A5061989092- Pelvic floor disorders treatments
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Anorectal Disease Treatments and Outcomes
- Dysphagia Assessment and Management
- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Gallbladder and Bile Duct Disorders
- Diverticular Disease and Complications
- Eosinophilic Esophagitis
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Congenital gastrointestinal and neural anomalies
- Helicobacter pylori-related gastroenterology studies
- Biliary and Gastrointestinal Fistulas
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Health, Medicine and Society
- Microbial Metabolism and Applications
- Systemic Sclerosis and Related Diseases
- Bariatric Surgery and Outcomes
- Probiotics and Fermented Foods
Hôpital Nord
2016-2025
Aix-Marseille Université
2016-2025
Assistance Publique Hôpitaux de Marseille
2016-2025
Centre Hospitalier Universitaire de Nice
2024
Hôpital Saint Joseph
2022
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2008-2019
Centre National de la Recherche Scientifique
2007-2019
Interface (United Kingdom)
2018
Inserm
2017
Méditerranée Infection Foundation
2017
Abstract Metagenomics revolutionized the understanding of relations among human microbiome, health and diseases, but generated a countless number sequences that have not been assigned to known microorganism 1 . The pure culture prokaryotes, neglected in recent decades, remains essential elucidating role these organisms 2 We recently introduced microbial culturomics, culturing approach uses multiple conditions matrix-assisted laser desorption/ionization–time flight 16S rRNA for identification...
This manuscript summarizes consensus reached by the International Anorectal Physiology Working Group (IAPWG) for performance, terminology used, and interpretation of anorectal function testing including manometry (focused on high-resolution manometry), rectal sensory test, balloon expulsion test. Based these measurements, a classification system disorders is proposed.Twenty-nine working group members (clinicians/academics in field gastroenterology, coloproctology, gastrointestinal...
Gastric peroral endoscopic pyloromyotomy (G-POEM) was introduced for treating refractory gastroparesis.To present a series of patients focussed on clinical mid-term efficacy and predictive outcomes factors.This single centre study 29 operated between January 2014 April 2016, with disturbed gastric emptying scintigraphy (GES) and/or elevated Gastroparesis Cardinal Symptoms Index (GCSI). The procedures were performed as previously described. primary endpoint the at 3 6 months, based GCSI...
The objective of this study was to show that although transcutaneous electrical tibial nerve stimulation (TENS) is being increasingly used treat fecal incontinence (FI), its efficacy has never been proved using controlled trials.In randomized, double-blind, sham-controlled trial, 144 patients aged 30-82 years from nine centers were randomly assigned receive either active or sham stimulations for 3 months. primary end point the response treatment based on number and urgency episodes....
Abstract Background Open studies have reported favourable results for sacral nerve stimulation in the treatment of refractory constipation. Here, its efficacy was assessed a double-blind crossover RCT. Methods Patients with at least two following criteria were included: fewer than three bowel movements per week; straining to evacuate on more 25 cent attempts; or sensation incomplete evacuation occasions. Response therapy defined as week and/or 50 improvement symptoms. Responders an initial...
Most studies on the human microbiota have analyzed stool samples, although a large proportion of absorption nutrients takes place in upper gut tract. We collected samples from different locations along entire gastrointestinal tract six patients who had simultaneously undergone endoscopy and colonoscopy, to perform comprehensive analysis using culturomics with matrix assisted laser desorption ionisation - time flight (MALDI-TOF) identification by metagenomics targeting 16S ribosomal...
Regular physical activity usually confers health benefits, but high-level sport may induce harmful outcomes, such as pelvic floor dysfunction. Urinary incontinence (UI) was previously documented, few data are available about anal (AI) in female athletes. Our aim to determine the role of practice on AI a young, healthy population.In this cross-sectional study, we included women aged 18-40 years. Self-administered questionnaires were delivered each volunteer. Two groups defined: (1) intensive...
Abstract Background 3D‐high definition anorectal manometry (3 DARM ) may aid the diagnosis of functional disorders, but data comparing asymptomatic and symptomatic subjects are scarce. We aimed to describe 3 values in volunteers those with fecal incontinence ( FI or chronic constipation CC ), identify which variables differentiate best these groups. Methods Asymptomatic were stratified by sex, age, parity. Those included according symptom questionnaires. Endoanal ultrasound examination...
Summary Background : Injecting fibrin glue has proved to be an effective means of treating anal fistulas (AF). There been some debate, however, as whether this technique should used on the AF often involved in Crohn's disease (CD). Aim To assess effectiveness injecting heterologous a refractory immunosuppressive treatment patients with CD. Methods Fourteen CD (five men and nine women, average age 42 years) presenting AFs were included study. Heterologous was injected into fistula tract under...
Sacral nerve stimulation is a technique commonly used for the treatment of idiopathic incontinence. This study was designed to assess efficiency sacral as means treating fecal incontinence in patients with Crohn's disease disrupted internal and external anal sphincters.Five (3 women) suffering from disease-related anoperineal lesions were treated by applying three weeks then permanent implantation. Endoanal ultrasonography showed that all these had sphincters.Continence improved patients....
Pelvic floor disorders are frequent, especially in women. Surgeons need more information on the accuracy of available diagnostic techniques to make therapeutic decisions.This study aimed compare dynamic anorectal endosonography and MRI defecography with conventional as criterion standard diagnosis pelvic disorders.We used a prospective crossover design which patients underwent each procedure random order within same month.Investigations were conducted at regional referral center Marseille,...
Recent developments in therapeutic endoscopic ultrasound (EUS) have enabled new approaches to the management of refractory gastrointestinal bleeding, including EUS-guided sclerotherapy and vessel embolization. Few cases been reported literature. Eight patients were admitted for severe, seven whom actively bleeding. Causes bleeding gastric varices secondary portal hypertension (n = 3); gastroduodenal artery aneurysm or fundal aneurysmal arterial malformation Dieulafoy's ulcer 2); latter five...