A5076315023- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Quantum, superfluid, helium dynamics
- NMR spectroscopy and applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced MRI Techniques and Applications
- Supramolecular Chemistry and Complexes
- Electron Spin Resonance Studies
- Molecular spectroscopy and chirality
- Molecular Sensors and Ion Detection
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- Solid-state spectroscopy and crystallography
- Spectroscopy and Quantum Chemical Studies
- Mass Spectrometry Techniques and Applications
- Radioactive element chemistry and processing
- Chemical Synthesis and Characterization
- Analytical Chemistry and Chromatography
- Carbohydrate Chemistry and Synthesis
- Enzyme Structure and Function
- Mechanical and Optical Resonators
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Chemical Synthesis and Analysis
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2015-2024
Centre National de la Recherche Scientifique
2015-2024
CEA Paris-Saclay
2015-2024
Université Paris-Saclay
2016-2024
Laboratoire Structure et Dynamique par Résonance Magnétique
2009-2022
Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Énergie
2021-2022
CEA Paris-Saclay - Etablissement de Saclay
1991-2017
Université Paris Cité
2017
Institut Rayonnement-Matière de Saclay
2008-2015
California Earthquake Authority
2015
Hierarchically nested hosts offer new opportunities to control the guest binding of inner host, functionalize cavity outer and investigate communication between different layers. Here we report a self-assembled triazatruxene-based FeII4L4 capsule, which was able encapsulate covalent cage, cryptophane-111 (CRY). The resulting cage-in-cage complex capable accommodating cesium cation or xenon atom with altered behavior compared CRY alone. A crystal structure Russian doll [Cs+⊂CRY]⊂FeII4L4...
Cryptophanes bearing OCH2COOH groups in place of the methoxy represent a new class xenon-carrier molecules soluble water at biological pH. By using 1H and 129Xe NMR (thermally- laser-polarized dissolved gas), structural dynamical behaviors these host as well their interaction with xenon are studied. They shown to exist aqueous solution under different conformations very slow exchange. A saddle form present for one could explain spectra. Whereas cryptophanes such conformation unable complex...
The smallest cryptophane ever synthesized, cryptophane-1.1.1 (1), whose internal volume is estimated to be 81 Å3, exhibits the highest binding constant (10000 M-1 at 293 K) in organic solution for xenon encapsulation determined date. very slow kinetics of decomplexation on NMR time scale results an extremely sharp 129Xe signal Xe@1 complex, which shows unexpected low-frequency shift. free energy activation K ΔG⧧out = 64.9 ± 3 kJ mol-1 (ΔH⧧out 43.2 1.6 mol-1; ΔS⧧out −74 J K-1). These...
Xenon capsule: A smart 129Xe NMR-based sensor of Zn2+ ions for magnetic resonance imaging (MRI) is proposed. The frequency xenon encapsulated in a cryptophane that bears nitrilotriacetic ligand moiety varies when are present solution (see picture). With hyper-polarized gas, such construct enables detection 100 nM zinc one batch, threshold 300 times lower than achieved with gadolinium chelates.
Abstract Signal amplification by reversible exchange (SABRE) is a promising method to increase the sensitivity of nuclear magnetic resonance (NMR) experiments. However, SABRE‐enhanced 1 H NMR signals are short lived, and SABRE often used record 1D spectra only. When sample interest complex mixture, this results in severe overlaps for spectra. In addition, use co‐substrate, whose may obscure spectra, currently most efficient way lower detection limit Here, we describe an approach obtain...
DNA sensor: A xenon host composed of a cryptophane structure with strand (see picture) serves to detect its complementary in the micromolar range through laser-polarized 129Xe NMR spectroscopy. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2267/2007/z700384_s.pdf or from author. Please note: The publisher not responsible content functionality any supporting supplied by authors. Any queries (other than missing content) should be directed...
