A5006028451- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Chemical Reactions and Isotopes
- Asymmetric Hydrogenation and Catalysis
- Celiac Disease Research and Management
- Cell Adhesion Molecules Research
- Radiopharmaceutical Chemistry and Applications
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Biochemical and Structural Characterization
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Synthetic Organic Chemistry Methods
- Sulfur-Based Synthesis Techniques
- Quantum, superfluid, helium dynamics
- S100 Proteins and Annexins
- Click Chemistry and Applications
- Enzyme Catalysis and Immobilization
- Ferrocene Chemistry and Applications
Université Paris-Saclay
2017-2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2009-2022
CEA Paris-Saclay
2008-2022
Laboratoire de Chimie Organique
1998-2019
Institut de Biologie et Technologies
2008-2016
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique
2014
Technologies pour la Santé
2013
Laboratoire Structure et Dynamique par Résonance Magnétique
2013
Service Interdisciplinaire sur les Systèmes Moléculaires et les Matériaux
2013
In-Q-Tel
2012
Celiac disease (CD) is an enteropathy resulting from abnormal immune response to gluten-derived peptides in genetically susceptible individuals. This initiated by intestinal transport of intact peptide 31-49 (p31-49) and 33-mer gliadin through unknown mechanism. We show that the transferrin receptor CD71 responsible for apical basal retrotranscytosis peptides, a process during which p31-49 are protected degradation. In patients with active CD, overexpressed epithelium colocalizes...
Neutrophils express the G protein-coupled N-formyl peptide receptor (FPR) and its homologue FPRL1, whereas monocytes FPR, FPRL2, an orphan sharing 83% amino acid identity with FPRL1. FPRL1 is a promiscuous activated by serum amyloid A different synthetic peptides, including hexapeptide Trp-Lys-Tyr-Met-Val-d-Met-NH2 (WKYMVm). By measuring calcium flux in HL-60 cells transfected or we show that WKYMVm all three receptors, thel-conformer WKYMVM exclusively FPRL2. The functionality of FPRL2 was...
The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, catalytic activity remains unknown. Here, we show that cyclodipeptide cyclo(l-Tyr-l-Tyr) (cYY) binds to CYP121, and efficiently converted into a single major product in assay containing spinach ferredoxin reductase. NMR spectroscopy analysis of reaction shows catalyzes formation an intramolecular C-C bond between 2 tyrosyl carbon atoms cYY resulting novel chemical entity. X-ray structure...
Abstract An efficient H/D exchange method allowing the deuteration of pyridines, quinolines, indoles, and alkyl amines with D 2 in presence Ru@PVP nanoparticles is described. By a general simple procedure involving mild reaction conditions filtration to recover labeled product, isotopic labeling 22 compounds proceeded good yield high chemo‐ regioselectivity. The viability this was demonstrated by eight biologically active compounds. Remarkably, enantiomeric purity conserved compounds, even...
The activation of C-H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific been developed to date. We herein report an reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity α-position directing heteroatom results from a four-membered dimetallacycle as key intermediate. This work paves way novel molecular chemistry on nanoparticles.
The preparation of N-heterocyclic carbene-stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air-stable easy-to-handle showed a unique catalytic activity, allowing selective efficient incorporation on anilines using D2 or T2 as isotopic source. usefulness this transformation has been demonstrated by the deuterium tritium labeling diverse complex pharmaceuticals.
Sialorphin is an exocrine and endocrine signaling mediator, which has been identified by a genomic approach. It synthesized predominantly in the submandibular gland prostate of adult rats response to androgen steroids released locally systemically stress. We now demonstrate that cell surface molecule sialorphin binds vivo rat kidney membrane-anchored neutral endopeptidase (neprilysin; NEP, EC 3.4.24.11). NEP plays important role nervous peripheral tissues, as it turns off several...
Tryptophan metabolism through the kynurenine pathway leads to several neuroactive compounds, including kynurenic and picolinic acids. Xanthurenic acid (Xa) has been generally considered as a substance with no physiological role but possessing toxic apoptotic properties. In present work, we findings which support for endogenous Xa in synaptic signalling brain. This is micromolar amounts most regions of rat brain heterogeneous distribution. An active vesicular process inhibited by bafilomycin...
The synthesis of bioinspired unnatural backbones leading to foldamers can provide effective peptide mimics with improved properties in a physiological environment. This approach has been applied the design structural membrane active antimicrobial peptides (AMPs) for which activities vitro have reported. Yet and pharmacokinetic vivo animal models remained largely unexplored. Here, we report helical oligourea AMP that are against bacterial forms Bacillus anthracis encountered vivo, as well...
Abstract An efficient H/D exchange method allowing the deuteration of pyridines, quinolines, indoles, and alkyl amines with D 2 in presence Ru@PVP nanoparticles is described. By a general simple procedure involving mild reaction conditions filtration to recover labeled product, isotopic labeling 22 compounds proceeded good yield high chemo‐ regioselectivity. The viability this was demonstrated by eight biologically active compounds. Remarkably, enantiomeric purity conserved compounds, even...
Abstract The activation of CH bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific been developed to date. We herein report an reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity α‐position directing heteroatom results from a four‐membered dimetallacycle as key intermediate. This work paves way novel molecular chemistry on nanoparticles.
ACS Paragon Plus EnvironmentThe Journal of Organic Chemistry 2 A visible-light mediated late-stage aminocarbonylation unactivated alkyl iodides with stoichiometric amount carbon monoxide is presented.The method provides a mild, one-step route to [carbonyl-13/14 C]alkyl amides; thereby, reducing radioactive waste, and handling material.Easily accessible low cost equipment palladium catalyst were successfully used for the synthesis wide range amides.
Abstract Gaining an understanding of the nature host–guest interactions in supramolecular complexes involving heavy atoms is a difficult task. Described herein robust simulation method applied to between xenon and members cryptophane family. The calculated chemical shift caged H 2 O probe, as modeled by quantum chemistry with complementary‐orbital, topological, energy‐decomposition analyses, excellent agreement that observed hyperpolarized 129 Xe NMR spectra. This approach can be extended...
Abstract The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air‐stable easy‐to‐handle showed a unique catalytic activity, allowing selective efficient incorporation on anilines using D 2 or T as isotopic source. usefulness this transformation has been demonstrated by the deuterium tritium labeling diverse complex pharmaceuticals.
The development of optimized xenon host systems is crucial importance for the success molecular imaging using hyperpolarized 129Xe MRI. Cryptophane-111 a promising candidate because its encapsulation properties. synthesis cryptophane-111-based biosensors requires both water-solubilizing and chemically activatable groups. An expeditious water-soluble functionalizable cryptophane-111 described.