A5074222326- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Diatoms and Algae Research
- Photonic and Optical Devices
- Polydiacetylene-based materials and applications
- Proteins in Food Systems
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Spectroscopy and Quantum Chemical Studies
- Pickering emulsions and particle stabilization
- Surfactants and Colloidal Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Inorganic Chemistry and Materials
- Crystallization and Solubility Studies
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Photonic Crystals and Applications
- Glycosylation and Glycoproteins Research
- Porphyrin and Phthalocyanine Chemistry
- Food Chemistry and Fat Analysis
- Semiconductor Lasers and Optical Devices
- Organometallic Complex Synthesis and Catalysis
- nanoparticles nucleation surface interactions
- Advanced Fiber Optic Sensors
Institut de Physique de Rennes
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Université de Rennes
2016-2025
Université Rennes 2
2018-2021
Ministère de l'Intérieur
2018
Institut de Physique
2015
Université Européenne de Bretagne
2009-2014
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2003-2010
CEA Paris-Saclay
2010
Biophy Research (France)
2008-2009
The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report simple alternative method based on self-assembling nanotubes formed synthetic therapeutic octapeptide, Lanreotide in water. We used multidisciplinary approach involving optical and electron microscopies,...
Amphiphile supramolecular assemblies result from the cooperative effects of multiple weak interactions between a large number subcomponents. As result, prediction and control over morphologies such remains difficult to achieve. Here, we described fine-tuning shape, size, morphology transitions twisted helical membranes formed by non-chiral dicationic n-2-n gemini amphiphiles complexed with chiral tartrate anions. We have reported that systems express chirality components at level mechanism...
Peptide nanotubes are promising bio-inspired self-assemblies with a wide range of envisioned applications. The present review addresses the recent advances in their fundamental comprehension and mechanistic aspects latest downstream uses. Through well-documented examples, including Lanreotide peptide monodisperse nanotubes, molecular organisations interactions underlying such well-defined hierarchical nanoarchitectures particular examined. kinetic thermodynamic corresponding self-assembly...
While many numerical and experimental works were focused on water-ethanol mixtures at low ethanol concentration, this work reports predictions of a few physical properties (thermodynamical, interfacial, dynamical, dielectrical properties) mixture high alcohol concentrations by means molecular dynamics simulations. By using standard force field good agreement was found between experiment simulation. This allowed us to explore the dynamics, structure, interplay both hydrogen-bonding networks...
In many liposome applications, the nanomechanical properties of membrane envelope are essential to ensure, e.g., physical stability, protection, or penetration into tissues. Of all factors, lipid composition and its phase behavior susceptible tune mechanical membranes. To investigate this, small unilamellar vesicles (SUV; diameter < 200 nm), referred as liposomes, were produced using either unsaturated 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) saturated...
The thermotropic phase behavior of zwitterionic/cationic binary lipid mixtures is investigated and compared to its corresponding lipidic diagram complexed with DNA. We focus on isoelectric cationic lipid−DNA condensates where the number lipids equals phosphate groups Using differential scanning calorimetry, X-ray scattering, freeze fracture electron microscopy, film balance, we studied di-myristoyl-phosphatidyl-choline (DMPC) lipid, di-myristoyl-tri-methyl-ammonium-propane (DMTAP). shows...
Shining red–NIR light: Bright photoluminescent liquid crystals were obtained by grafting six promesogenic units onto an octahedral molybdenum cluster core (see picture). This hybrid self-arranges in a lamellar structure over wide range of temperatures to give the first clustomesogen. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The...
A detailed molecular organization of racemic 16-2-16 tartrate self-assembled multi-bilayer ribbons in the hydrated state is proposed where amphiphiles, ions, and water molecules are all accurately positioned by comparing experimental X-ray powder diffraction patterns derived from modeling studies. diffuse scattering studies show that not fundamentally altered when flat racemate to chirally twisted or helical pure enantiomer. Essential features three-dimensional organizations these structures...
We describe a method of controlled evaporation on textured substrate for self-assembling and shaping gold-nanorod-based materials. Tridimensional wall features are formed over areas as large several square millimeters. Furthermore, analyses by small-angle X-ray scattering scanning electron microscopy techniques demonstrate that colloids locally ordered smectic B phase. Such crystallization is in fact possible because we could finely adjust the nanoparticle charge, knowledge additionally...
