A5026083660- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- Chemical Reactions and Isotopes
- X-ray Diffraction in Crystallography
- Fluorine in Organic Chemistry
- Synthesis and Catalytic Reactions
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Cyclopropane Reaction Mechanisms
- Radioactive element chemistry and processing
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods
- Carbon dioxide utilization in catalysis
- Synthesis and Biological Evaluation
- Catalytic Cross-Coupling Reactions
- Radiopharmaceutical Chemistry and Applications
- Analytical Chemistry and Chromatography
- Asymmetric Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Ammonia Synthesis and Nitrogen Reduction
- Amino Acid Enzymes and Metabolism
- Analytical chemistry methods development
Université Paris-Saclay
2016-2025
Technologies pour la Santé
2018-2025
CEA Paris-Saclay
2016-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Unité de Technologies Chimiques et Biologiques pour la Santé
2021-2024
Institut de Biologie et Technologies
2009-2023
CEA Paris-Saclay - Etablissement de Saclay
2007-2023
Laboratoire de Chimie Organique
2014-2023
New Jersey Institute of Technology
2021
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets graphene in 2004 due to specific and versatile properties these materials. However, increasing production use 2D necessitate a thorough evaluation potential impact on human health environment. Furthermore, harmonized test protocols are needed with which assess safety The Graphene Flagship project (2013-2023), funded by European Commission, addressed identification possible...
Clean and green: Copper(I) complexes of phenanthroline-based ligands anchored on the chitosan polymer are good catalysts for "click" cycloaddition azides with terminal alkynes (see scheme; scanning electron microscopy image shows porous structure catalyst). These heterogeneous catalytic systems do not require a base or reducing agent operate in alcohol water.
Previous in vivo observations rats have shown that poly(ethylene glycol) polyhexadecylcyanoacrylate (PEG-PHDCA) nanoparticles could translocate into the brain after intravenous injection, which (PHDCA) did not. Through detailed analysis of plasma protein adsorption onto surface PEG-PHDCA nanoparticles, present study aimed at clarifying mechanism by penetrate rat endothelial cells (RBEC). Two-dimensional polyacrylamide gel electrophoresis and Western blotting revealed that, incubation with...
An immunoassay-based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability undergo chemoselective biocompatible [3+2] cycloaddition reactions. The approach fulfills most the requirements click concept led discovery a copper-catalyzed reaction that generates pyrazoles from sydnone alkyne reagents.
Abstract The concept of chelation‐assisted copper catalysis was employed for the development new azides that display unprecedented reactivity in copper(I)‐catalyzed azide–alkyne [3+2] cycloaddition (CuAAC) reaction. Azides bear strong copper‐chelating moieties were synthesized; these functional groups allow formation azide complexes react almost instantaneously with alkynes under diluted conditions. Efficient ligation occurred at low concentration and complex media only one equivalent...
This work describes the preparation and characterization of a library alginate-supported palladium nanoparticles together with their catalytic capabilities to promote Suzuki–Miyaura reaction. Using chelating properties carboxylate functions alginate matrix series Ca, Ba, Mn, Zn, Ni, Ce, Cu, Co gels were first prepared then reacted Pd2+ salts. Partial exchange metal cations followed by Pd reduction into supercritical CO2 drying generated panel bimetallic aerogels. Physical characterizations...
Abstract We report the discovery of a new bioorthogonal click‐and‐release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from ligation fragmentation under physiological conditions. Optimized were successfully used design innovative cleavable linkers for protein modification, thus opening up areas in fields drug release target‐fishing applications. technology offers possibility exchanging tags on proteins functionalized cyclooctynes mild
Iridium dimer complexes were found to catalyze the [3 + 2] cycloaddition reaction of azides with bromoalkynes, yielding 1,5-disubstituted 4-bromo-1,2,3-triazoles in reasonable excellent yields under mild conditions. The offers a direct route new 1,4,5-trisubstituted triazoles.
Abstract We report the synthesis and reactivity of 4‐fluorosydnones, a unique class mesoionic dipoles displaying exquisite towards both copper‐catalyzed strain‐promoted cycloaddition reactions with alkynes. Synthetic access to these new compounds was granted by electrophilic fluorination σ‐sydnone Pd II precursors in presence Selectfluor. Their terminal cyclic alkynes were found proceed very rapidly selectively, affording 5‐fluoro‐1,4‐pyrazoles bimolecular rate constants up 10 4 m −1 s ,...
The need for carbon-labeled radiotracers is increasingly higher in drug discovery and development (carbon-14, β-, t1/2 = 5730 years) as well positron emission tomography (PET) vivo molecular imaging applications (carbon-11, β+, 20.4 min). However, the structural diversity of still systematically driven by narrow available labeled sources methodologies. In this context, emergence carbon dioxide radical anion chemistry might set forth potential unexplored opportunities. Based on a dynamic...
More than 1000 yields and ee determinations are possible per day using an immunoassay. This highly efficient screening method is based on the remarkable binding specificity of antibodies. It has been employed in development straightforward procedures for direct conversion α-keto acids into chiral α-hydroxy acids, which enantioselective reduction benzoyl formic acid to mandelic serves as a model reaction (see scheme). Supporting information this article available WWW under...
Abstract The biodistribution of colloidal carriers after their administration in vivo depends on the adsorption some plasma proteins and apolipoproteins surface. Poly(methoxypolyethyleneglycol cyanoacrylate‐ co ‐hexadecylcyanoacrylate) (PEG‐PHDCA) nanoparticles have demonstrated capacity to cross blood–brain barrier (BBB) by a mechanism endocytosis. In order clarify this at molecular level, especially adsorbed surface PEG‐PHDCA were analyzed complementary methods such as CE Protein...
Few approaches are available to investigate the potential of carbon nanotubes (CNTs) translocate distant organs following lung exposure, although this needs be taken into account evaluate CNT toxicity. Here, we report a method for quantitative analysis tissue biodistribution multiwalled CNTs (MWCNTs) as function time. The relies on use in situ 14C-radiolabeled MWCNTs and combines radioimaging organ sections ex vivo by electron microscopy. To illustrate usefulness approach, mice were exposed...
4-Halogeno-sydnones were found to be efficient dipole partners for the strain promoted click reaction with bicyclo-[6.1.0]-nonyne. This bioorthogonal has been applied protein labeling.
Xenon capsule: A smart 129Xe NMR-based sensor of Zn2+ ions for magnetic resonance imaging (MRI) is proposed. The frequency xenon encapsulated in a cryptophane that bears nitrilotriacetic ligand moiety varies when are present solution (see picture). With hyper-polarized gas, such construct enables detection 100 nM zinc one batch, threshold 300 times lower than achieved with gadolinium chelates.
A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone–alkyne cycloaddition reaction. The procedure offers a straightforward and general route to pyrazole heterocycle through three-step one-pot procedure.
A bioorthogonal approach is explored to release the content of nanoparticles on demand. Exploiting our recently described click-and-release technology, we developed a new generation cleavable micelles able disassemble through sequential enzymatic and activation process. Proof-of-concept experiments showed that this could be successfully used deliver substances encapsulated into in living cells as well mice by two complementary targeted strategies.
A transition-metal-free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO
A photocatalytic approach for carbon isotope exchange is reported. Utilizing [13C]CO2 and [14C]CO2 as primary C1 sources, this protocol allows the insertion of desired into phenyl acetic acids without need structural modifications or prefunctionalization in one single step. The exceptionally mild conditions required traceless transformation are stark contrast with those previous methods requiring use harsh thermal conditions.