A5045476512- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Titanium Alloys Microstructure and Properties
- Metallurgy and Material Forming
- Electron and X-Ray Spectroscopy Techniques
- Renal cell carcinoma treatment
- Advanced Electron Microscopy Techniques and Applications
- Advanced materials and composites
- Microstructure and mechanical properties
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- High Temperature Alloys and Creep
- Renal and related cancers
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Chalcogenide Semiconductor Thin Films
- Urological Disorders and Treatments
- Advanced Semiconductor Detectors and Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Diagnosis and Treatment
- Solid-state spectroscopy and crystallography
- Microstructure and Mechanical Properties of Steels
- Coronary Interventions and Diagnostics
- Aluminum Alloys Composites Properties
Yamaguchi University
2016-2025
National Hospital Organization Mito Medical Center
2024-2025
Musashino Red Cross Hospital
2021-2024
Hitachi (Japan)
2012-2024
Kagawa University
2013-2024
Hitachi High-Tech (Japan)
2014-2024
Yamaguchi Prefecture Central Hospital
2024
Tokyo Medical and Dental University
2023
Yokohama Municipal Minato Red Cross Hospital
2023
Yamaguchi University Hospital
2020-2021
Significance The formation of the nuclei protein crystals has been suggested to occur within protein-rich mesoscopic clusters. existence such clusters revealed for many proteins; however, their role in crystallization is still unclear. Our live images a solution using transmission electron microscopy reveal that are solid amorphous particles work as heterogeneous nucleation sites. event crystal starts via another noncrystalline particle, which appears only few seconds before nucleation, is,...
High-entropy alloys (HEAs) are a class of metallic materials composed solid solutions five or more elements in equi- near-equiatomic proportions. The fascinating properties HEAs have recently attracted considerable attention for water-splitting applications. Mechanical alloying (MA) is method preparing that results crystalline, homogeneous at room temperature. In this work, several CoCuFeNi-based were prepared through MA and evaluated as electrocatalysts the oxygen evolution reaction (OER),...
Resistance to antiandrogen drugs, like MDV3100, occurs in patients with castration-resistant prostate cancer (CRPC). Thus, preventing or treating resistance is a major clinical challenge. We identified novel antiandrogen, Compound 30, and compared its efficacy MDV3100. found that 30 inhibits androgen receptor (AR) activity LNCaP cells, C4-2 as well MDV3100-resistant cell lines. Compared treatment induces greater reduction AR, prostate-specific antigen (PSA), AR transcriptional activity,...
Objectives Despite just a 4‐year interval from the last version (2015) of Clinical Practice Guidelines for Bladder Cancer, several dramatic paradigm shifts have occurred in latest clinical practice regarding both diagnosis and treatment bladder cancer. Herein, we updated 2019 Cancer under instruction Japanese Urological Association. Methods We previously reported revision working position paper edition described methods detail. Results The major points change are presented explanations given...
Organometal halide perovskites have attracted widespread attention as the most favorable prospective material for photovoltaic technology because of their high photoinduced charge separation and carrier transport performance. However, microstructural aspects within organometal perovskite are still unknown, even though it belongs to a crystal system. Here direct observation microstructure thin film using transmission electron microscopy is reported. Unlike previous reports claiming each phase...
Introducing promoters on cobalt-based catalysts for Fischer–Tropsch synthesis (FTS) have been found efficient adjusting their performance in converting syngas into long-chain hydrocarbons. Details of the promotion mechanism established atomic precise identification upon active sites structure as well electronic status is seldomly reported yet. In present work, we report direct valence and coordination configuration ZrO2 promoter additive over FTS under a wide range Zr/Co molar ratios from...
Abstract Background Enfortumab vedotin (EV) is an antibody‐drug conjugate showing significant overall survival (OS) benefit versus chemotherapy for patients with previously treated locally advanced or metastatic urothelial carcinoma (la/mUC) in EV‐301. This subgroup analysis was conducted to further analyze the efficacy and safety a Japanese population. Methods In open‐label, phase 3 EV‐301 trial, la/mUC were randomized 1:1 EV 1.25 mg/kg on Days 1, 8, 15 28‐day cycles...
Abstract Resident quiescent microglia have been thought to respond rapidly various pathologic events in the brain by proliferating and producing many bioactive substances, including proinflammatory cytokines nitric oxide (NO). In this study, we investigated reaction of traumatic ischemic lesions caused stab wounds transient 90‐min occlusion middle cerebral artery a mature rat brain. Although Iba1 + resident underwent apoptotic degeneration lesion core within 24 hr after onset insult as...
This article provides a model that regards the evolution behavior of friction coefficient in cylindrical compression test as function true strain on basis experimental results, allowing effect deformation curve at extremely high level to be evaluated and corrected for first time. The compressive tests were carried out stroke rate 1.2 mm/s IHS38MSV hypoeutectoid steel with various lubricants temperatures ranging from 800 °C 1200 °C. results showed process was not constant variation could...
In this study, locally advanced bladder cancer was treated by radiation combined with cisplatin therapy and a retrospective analysis conducted to predict the clinical response chemoradiotherapy (CRT) based on immunohistochemistry of apoptosis-related proteins.Sixty-two patients (median age, 68 years; range, 45-89 years) transitional cell carcinoma (pT1G3-pT4M0) CRT dose: 40.5 Gy 230 mg cisplatin) were studied. Mucosal biopsy performed before after CRT. Paraffin-embedded tumor specimens...
Although neurons and glia inevitably undergo degeneration in the core of ischemic lesions, many cells, particularly immune infiltrate survive it. Such infiltrating cells may play certain roles regeneration repair damaged brain tissues. In this study, we characterized macrophage-like that accumulated a rat whose right middle cerebral artery was transiently occluded for 90 mins. Many expressed Iba1, marker macrophages/microglia, as well NG2 chondroitin sulfate proteoglycan (NG2), which has...
In a transient 90-min middle cerebral artery occlusion (MCAO) model of rats, large ischemic lesion is formed where macrophage-like cells massively accumulate, many which express macrophage marker, Iba1, and an oligodendrocyte progenitor cell NG2 chondroitin sulfate proteoglycan (NG2); therefore, the were termed BINCs (Brain Iba1 + /NG2 Cells). A bone marrow transplantation experiment using green-fluorescent protein-transgenic rats showed that derived from marrow. 5-Fluorouracil (5FU)...