A5022683509- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Anorectal Disease Treatments and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Nerve Disorders
- Multiple Sclerosis Research Studies
- Urological Disorders and Treatments
- Health, Medicine and Society
- Gastrointestinal motility and disorders
- Sexual function and dysfunction studies
- Cardiovascular Syncope and Autonomic Disorders
- Myofascial pain diagnosis and treatment
- Systemic Sclerosis and Related Diseases
- Congenital gastrointestinal and neural anomalies
- Heart Rate Variability and Autonomic Control
- Spinal Dysraphism and Malformations
- Pregnancy-related medical research
- Pain Mechanisms and Treatments
- Dermatology and Skin Diseases
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Hernia repair and management
- Bladder and Urothelial Cancer Treatments
- Health Systems, Economic Evaluations, Quality of Life
Groupe de Recherche Clinique en Neuro-urologie
2016-2025
Hôpital Tenon
2016-2025
Sorbonne Université
2016-2025
Groupe de Recherche en Énergie Électrique de Nancy
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Hôpital Raymond-Poincaré
2021
Université de Perpignan
2020
Centre Hospitalier de Perpignan
2020
Hôpital Rothschild
2004-2019
King's College Hospital
2019
Abstract Aims The diagnosis of pudendal neuralgia by nerve entrapment syndrome is essentially clinical. There are no pathognomonic criteria, but various clinical features can be suggestive the diagnosis. We defined criteria that help to Materials and Methods A working party has validated a set simple diagnostic (Nantes criteria). Results five essentials are: (1) Pain in anatomical territory nerve. (2) Worsened sitting. (3) patient not woken at night pain. (4) No objective sensory loss on...
Of the various treatments proposed for urge incontinence, frequency and urgency electrostimulation has been widely tested. Different techniques have used with necessity of surgical implantation (S3 neuromodulation or sacral root stimulation) without requiring surgery (perineal transcutaneous electrostimulation). Recently peripheral electrical stimulation posterior tibial nerve was irritative symptoms in first intention intractable incontinence. Clinical studies demonstrated good results...
Abstract Aims Electrostimulation is an established therapeutic option for neurogenic urinary disorders. The aim of this study was to investigate the efficacy noninvasive technique transcutaneous posterior tibial nerve stimulation (TPTNS) in patients with multiple sclerosis (MS) and troublesome symptoms overactive bladder (OAB). Methods A multicentric enrolled 70 MS patients, suffering from OAB a 3‐month period. Intervention : Daily sessions 20 min TPTNS were provided. No change associated...
A prospective analysis of gait and strength parameters was performed in 100 patients diagnosed with MS pyramidal involvement admitted a rehabilitation unit. The were divided into two groups based on their ability to walk daily life (nonassisted or cane-assisted gait) four clinical subgroups depending associated involvements such as sensory loss cerebellar ataxia. Twenty healthy subjects studied control group. Gait evaluated Locometre muscle an isokinetic dynamometer. results showed that the...
<b>Objective:</b> The purpose of the study was to evaluate efficacy and safety botulinum A toxin in treatment detrusor sphincter dyssynergia multiple sclerosis patients. <b>Methods:</b> This a multicentre, placebo controlled, randomised, double blind study. Patients with chronic urinary retention were included if they had post-voiding residual urine volume between 100 500 ml. They received single transperineal injection either (100 U Allergan) or also 5 mg slow release alfuzosin bid over 4...
We evaluated the safety and efficacy of tension-free vaginal tape procedure for treating type II stress urinary incontinence in females.Between April 1998 1999, 62 women 28 to 86 years old (mean age 62.8) were treated consecutively with procedure. Preoperative evaluation included history, physical examination multichannel video urodynamics. All patients had incontinence, none preoperative detrusor instability or significant pelvic prolapse 16 previous surgery failed.All followed at least 12...
The objective of this study was to show that although transcutaneous electrical tibial nerve stimulation (TENS) is being increasingly used treat fecal incontinence (FI), its efficacy has never been proved using controlled trials.In randomized, double-blind, sham-controlled trial, 144 patients aged 30-82 years from nine centers were randomly assigned receive either active or sham stimulations for 3 months. primary end point the response treatment based on number and urgency episodes....