Supramolecular self-assembly is an attractive pathway for bottom-up synthesis of novel nanomaterials. In particular, this approach allows the spontaneous formation structures well-defined shapes and monodisperse characteristic sizes. Because nanotechnology mainly relies on size-dependent physical phenomena, control monodispersity required, but possibility tuning size also essential. For self-assembling systems, shape, size, are settled by chemical structure building block. Attempts to change...
Significance The spectacular developments in cryoelectron microscopy involving new cameras, microscopes, and software make it possible today to routinely determine the atomic structures of a large range molecular assemblies. This has allowed us solve structure nanotubes formed from peptide, Lanreotide. Its gel, Somatuline, is used as synthetic growth hormone inhibitor treatment both acromegaly cancers. self-assembled nanotube results slow release form important pharmacologically. shows an...
The incorporation of lipophilic ligands into the bilayer membrane vesicles offers possibility to induce, upon binding suitable metal ions, a variety processes, in particular vesicle aggregation and fusion generation arrays, under control specific metal–ligand recognition events. Synthetic bipyridine lipoligands Bn bearing unit as head group were prepared incorporated large unilamellar vesicles. addition Ni 2+ or Co ions led formation complexes MBn 2 followed by spontaneous generate giant...
Poloxamers F88 (EO97PO39EO97) and P85 (EO27PO39EO27) are triblock copolymers of ethylene oxide (EO) propylene (PO), which have the same hydrophobic PO block. We studied aqueous solutions these two by conjoint use differential scanning calorimetry (DSC), rheology, small-angle X-ray scattering (SAXS). The results showed that temperature-induced micellization was a progressive process followed gelation for sufficiently concentrated samples. Gelation due to ordered packing micelles under...
Nanofabrication by molecular self-assembly involves the design of molecules and strategies so that shape chemical complementarities drive units to organize spontaneously into desired structures. The power makes it ubiquitous strategy living organized matter provides a powerful tool chemists. However, challenging issue in complex supramolecular structures is understand how kinetically efficient pathways emerge from multitude possible transition states routes. Unfortunately, very few systems...
Octahedral anionic rhenium clusters are obtained by high-temperature solid-state chemistry synthesis as single crystals or powders within which their charge is counter balanced alkali cations. The ceramic-like behavior of the Re6 based inorganic compound limits strongly use in functional devices. We present herein a facile route to introduce these self-organized hybrid organic–inorganic material. By replacing countercations mesogenic organic ones, polarized optical microscopy (POM), DSC,...
We report small-angle x-ray scattering (SAXS) experiments on aqueous dispersions of colloidal silica with a broad monomodal size distribution (polydispersity 18%, 8 nm). Over range volume fractions the particles segregate to build first one, then two distinct sets crystals. These thus demonstrate fractional crystallization and multiple-phase (bcc, Laves AB$_2$, liquid) coexistence. Their remarkable ability complex crystal structures from polydisperse population originates intermediate-range...
We report on a synchrotron x-ray diffraction study of saturated cationic lipid complexed with DNA. In the gel phase ${L}_{{\ensuremath{\beta}}^{\ensuremath{'}}}^{c}$ complexes exhibit Bragg reflections due to lamellar bilayer stacking and three nonintegral peaks in agreement an intercalated centered rectangular columnar superlattice The diffuse broadening DNA is caused by in-plane translational disorder strands approximated Lorentzians positional correlation lengths...
External stimuli are powerful tools that naturally control protein assemblies and functions. For example, during viral entry exit changes in pH known to trigger large conformational changes. However, the molecular features stabilizing higher structures remain unclear. Here we elucidate change of a self-assembling peptide forms either small or nanotubes dependent on pH. The sub-angstrom high-pH structure reveals globular conformation stabilized through strong histidine-serine H-bond tight...
Osteosarcoma is medically defined as a bone-forming tumor with associated bone-degrading activity. There lack of knowledge about the network that generates overproduction bone. We studied early stage osteosarcoma development mice enduring periosteum injection cells at proximal third tibia. On day 7 (D7), activate over-synthesis bone-like material inside medulla. This bone quickly (D13) followed by degradation. Samples were characterized microfocus small-angle X-ray scattering (SAXS),...