A5103026786- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Anorectal Disease Treatments and Outcomes
- Estrogen and related hormone effects
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Renal and related cancers
- Autophagy in Disease and Therapy
- Radiopharmaceutical Chemistry and Applications
- Pediatric Urology and Nephrology Studies
- Hemoglobinopathies and Related Disorders
- Hormonal and reproductive studies
- Heat shock proteins research
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Cancer Immunotherapy and Biomarkers
- Clusterin in disease pathology
- Diverticular Disease and Complications
National Center for Tumor Diseases
2020-2025
University Hospital Carl Gustav Carus
2019-2025
TU Dresden
2019-2025
Klinik und Poliklinik für Urologie
2015-2025
Deutschen Konsortium für Translationale Krebsforschung
2025
University Hospital Heidelberg
2020-2025
Helmholtz-Zentrum Dresden-Rossendorf
2020-2025
German Cancer Research Center
2020-2025
Heidelberg University
2020-2025
Charité - Universitätsmedizin Berlin
2003-2024
The hypochromic red cell is a direct indicator of functional iron deficiency (ID) in contrast to the majority biochemical markers, which measure ID indirectly via iron-deficient erythropoiesis. aim this study was evaluate extent these markers can distinguish from anemia chronic disease (ACD) as well combined state ID/ACD, using hemoglobinization gold standard.We studied 442 patients with various disease-specific anemias and 154 nonanemic patients. As indicators hemoglobinization, we measured...
No AccessJournal of UrologyAdult Urology1 Sep 2009Diagnosis and Surgical Management Colovesical Fistulas Due to Sigmoid Diverticulitis Sebastian Melchior, Dragan Cudovic, Jon Jones, Christian Thomas, Rolf Gillitzer, Joachim Thüroff MelchiorSebastian Melchior Department Urology, Johannes Gutenberg University Medical School, Mainz, Germany Urology/Transplantation Centre, Klinikum Bremen-Mitte, Bremen, Nothing disclose. More articles by this author , CudovicDragan Cudovic JonesJon Jones...
No AccessJournal of UrologyAdult Urology1 Feb 2010Incidence, Clinical Symptoms and Management Rectourethral Fistulas After Radical Prostatectomy Christian Thomas, Jon Jones, Wolfgang Jäger, Hampel, Joachim W. Thüroff, Rolf Gillitzer ThomasChristian Thomas Nothing to disclose. More articles by this author , JonesJon Jones JägerWolfgang Jäger HampelChristian Hampel ThüroffJoachim Thüroff Financial interest and/or other relationship with Pfizer. GillitzerRolf View All Author...
The progression to castration-resistant prostate cancer (CRPC) correlates with gain-of-function of the androgen receptor (AR) and activation AKT. However, as single agents, AR or AKT inhibitors result in a reciprocal feedback loop. Therefore, we hypothesized that combination an inhibitor antiandrogen might more profound, long-lasting remission CRPC. Here, report AZD5363 potently inhibits proliferation induces apoptosis cell lines expressing has anticancer activity vivo androgen-sensitive...
Resistance to antiandrogen drugs, like MDV3100, occurs in patients with castration-resistant prostate cancer (CRPC). Thus, preventing or treating resistance is a major clinical challenge. We identified novel antiandrogen, Compound 30, and compared its efficacy MDV3100. found that 30 inhibits androgen receptor (AR) activity LNCaP cells, C4-2 as well MDV3100-resistant cell lines. Compared treatment induces greater reduction AR, prostate-specific antigen (PSA), AR transcriptional activity,...
The objective of this study was to show that although transcutaneous electrical tibial nerve stimulation (TENS) is being increasingly used treat fecal incontinence (FI), its efficacy has never been proved using controlled trials.In randomized, double-blind, sham-controlled trial, 144 patients aged 30-82 years from nine centers were randomly assigned receive either active or sham stimulations for 3 months. primary end point the response treatment based on number and urgency episodes....
Abstract Purpose: Prostate cancer development is often associated with deletion or silencing of tumor suppressor phosphatase and tensin homolog (PTEN), a negative regulator the phosphoinositide 3 kinase (PI3K)–Akt pathway, leading to resistance various therapies in both preclinical clinical setting. Therefore, PI3K–Akt pathway plays central role cellular processes promoting survival signaling that can contribute malignant phenotype, and, consequently, an attractive pharmacologic target....
Abstract Small-molecule inhibitors of Hsp90 show promise in the treatment castrate-resistant prostate cancer (CRPC); however, these trigger a heat shock response that attenuates drug effectiveness. Attenuation is associated with increased expression Hsp90, Hsp70, Hsp27, and clusterin (CLU) mediate tumor cell survival resistance. We hypothesized preventing CLU induction this would enhance inhibitor–induced CRPC death vitro vivo. To test hypothesis, we treated inhibitor PF-04929113 or 17-AAG...
