A5036695050- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Global Health and Surgery
- Prostate Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Renal and related cancers
- Travel-related health issues
- Pancreatic and Hepatic Oncology Research
- Global Health Workforce Issues
University Hospital Heidelberg
2020-2024
Heidelberg University
2020-2024
Mutations in DNA damage repair genes, particular genes involved homology-directed repair, define a subgroup of men with prostate cancer more unfavorable prognosis but therapeutic vulnerability to PARP inhibition. In current practice, mutational testing patients is commonly done late i.e., when the tumor castration resistant. addition, most sequencing panels do not include TP53, one crucial suppressor human cancer. this proof-of-concept study, we sought extend clinical use these molecular...
Introduction: DNA damage repair gene deficiency defines a subgroup of prostate cancer patients with early metastatic progression and unfavorable disease outcome. Whether in genes directly promotes dissemination is not completely understood. Methods: The migratory behavior cells was analyzed after siRNA-mediated knockdown checkpoint proteins, including BRCA2, ATM, others, using transwell migration assays, scratch assays staining for F-actin to ascertain cell circularity. Cells deficient BRCA2...
Defects in DNA damage repair genes characterize a subset of men with prostate cancer and provide an attractive opportunity for precision oncology approaches. The prevalence such perturbations newly diagnosed, treatment-naïve patients high risk lethal disease outcome, however, has not been sufficiently explored. Prostate specimens from 67 diagnosed early onset, localized high-risk/locally advanced or metastatic were included this prospective pilot study. Tumor samples, including 30 biopsies,...
<b><i>Background/Objective:</i></b> Clear cell renal carcinoma (ccRCC) is characterized by a high degree of functional intratumoral heterogeneity (ITH). This highlighted the finding that tumor proliferation and intracellular signaling occur preferentially in periphery. The driving forces for such spatial organization are largely unknown. Herein, we investigate role microenvironment control ITH. <b><i>Methods:</i></b> Conditioned media (CM)...