A5062801898- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Cervical Cancer and HPV Research
- Inflammatory Bowel Disease
- Pelvic and Acetabular Injuries
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Surgical Treatments
- Autoimmune and Inflammatory Disorders
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health, Medicine and Society
- Congenital gastrointestinal and neural anomalies
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Genital Health and Disease
- Herpesvirus Infections and Treatments
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Hidradenitis Suppurativa and Treatments
- Global Cancer Incidence and Screening
- Head and Neck Cancer Studies
- Ureteral procedures and complications
Hôpital Bichat-Claude-Bernard
2015-2024
Assistance Publique – Hôpitaux de Paris
2013-2024
Université Claude Bernard Lyon 1
2014-2024
Générale de Santé
2018-2023
Université Paris Cité
2010-2022
Hôpital Privé Jacques Cartier
2022
Centre Hospitalier Universitaire d'Angers
2021
Inserm
2004-2017
Foundation for Human Potential
2017
Groupe Hospitalier Intercommunal Le Raincy Montfermeil
2017
Objective: To describe the cases of anal cancer that appeared in French Hospital Database on HIV between 1992 and 2004 to study risk factors cancer. Methods: We examined incidence rates associated among 86 322 HIV-infected patients included HIV. Results: identified 132 cancer, including 124 men (94%), whom 75% had sex with men. Median age at diagnosis was 42.8 years (interquartile range: 36.9–49.4). At diagnosis, 103 (78%) were receiving combination antiretroviral therapy for a median 37.1...
PURPOSE: Anal incontinence affects approximately 10 percent of adult females. Damage to the anal sphincters has been considered as cause after childbirth in sole prospective study so far available. The aims present were determine prospectively incidence and sphincter damage their relationship with obstetric parameters. METHODS: We studied 259 consecutive females six weeks before eight delivery. They asked fill a questionnaire assessing fecal incontinence. endosonography (7-10 MHz) was then...
Abstract Anal cancer is a rare but its incidence increasing. Human papillomavirus (HPV) infection seems to be associated with the occurrence of most cases. The genotype‐specific prevalence HPV in anal was estimated assess potential benefit vaccination France. histological specimens were retrospectively recruited 2008 from 16 French centres and centrally tested for genotyping using INNO‐LiPA assay allowing detection 28 genotypes. Results analyzed according age, gender, HIV status when...
To study recent trends in the incidence of anal cancer HIV-infected patients receiving long-term combined antiretroviral treatment (cART) compared with general population.From French Hospital Database on HIV, we identified 263 cases invasive squamous cell carcinoma confirmed histologically between 1992 and 2008. We rates across four calendar periods: 1992-1996 (pre-cART period), 1997-2000 (early cART 2001-2004 2005-2008 (recent periods). Standardized ratios (SIRs) were calculated by using...
To assess the prevalence of and factors associated with squamous intraepithelial lesions condyloma [human papillomavirus (HPV)-related lesions) in HIV-infected patients.A cross-sectional study a tertiary-care university hospital conducted 516 consecutive outpatients.A systematic examination for macroscopic HPV-related through anoscopy histological confirmation, evaluation dysplasia HPV typing. Sexual behaviours were assessed using semi-directive questionnaire.Of 473 patients examined, (200...
Anal fistula plug [AFP] is a bioabsorbable bioprosthesis used in ano-perineal treatment. We aimed to assess efficacy and safety of AFP fistulising Crohn's disease [FAP-CD]. In multicentre, open-label, randomised controlled trial we compared seton removal alone [control group] with insertion [AFP 106 patients non- or mildly active having at least one tract drained for more than 1 month. Patients abscess [collection ≥ 3mm on magnetic resonance imaging recto-vaginal fistulas were excluded....
PURPOSE: Thrombosed external hemorrhoids and anal fissures are common responsible for severe discomfort during childbirth. However, the real incidence of these lesions is unknown. The aim our study was to evaluate their risk factors METHODS: A prospective with proctologic examination last 3 months pregnancy after delivery (within 2 months) performed in 165 consecutive pregnant females. RESULTS: Fifteen females (9.1 percent) (13 thrombosed fissures) were observed pregnancy. Fifty-eight (35.2...