The known xenon-binding (±)-cryptophane-111 (1) has been functionalized with six [(η(5)-C(5)Me(5))Ru(II)](+) ([Cp*Ru](+)) moieties to give, in 89% yield, the first water-soluble cryptophane-111 derivative, namely [(Cp*Ru)(6)1]Cl(6) ([2]Cl(6)). [2]Cl(6) exhibits a very high affinity for xenon water, binding constant of 2.9(2) × 10(4) M(-1) as measured by hyperpolarized (129)Xe NMR spectroscopy. chemical shift aqueous Xe@[2](6+) species (308 ppm) resonates over 275 ppm downfield parent Xe@1...
Nanofabrication by molecular self-assembly involves the design of molecules and strategies so that shape chemical complementarities drive units to organize spontaneously into desired structures. The power makes it ubiquitous strategy living organized matter provides a powerful tool chemists. However, challenging issue in complex supramolecular structures is understand how kinetically efficient pathways emerge from multitude possible transition states routes. Unfortunately, very few systems...
An approach for sensitive magnetic resonance detection of metal cations is proposed. Combining the use hyperpolarized 129Xe NMR and a cage-molecule functionalized by ligand able to chelate different cations, we show that simultaneous lead, zinc, cadmium ions at nanomolar concentration possible in short time, thanks fast MRI sequences based on HyperCEST scheme.
When working with hyperpolarized species, it is often difficult to maintain a stable level of magnetization over consecutive experiments, which renders their detection at the trace cumbersome, even when combined chemical exchange saturation transfer (CEST). We report herein use ultrafast Z-spectroscopy as powerful means detect low concentrations 129Xe NMR-based sensors and measure in–out xenon exchange. Modifications original sequence enable multiplexed several sensors, well extraction...
A recyclable Pt-carbon nanotube hybrid was developed for the hydrosilylation of a variety substrates under environmentally friendly conditions (no solvent, room temperature, low catalyst loading, air atmosphere).
Using soft-pulse 2D NMR techniques, nearly complete assignments of the 600 and 800 MHz spectra an octamethylene-spaced β-cyclodextrin (CD) homodimer (1, L=(CH2)8) a heterodimer with one α- β-CD can be made. These clearly show self-inclusion aliphatic spacer in CD units. When, for example, short ethylene is used to connect CDs, this self-encapsulation not occur. This difference behavior markedly affects binding properties different dimers. L=(CH2)2,(CH2)8,2,2′-bipyridyl.
The interaction of xenon with cryptophane derivatives is analyzed by NMR using either thermal or hyperpolarized noble gas. Twelve hosts differing their stereochemistry, cavity size, and the nature number substituents on aromatic rings have been included in study, aim extracting some clues for optimization (129)Xe-NMR based biosensors derived from these cage molecules. Four important properties examined: xenon-host binding constant, in-out exchange rate gas, chemical shift, relaxation caged...
Abstract In the 129 Xe NMR‐based biosensing approach in which hyperpolarized noble gas is transported to biological receptors for a sensitive molecular imaging, cryptophanes are excellent xenon host systems. However avoid formation of self‐organized systems, these hydrophobic cage molecules can be rendered water soluble by introduction ionic groups. We show that sensitivity its local environment and presence functions lead interesting properties. For first water‐soluble cryptophane...
Dissolution of hyperpolarized species in liquids interest for NMR is often hampered by the presence bubbles that degrade field homogeneity. Here a device composed bubble pump and miniaturized cell both fitted inside narrow bore an magnet built 3D printing. (129)Xe experiments performed with xenon reveal high homogeneous dissolution gas water.
Nonspecific lipid transfer protein from wheat is studied by liquid-state NMR in the presence of xenon. The gas-protein interaction indicated dependence proton chemical shifts on xenon pressure and formally confirmed first observation magnetization laser-polarized to protons. Twenty-six heteronuclear nOes have allowed characterization four sites inside ns-LTP cavity. Their locations are agreement with variations under solvation simulations. richness information obtained noble gas a nuclear...
129Xe MRI is applied to cage molecules in which hyperpolarized xenon exhibits a specific spectral signature. In few tens of seconds net spatial discrimination achieved between two different hosts dissolved immiscible media at submillimolar concentrations by using gradient echo sequence with interleaved frequency selection. This high sensitivity afforded not only the state but also continuous in-out exchange that enables replenishment detected signal. Moreover this direct approach,...