A5023697688- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Helicobacter pylori-related gastroenterology studies
- Diet, Metabolism, and Disease
- Eosinophilic Esophagitis
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- IL-33, ST2, and ILC Pathways
- Mitochondrial Function and Pathology
University Children's Hospital Zurich
2022-2025
University of Zurich
2022-2025
The immune system shapes body metabolism, while interactions between peripheral neurons and cells control tissue homeostasis immunity. However, whether neuroimmune orchestrate endocrine functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the pancreas, which was dependent on their expression of...
Nutrition during critical developmental windows plays a pivotal role in shaping long-term metabolic health. Exposure to Western diet early life may lead altered programing, potentially influencing the risk develop obesity and type 2 diabetes. In particular, an exposure obesogenic induce program that only emerges upon dietary challenges later life. Accordingly, understanding impact of nutritional insults different stages provide strategies for primary prevention. Therefore, present study...
<title>Abstract</title> Viral infection makes us feel sick. The extent of these changes to our metabolism are relative the severity disease. Whether blood glucose levels subject infection-induced modulation is largely unknown. Here we show that strong, non-lethal restricts systemic availability which promotes antiviral IFN-I response. Following viral mice, find IFNγ produced by γδ T cells directly stimulates pancreatic β-cells increase glucose-induced insulin release. Subsequently,...
<title>Abstract</title> Upon high-fat diet (HFD) feeding, excessive amounts of saturated long-chain fatty acids (LCFAs) flood the brain via unknown mechanisms and induce a state “lipotoxicity”, promoting overfeeding obesity. Here we demonstrate that astrocytes actively control LCFA shuttling cluster differentiation (CD)36. We found HFD feeding induces CD36 expression in glial fibrillary acidic protein (GFAP)-expressing hypothalamic astrocytes, which allows for increased uptake. Brain...
Abstract Activation of Fas (CD95) in adipocytes inhibits browning and may contribute to body weight gain mice. Moreover, expression white adipose tissue (WAT) correlates positively with mass index (BMI) humans. However, molecular pathways involved the inhibitory effect on energy metabolism remain incompletely understood. Herein, we report that protein levels tumor suppressor p53 were reduced primary adipocyte-specific Fas-knockout ligand (FasL) treatment increased concentrations cultured...
Abstract Background Deoxyguanosine kinase (DGUOK) deficiency is one of the genetic causes mitochondrial DNA depletion syndrome (MDDS) in humans, leading to hepatocerebral or isolated hepatic form MDDS. Mouse models are helpful tools for improvement understanding pathophysiology diseases and offer opportunity examine new therapeutic options. Methods Herein, we describe generation metabolic characterization a mouse line carrying homozygous Dguok F180S/F180S mutation derived from an N -ethyl-...