Summary Association of drug‐induced hypersensitivity syndrome with viral infection is debated. Human herpesvirus 6 (HHV‐6) reactivation has been the most frequently reported associated this syndrome. However, a case cytomegalovirus (CMV) was recently described anticonvulsant‐induced We report severe allopurinol‐induced pancreatitis Epstein–Barr virus (EBV) infection. Active EBV demonstrated in two consecutive serum samples by presence anti‐EBV early antigen (EA) IgM antibodies and an...
To describe the prevalence of opioid-induced constipation (OIC) in patients with cancer pain according to Knowles-Eccersley-Scott symptom score (KESS), different symptoms bowel dysfunction (OIBD), and assess impact OIBD on patient's quality-of-life.A cross-sectional observational study, using KESS questionnaire physician's subjective assessment constipation, other questionnaires questions OIBD, quality-of-life, carried out 1 day at oncology centres hospitals.Five hundred twenty were enrolled...
Abstract Aim The study aimed to evaluate outcome at 1 year of one‐ and two‐stage fistulotomy for anal fistula in a large group patients. Method A prospective multicentre observational was designed include patients with treated by or fistulotomy. Data were collected using self‐administered questionnaire before surgery, during healing after surgery. Results Group (133 patients) low underwent one‐stage median Wexner scores surgery 1.0 (0−11) 2.0 (0−18) ( P = 0.032) the Vaizey (0−14) 3.0 (0−21)...
Introduction: Human papilloma virus (HPV) causes anal condyloma that is a risk factor for carcinoma. The incidence and mechanism of invasive carcinoma in patients with are prospectively determined. Patients methods: From 1993 to 2002, 228 consecutive (164 HIV positive) canal condylomas were included the study, after curing their lesions. They asked attend follow-up visits at 3- or 6-month intervals. We checked co-infection syphilis, gonococci, viruses (Epstein–Barr virus, cytomegalovirus,...
Internal sphincterotomy is the standard surgical treatment for chronic anal fissure, but frequently complicated by incontinence. Fissurectomy proposed as an alternative technique to avoid sphincter injury. We describe 1-year outcomes of fissurectomy.This was a prospective, multicentre, observational study. All patients with planned surgery fissure were included and had fissurectomy. Data collected before surgery, at healing, 1 year after Patient self-assessed symptoms quality life (using...
Current questionnaires designed to evaluate the burden of haemorrhoidal disease ignore symptoms such as bleeding, pain and itching. A specific questionnaire is needed global impact anal disorders on patients' daily lives.We developed a (HEMO-FISS-QoL) assess symptom administered it 256 patients (mean age 46.2 years; men 60.4%) with (67.2%), fissure (29.3%) or both (3.5%). Psychometric properties were evaluated by testing acceptability, construct validity reliability questionnaire. Principal...
Previous studies suggest a poor prognosis of epidermoid anal cancer in HIV+ patients.To investigate the long-term outcome and HIV- patients highly active antiretroviral treatment (HAART) era.We included all with referred to six hospitals from 1998 2004.In all, 151 (44 HIV+, 107 HIV-) were reviewed retrospectively for 27 (median 16-44) months. male (100% vs. 27%, P < 0.001) younger (45 62 years old, than patients. No significant differences observed tumour stage, pelvic radiotherapy dose or...
Anal disorders are largely underestimated in general practice. Studies have shown patients conceal anal symptoms leading to late diagnosis and treatment. Management by practitioners is poorly described. The aim of this study assess the prevalence their management In prospective, observational, national set France, all adult consulting practitioner during 2 days consultation were included. symptoms, whether spontaneously revealed or not, systematically collected assessed. For symptomatic...
Patients do not often discuss anal symptoms, resulting in late diagnosis of proctological disorders and impacting health. Poor epidemiological knowledge is a contributing factor to this, which can be significant problem general medicine. Authors evaluated the role family doctors by assessing how many these are spontaneously diagnosed after questioning patient.Thirty-nine practitioners completed targeted questionnaire assess all patients seen prospectively over 2.5 days consultations.A total...