INTRODUCTION: Immune checkpoint inhibitors (ICI) have been approved for patients with clear cell renal carcinoma (ccRCC), but not all benefit from ICI. One reason is the tumor microenvironment (TME) that has substantial influence on patient's prognosis and therapy response. Thus, we comprehensively analyzed TME of ccRCC regarding prognostic predictive properties. METHODS: Tumor-infiltrating CD3-positive T-cells, CD8-positive cytotoxic T-lymphocytes (CTLs), regulatory B-cells, plasma cells,...
Abstract The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development progression prostate cancer (PCa). Therefore, protein linchpin current PCa therapies. Despite great research efforts, AR signaling pathway still not deciphered, emergence resistance biggest problem treatment. To discuss latest developments research, “1st International Androgen Receptor Symposium” offered forum for exchange clinical scientific...
Abstract The aims of this study were to diagnose iron-restricted erythropoiesis (functional iron deficiency) in patients with classic deficiency (ID), anemia chronic disease (ACD) and the combined state ID/ACD use two hematological methods for measurement reticulocyte hemoglobinization. In comparison, biochemical markers status determined. We studied 474 anemic admitted hospital a broad spectrum diseases. measured indicators CHr was determined on an Advia 120 hematology analyzer. A Sysmex...
This prospective study evaluated the efficacy and safety of local formalin application in chronic refractory radiation-induced hemorrhagic proctitis.All patients were treated under anesthesia by direct 4 percent to affected rectal areas.The included 33 (17 women) was conducted between January 1994 December 2001. There 11 anal cancers (33 percent), prostate cancers, 9 cervical or endometrial 1 bladder cancer, cancer. The mean number daily bleeds 2.7 (range, 0.5-15). Nineteen (58 percent)...
To investigate the associations between different overall or topographically restricted lymph node (LN) variables and cancer-specific survival (CSS) after radical cystectomy (RC) extended LN dissection (LND) with curative intent in patients LN-positive bladder cancer.Between 2001 2006, 152 had RC standardized LND for cancer intent. Patients positive LNs were stratified according to median of (LNs removed, number LNs, density). CSS was related variables, e.g. levels LND, relationships tested...
Local ablative radiotherapy (aRT) of oligometastatic prostate cancer (PCa) is very promising and has become a focus current clinical research. We hypothesize that aRT safe effective in gallium-68 prostate-specific membrane antigen targeted positron emission tomography (PSMA-PET)-staged PCa patients. A nonrandomized, prospective, investigator-initiated phase 2 trial recruited patients with (five or fewer lymph node osseous metastases) after local curative therapy, without significant...
22 Background: In preliminary analyses from the randomized phase 2, open-label CheckMate 650 trial, nivolumab (NIVO) 1 mg/kg (N1) plus ipilimumab (IPI) 3 (I3) Q3W × 4 doses showed clinical activity in patients (pts) with post-chemotherapy (post-CT) mCRPC, particularly those high tumor mutational burden (TMB), but early toxicity contributed to treatment discontinuations. Here, we report results pts post-CT mCRPC receiving alternative NIVO+IPI dosing regimens vs IPI alone cabazitaxel (CABA)...
Abstract Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind have not yet been deciphered, but mesenchymal phenotype associated with resistance. Mesenchymal phenotypes linked to metabolic rewiring, obtaining most ATP production by oxidative phosphorylation (OXPHOS) powered substantially glutamine (Gln). Likewise, Gln known play an essential role in modulating...
Robot-assisted and open radical prostatectomy (RARP ORP) are established procedures for localized prostate cancer, with comparable oncological functional outcomes. Little is known about patients' knowledge of both procedures. This study aimed to examine comparatively the informational behaviour patients undergoing ORP vs. RARP. prospective, multicentre included who underwent RARP or prior presurgery counselling. The questionnaires gathered information information-seeking behaviours their...
Patients with germ cell tumors have a good prognosis, which is partly due to platin-based chemotherapy. However, the long-term effects of CTx may play relevant role in effects. Up now, little known about knowledge that testicular tumor survivors these A survey patients treated at University Hospital Dresden from 2011 up 2021 was conducted. who had received were asked their therapy and Of 279 returns (6 deceased, 46 unavailable, 64% response), 198 CTx. This followed by 63 different...
Introduction and objective Robotic-assisted surgery (RAS) is widely adopted across surgical fields, notably urology, but patient knowledge remains limited, often shaped by misconceptions. Previous research indicates factors like age, profession, technology use influence RAS perceptions. This study investigates public knowledge, preferences, misconceptions about within a German cohort. Methods A cross-sectional survey at university hospital’s open house gathered responses from 339...
523 Background: Tyrosine kinase (TKI) and immune checkpoint inhibitors (CPI) are first-line options in metastatic renal cell carcinoma (mRCC). Most patients (pts) experience adverse events (AE) 20-30% discontinue therapies due to AEs. We tested whether proactive onco-coaching (POC) improved quality of life (QoL) with medical treatment. Methods: Adult treatment-naïve mRCC pts who were candidates for sunitinib (SU), axitinib + avelumab (AA) or pembrolizumab (AP) eligible. Treatment...