A5014583171- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Statistical Methods in Clinical Trials
- Colorectal Cancer Screening and Detection
- MRI in cancer diagnosis
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Ureteral procedures and complications
- Tissue Engineering and Regenerative Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Intraocular Surgery and Lenses
- Cancer Genomics and Diagnostics
- Exercise and Physiological Responses
- Global Cancer Incidence and Screening
- Renal and Vascular Pathologies
- Genital Health and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer survivorship and care
- Complementary and Alternative Medicine Studies
Martini-Klinik
2021-2025
Universität Hamburg
2022-2025
University Medical Center Hamburg-Eppendorf
2021-2025
Université de Montréal
2024-2025
Eppendorf (Germany)
2025
Heidelberg University
2021
National Center for Tumor Diseases
2021
University Hospital Heidelberg
2021
Objective: To test whether the contemporary robot-assisted nephroureterectomy (RNU) is associated with more favorable in-hospital outcomes than historical RNU, relative to same endpoints in open NU (ONU).
Radical prostatectomy (RP) may be a treatment option for prostate cancer in patients with chronic kidney disease (CKD). However, the effect of CKD on adverse in-hospital outcomes after RP is not well known. Descriptive analyses, propensity score matching (PSM), and multivariable logistic Poisson regression models were used to address National Inpatient Sample between 2005 2019. severity was stratified as mild (stage I/II) versus moderate III) severe IV/V). Of 191 050 patients, 4349 (2.3%)...
In this prospective two-center feasibility study, we evaluate the diagnostic value of intraoperative ex vivo specimenPET/CT imaging radical prostatectomy (RP) and lymphadenectomy specimens. Ten patients with high-risk prostate cancer underwent clinical prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) preoperatively on day surgery. Six received 68Ga-PSMA-11 four 18F-PSMA-1007. Radioactivity resected specimen was measured again using a novel...
Introduction: Leukemia history affects some radical prostatectomy (RP) patients. Although its prevalence and effect as an adverse risk factor are well known in cardiac surgery, the number of RP patients with a leukemia history, their rate in-hospital outcomes, unknown. Methods: We identified (National Inpatient Sample 2000–2019), stratified according to presence or absence history. Descriptive analyses, propensity score matching (PSM, ratio 1:10), multivariable logistic regression models...
BackgroundIn a subset of patients with oligorecurrent prostate cancer (PCa), salvage surgery prostate-specific membrane antigen (PSMA) radioguided (PSMA-RGS) seems to be value.ObjectiveTo evaluate whether lower level postoperative (PSA; <0.1 ng/ml) is predictive therapy-free survival (TFS) following PSMA-RGS.Design, setting, and participantsThis cohort study evaluated biochemical recurrence after radical prostatectomy PCa on PSMA positron emission tomography treated PSMA-RGS in three...
Robot-assisted and open radical prostatectomy (RARP ORP) are established procedures for localized prostate cancer, with comparable oncological functional outcomes. Little is known about patients' knowledge of both procedures. This study aimed to examine comparatively the informational behaviour patients undergoing ORP vs. RARP. prospective, multicentre included who underwent RARP or prior presurgery counselling. The questionnaires gathered information information-seeking behaviours their...
Background/Objectives: Radical prostatectomy (RP) may be considered for recurrent prostate cancer (PCa) following primary curative-intended local therapy. The effect of different prior therapies on patient-reported outcome measures (PROMs) after RP is not well defined. Methods: Validated PROMs (SF-12, EPIC-26, Decision Regret Scale) were used to compare health-related quality life (HRQOL) and functional status changes salvage radiotherapy (RT-sRP) or focal therapy (FT-sRP), relative RP....
To explore the rationale of unilateral extended pelvic lymph node dissection (ePLND) during radical prostatectomy (RP) by external validation a nomogram for ePLND (unilat-NG) and comparison to Briganti 2019 nomogram. Patients with magnetic resonance imaging-fusion biopsy consecutive RP bilateral were identified within an institutional database. The primary endpoint was detection rate invasion (LNI) contralateral prostatic lobe adverse cancer characteristics. performance unilat-NG detect LNI...
Radical prostatectomy (RP) may be a treatment option for prostate cancer patients with cirrhosis and liver disease (CLD). However, the effect of CLD on adverse in-hospital outcomes after RP has not been well described. Descriptive analyses, propensity score matching (PSM), multivariable logistic Poisson regression models were used to address National Inpatient Sample between 2005 2019. severity was stratified as mild vs. moderate/severe. Of 191,050 patients, 1,559 (0.8%) had CLD. those,...
ABSTRACT Purpose To quantify improvements in adverse in‐hospital outcomes between historical and contemporary robot‐assisted radical cystectomy (RARC) versus open RC (ORC). Material Methods Within the National Inpatient Sample (2010–2019), RARC ORC ileal conduit diversion patients were identified. Multivariable logistic Poisson regression models fitted. Results Of patients, 1343 (39%) (2010–2014) 2087 (61%) (2015–2019). 5812 (54%) 5019 (46%) contemporary. Versus counterparts, exhibited...
Background/Objectives: Adverse in-hospital outcomes at radical prostatectomy have not been specifically addressed in young patients aged 40–49 years (quadragenarians). Additionally, no comparison between robot-assisted (RARP) vs. open (ORP) has reported this population. Methods: Descriptive analyses, propensity score matching (PSM), and multivariable logistic/Poisson regression models quadragenarians undergoing RARP or ORP within the National Inpatient Sample (2009–2019). Results: Of 5426...
Mutations in DNA damage repair genes, particular genes involved homology-directed repair, define a subgroup of men with prostate cancer more unfavorable prognosis but therapeutic vulnerability to PARP inhibition. In current practice, mutational testing patients is commonly done late i.e., when the tumor castration resistant. addition, most sequencing panels do not include TP53, one crucial suppressor human cancer. this proof-of-concept study, we sought extend clinical use these molecular...
Abstract Objective In contrast to other malignancies, histologic confirmation prior treatment in patients with a high suspicion of clinically significant prostate cancer (csPCA) is common. To analyze the impact extracapsular extension (ECE), cT-stage defined by digital rectal examination (DRE), and PSA-density (PSA-D) on detection csPCA at least one PI-RADS 5 lesion (hereinafter, “PI-RADS patients”). Materials methods who underwent MRI/Ultrasound fusion biopsy (Bx) between 2016 2020 were...
Purpose of review This highlights recent advancements in radioguided surgery (RGS) for prostate cancer. Our objective is to provide expert insights into the state research, as reflected selected articles, and offer perspectives on clinical implications future directions that emerge from this rapidly evolving domain. Recent findings Key include potential PSMA-RGS improve detection lymph node invasion primary cancer, guide successful removal metastatic lesions oligorecurrent patients with...
It is not known whether cancer-specific mortality (CSM) differences distinguish radical cystectomy (RC) from trimodal therapy (TMT) in octogenarians harbouring organ-confined (T2N0M0) urothelial cancer of the urinary bladder (UCUB).
Abstract Purpose To compare the oncological and surgical outcomes of patients with recurrent prostate cancer (PCa) who underwent either open or newly established robot-assisted salvage prostate-specific membrane antigen–radioguided surgery (PSMA-RGS). Materials methods Patients consecutively PSMA-RGS for PCa recurrence between January 2021 December 2022 were identified. The rate complete biochemical response, recurrence-free survival [BFS], therapy evaluated. Univariable multivariable...