A5012671565- Immune Cell Function and Interaction
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Genetic factors in colorectal cancer
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Tryptophan and brain disorders
- Galectins and Cancer Biology
- Contact Dermatitis and Allergies
- Microscopic Colitis
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Escherichia coli research studies
Inserm
2016-2022
Institut des Maladies Génétiques Imagine
2017-2022
Université Paris Cité
2019-2022
Délégation Paris 5
2019
Descartes (Belgium)
2019
Institut Pasteur
2012-2018
Charité - Universitätsmedizin Berlin
2008-2015
German Rheumatism Research Centre
2015
Helmholtz Centre for Infection Research
2010-2013
Centre National de la Recherche Scientifique
2012
Gut microbes affect immunotherapy The unleashing of antitumor T cell responses has ushered in a new era cancer treatment. Although these therapies can cause dramatic tumor regressions some patients, many patients inexplicably see no benefit. Mice have been used two studies to investigate what might be happening. Specific members the gut microbiota influence efficacy this type (see Perspective by Snyder et al. ). Vétizou found that optimal anticytotoxic lymphocyte antigen blockade required...
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some which regulate types immune that are present in gut. For instance, Clostridium species bacteria induce a type cell promotes tolerance between host and its contents. Ohnmacht et al. Sefik characterized population gut regulatory mice, required microbiota to survive. Multiple bacterial could transcription factor–expressing helped maintain homeostasis. Mice engineered lack these factors exhibited...
The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), cell subset critically involved in maintenance self-tolerance prevention over-shooting immune responses. However, transcriptional regulation Foxp3 expression remains incompletely understood. We have previously shown that epigenetic modifications CpG-rich Treg-specific demethylated region (TSDR) locus are associated with stable expression. now...
Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of coeliac disease (CeD), often preceded by low-grade clonal intraepithelial lymphoproliferation, referred to as type II refractory CeD (RCDII). Knowledge on underlying oncogenic mechanisms remains scarce. Here, we analysed and compared the mutational landscape RCDII EATL in order identify genetic drivers CeD-associated lymphomagenesis.Pure populations RCDII-cells derived from intestinal biopsies (n=9) or sorted...
De novo induction of Foxp3⁺ regulatory T cells (Tregs) is particularly efficient in gut-draining mesenteric and celiac lymph nodes (mLN celLN). Here we used LN transplantations to dissect the contribution stromal environmental factors high Treg-inducing capacity these LN. After transplantation into popliteal fossa, mLN celLN retained their capacity, whereas skin-draining gut mesenteries did not enable Treg induction. However, de was abolished absence dendritic (DC), indicating that this...
Objectives Primary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from innate-like lymphocytes, may carry NK receptors (NKRs). Design NKRs expression was compared by flow cytometry in intraepithelial lymphocytes (IEL) CD, type I or II refractory CD (RCD). NKp46 next assessed immunohistochemistry paraffin-embedded...
Abstract Naturally occurring Foxp3+CD25+CD4+ regulatory T cells (Treg) have initially been described as anergic cells; however, more recent in vivo studies suggest that Tregs vigorously proliferate under both homeostatic well inflammatory conditions. We previously identified a subset of murine CD4+ Tregs, which is characterized by expression the integrin αEβ7 and displays an effector/memory-like phenotype indicative Ag-specific expansion differentiation. In present study, αE+ Treg was found...
Celiac disease (CeD), defined as gluten-induced enteropathy, is a frequent and largely underdiagnosed disease. Diagnosis relies on the detection of highly specific serum IgA anti-transglutaminase auto-antibodies demonstration duodenal villous atrophy. Treatment necessitates strict gluten-free diet, which resolves symptoms enables histological recovery. However, regular follow-up necessary to assess mucosal healing, emerges an important prognostic factor. Recent work CeD pathogenesis has...
Compelling evidence demonstrates that intestinal commensal microbiota modulate conventional and regulatory T cell (Treg) responses are required for effective host defence against pathogens avoidance of autoimmunity other immunopathologic conditions. Here, we investigated the contribution Toll-like receptor (TLR) signaling to homeostasis Foxp3(-) CD4(+) cells Foxp3(+) Tregs. Upon long-term antibiotics treatment, observed a significant reduction proliferation in systemic manner, whereas Treg...
Abstract Immune dysregulation and cytokine release syndrome have emerged as pathological hallmarks of severe Coronavirus Disease 2019 (COVID-19), leading to the evaluation antagonists therapeutic agents. A number immune-directed therapies being considered for COVID-19 patients are already in clinical use chronic inflammatory conditions like bowel disease (IBD). These considerations led us systematically examine intersections between GI tract during health intestinal inflammation. We observed...
Autoimmune enteropathy (AIE) is a severe form of characterized by chronic diarrhea refractory to any exclusion diet and associated with autoimmunity.1Schiepatti A. et al.Gut. 2022 Jun 8; (gutjnl-2021-326645)PubMed Google Scholar,2Villanacci V. al.Clin Immunol. 2019; 207: 10-17Crossref PubMed Scopus (14) Scholar Despite this clear definition, diagnosis challenging. The presence antienterocyte antibodies against the AIE-75kDa antigen3Kobayashi I. al.Gastroenterology. 1999; 117: 823-830Abstract...
ABSTRACT Objective Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of celiac disease (CeD), often preceded by low-grade clonal intraepithelial lymphoproliferation, referred to as type II refractory CeD (RCDII). Knowledge on underlying oncogenic mechanisms remains scarce. Here, we analysed and compared the mutational landscape RCDII EATL in order identify genetic drivers CeD-associated lymphomagenesis. Design Pure populations RCDII-cells derived from intestinal...