A5022212836- IL-33, ST2, and ILC Pathways
- thermodynamics and calorimetric analyses
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Microbial Metabolic Engineering and Bioproduction
- Chemical and Physical Properties in Aqueous Solutions
- Chemical Thermodynamics and Molecular Structure
- Circadian rhythm and melatonin
- Enzyme Catalysis and Immobilization
- Health, psychology, and well-being
- Helicobacter pylori-related gastroenterology studies
- Viral Infectious Diseases and Gene Expression in Insects
- Gut microbiota and health
- T-cell and B-cell Immunology
- Dietary Effects on Health
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- biodegradable polymer synthesis and properties
Champalimaud Foundation
2019-2025
University of Lisbon
2016-2017
The immune system shapes body metabolism, while interactions between peripheral neurons and cells control tissue homeostasis immunity. However, whether neuroimmune orchestrate endocrine functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the pancreas, which was dependent on their expression of...
Interactions between the mammalian host and commensal microbiota are enforced through a range of immune responses that confer metabolic benefits promote tissue health homeostasis. Immunoglobulin A (IgA) directly determine composition species colonize intestinal tract but require substantial resources to fuel antibody production by tissue-resident plasma cells. Here, we demonstrate IgA subject diurnal regulation over course circadian day. Specifically, magnitude secretion, as well...
The circadian rhythm of the immune system helps to protect against pathogens1–3; however, role rhythms in homeostasis is less well understood. Innate T cells are tissue-resident lymphocytes with key roles tissue homeostasis4–7. Here we use single-cell RNA sequencing, a molecular-clock reporter and genetic manipulations show that innate IL-17-producing cells—including γδ cells, invariant natural killer mucosal-associated cells—are enriched for genes compared their IFNγ-producing counterparts....
Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation, infection, microbiota composition and metabolism 1 . ILC3 neuronal were shown to interact at discrete mucosal locations steer defence 2,3 Nevertheless, whether neuroimmune circuits operate an organismal level, integrating extrinsic environmental signals orchestrate responses remains elusive. Here we show that light-entrained brain-tuned circadian regulate enteric ILC3, intestinal homeostasis, gut the host lipid...
ABSTRACT Mutualistic interactions with the commensal microbiota are enforced through a range of immune responses that confer metabolic benefits for host and ensure tissue health homeostasis. Immunoglobulin (Ig)A directly determine composition species colonize intestinal tract but require significant resources to fuel antibody production by tissue-resident plasma cells. Here we demonstrate IgA subject diurnal regulation dietary-derived cues cell-intrinsic circadian clock. Rhythmicity in...
SUMMARY Metabolic alterations have been recognized to underly the etiology of many diseases. Herein, cellular energy dissipation was evaluated as a novel non-specific global biomarker metabolic alterations. Energy dissipation, measured heat by microcalorimetry, maximal during Saccharomyces cerevisiae adaptation growth conditions before fast proliferation took place. This response further augmented 95 % in media where nutrient assimilation more difficult, and 133 under sub-optimal non-carbon...