenotype expressed G-protein-coupled receptor 183 (GPR183) migrated to its oxysterol ligand 7α,25-hydroxycholesterol (7α,25-OHC). In mice lacking Gpr183 or 7α,25-OHC, failed localize cryptopatches (CPs) isolated follicles (ILFs)....
The immune system shapes body metabolism, while interactions between peripheral neurons and cells control tissue homeostasis immunity. However, whether neuroimmune orchestrate endocrine functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the pancreas, which was dependent on their expression of...
Abstract Neural crest (NC)-derived mesenchyme has previously been shown to play an important role in the development of fetal thymus. Using Wnt1-Cre and Sox10-Cre mice crossed Rosa26eYfp reporter mice, we have revealed NC-derived mesenchymal cells adult murine We report that infiltrate thymus before day 13.5 embryonic (E13.5) differentiate into with characteristics smooth muscle associated large vessels, pericytes capillaries. In organ at 3 mo age, these perivascular continue be vasculature,...
et à la diffusion de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement recherche français étrangers, laboratoires publics privés.
Interactions between immune and neuronal cells are pillars in tissue homeostasis
Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits promote tissue health homeostasis. Immunoglobulin A (IgA) directly determine composition species colonize intestinal tract but require substantial resources to fuel antibody production by tissue-resident plasma cells. Here, we demonstrate IgA subject diurnal regulation over course circadian day. Specifically, magnitude secretion, as well...
CD4 T cell help was proposed to have a pivotal role in orienting CD8 responses antigen stimulation. By activating antigen-presenting cells (APC), would induce their expression of costimulatory molecules, the "signal two" required full activation, preventing tolerance. Recent data on this subject is contradictory, as absence did not alwaysresult These differences were attributed either presence residual or, respectively type stimulation, peptide affinity, CTL frequencies, and/or strength...