Abstract There are substantial advances in understanding disordered gastrointestinal autonomic dysfunction diabetes. It occurs frequently. The underlying pathogenesis is complex involving defects multiple interacting cell types of the myenteric plexus as well. These may be irreversible or reversible. Gastrointestinal symptoms represent a major and generally underestimated source morbidity for escalating health care costs Acute changes glycaemia both determinants consequences altered...
Abstract Aims To evaluate the potential of mirabegron, a selective β3‐adrenoceptor agonist, for treatment overactive bladder (OAB) symptoms. Methods A multicenter, randomized, double‐blind, double‐dummy, parallel group, placebo and active‐controlled, Phase 2, proof‐of‐concept study was conducted. Eligible patients (n = 314) were enrolled into single‐blind, 2‐week run‐in period followed by placebo‐controlled period. Patients received mirabegron 100 or 150 mg twice‐daily (BID), tolterodine 4...
The evaluation of chronic pelvic and perineal pain (CPP) is often complex. patient's description the appears to be disproportionate limited findings on physical examination and/or complementary investigations. concept central sensitization may allow better understanding management patients with CPP.The aim this study was elaborate a clinical tool designed simply identify in pain.A list 63 items submitted 22 international CPP experts according Delphi method.Ten criteria were adopted for...
Beyond its effect on vegetative functions, the activation of vagus nerve inhibits inflammation and reduces pain signaling. The aim this open-label pilot study was to determine efficacy tolerance transcutaneous auricular VNS (taVNS) erosive hand osteoarthritis (EHOA) symptoms. Symptomatic EHOA patients with VAS ≥ 40/100 mm ≥1 interphalangeal swollen joint(s) were included. taVNS performed for 4 weeks using an electrode applied one hour per day connected a TENS device pre-established settings....
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Oct 2003Tamsulosin: Efficacy and Safety in Patients With Neurogenic Lower Urinary Tract Dysfunction Due to Suprasacral Spinal Cord Injury PAUL ABRAMS, GERARD AMARENCO, AUGUST BAKKE, ANDRZEJ BUCZYŃSKI, DAVID CASTRO-DIAZ, SIMON HARRISON, GUUS KRAMER, ROBERT MARŠIK, PRAJSNER, MANFRED STÖHRER, PHILIP VAN KERREBROECK, JEAN JACQUES WYNDAELE, THE EUROPEAN TAMSULOSIN NEUROGENIC LOWER URINARY TRACT DYSFUNCTION STUDY GROUP ABRAMSPAUL...
Tolterodine is a potent antimuscarinic agent specifically developed for the treatment of urinary urge incontinence and other symptoms related to overactive bladder. In order assess optimum dosage use in future clinical studies, double-blind, randomized, placebo-controlled, parallel-group, multicenter study was performed 90 patients with detrusor hyperreflexia urgency, frequency, and/or incontinence. Urodynamic variables, micturition diary subjective were measured before after 2 weeks' either...
No AccessJournal of UrologyAdult urology1 Dec 2007Autonomic Nervous System Activity During Bladder Filling Assessed by Heart Rate Variability Analysis in Women With Idiopathic Overactive Syndrome or Stress Urinary Incontinenceis accompanied byIncreased α1-Adrenergic the Rat Depletion Ovarian Hormones Katelyne Hubeaux, Xavier Deffieux, Samer Sheikh Ismael, Patrick Raibaut, and Gérard Amarenco HubeauxKatelyne Hubeaux Université Pierre et Marie Curie-Paris 6, Faculté de Médecine, Unité Mixte...
To investigate the effect on urodynamics of 4 weeks treatment with solifenacin succinate in patients neurogenic detrusor overactivity (NDO) due to multiple sclerosis (MS) or spinal cord injury (SCI).SONIC was a prospective, multicenter, double-blind, phase 3b/4 study investigating efficacy and safety 10 mg NDO MS SCI. Patients (n = 189) were randomized placebo active (solifenacin 5 mg, oxybutynin hydrochloride 15 mg) for weeks, after 2-week, single-blind, run-in period. The primary endpoint...
Objective: Our aim was to assess the usefulness of cranberry extract in multiple sclerosis (MS) patients suffering from urinary disorders. Methods: In total, 171 adult MS outpatients with disorders presenting at eight centers were randomized (stratification according center and use clean intermittent self-catheterization) versus placebo a 1-year, prospective, double-blind study that analyzed using sequential method on an intent-to-treat basis. An independent monitoring board results analyses...