A5083903452- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Diet, Metabolism, and Disease
- Inflammatory Bowel Disease
- Pancreatitis Pathology and Treatment
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Digestive system and related health
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
Musashino Red Cross Hospital
2019-2024
Tokyo Medical and Dental University
2014-2023
University Hospital of Zurich
2018-2021
University of Zurich
2018-2021
The University of Tokyo
2014-2017
Graduate School USA
2015
National Center for Global Health and Medicine
2012-2014
A multisociety consensus group proposed a new nomenclature for metabolic dysfunction-associated steatotic liver disease (MASLD). Although patients with nonalcoholic fatty (NAFLD) are expected to be reclassified as MASLD under the nomenclature, concordance between and NAFLD remains unclear. Moreover, waist circumference could adjusted by ethnicity diagnosing MASLD; however, there limited data on optimal in Japanese population.
Autophagy plays important roles in metabolism, differentiation, and survival T cells. TNFAIP3/A20 is a ubiquitin-editing enzyme that thought to be negative regulator of autophagy cell lines. However, the role TNFAIP3 remains unclear. To determine whether regulates CD4 cells, we first analyzed Tnfaip3-deficient naïve cells vitro. We demonstrated exhibited reduced MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) puncta formation, increased mitochondrial content, exaggerated...
Ubiquitination is a crucial post-translational modification; however, the functions of ubiquitin-coding genes remain unclear. UBA52 encodes fusion protein comprising ubiquitin at N-terminus and ribosomal L40 (RPL40) C-terminus. Here we showed that Uba52-deficient mice die during embryogenesis. UBA52-deficient cells exhibited normal levels total ubiquitin. However, displayed decreased synthesis cell-cycle arrest. The overexpression ameliorated arrest caused by deficiency. Surprisingly, RPL40...
Magnetic resonance elastography (MRE) has the highest diagnostic accuracy for liver fibrosis; however, association between MRE-associated stiffness and development of hepatic extrahepatic complications as well mortality remains unclear.In this study, we investigated longitudinal mortality.This retrospective study included 2373 consecutive patients with chronic disease. All received standard care was assessed every 1-6 months.Newly diagnosed hepatocellular carcinoma (HCC), decompensation,...
The association between liver fibrosis, fatty liver, and cardiovascular disease (CVD) risk is unknown. Hence, this study aimed to investigate the of fibrosis with CVD independent already known comorbidities.This a prospective registered University Hospital Medical Information Network clinical trial registry (UMIN000036175). Liver was assessed by serum markers including FIB-4, nonalcoholic score (NFS), Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP), whereas...
Lenvatinib is an approved first-line therapy for unresectable hepatocellular carcinoma (HCC), but the effect of dose modification on its efficacy unclear. We analyzed relationship between relative intensity during initial 4 weeks [4W-relative (RDI)] and lenvatinib in real-world setting. A total 48 consecutive patients with HCC who received more than were included. The 4W-RDI was calculated as cumulative divided by weight-based standard dose, we evaluated association overall survival (OS)...
Abstract Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress the unfolded protein response (UPR), evolutionary mechanism that enables cells to cope with stressful conditions. ER activates autophagy, both play roles gut homeostasis contribute pathogenesis inflammatory bowel disease (IBD). Using a human epithelial cell model, we...
Background: Sarcopenia is associated with overall survival in patients hepatocellular carcinoma (HCC). However, it not known whether muscle volume clinical outcomes during combination therapy immune checkpoint inhibitors. We investigated the relationship between changes and treatment treated atezolizumab plus bevacizumab. Methods: Thirty-two HCC who received bevacizumab as first-line October 2020 February 2022 were included. Skeletal mass index (SMI) was calculated from skeletal area at L3...
Abstract Background and Aim Immune checkpoint inhibitors pose the risk of immune‐related adverse events (irAEs). Recent data suggest that irAEs may be associated with a favorable prognosis. This study aimed to investigate analyze association between these clinical benefits in patients unresectable hepatocellular carcinoma. Methods The enrolled 130 advanced carcinoma treated atezolizumab plus bevacizumab November 2020 January 2023 at single center. relationship both response rate...
We aimed to explore the relative dose intensity (RDI) and post-regorafenib treatments in regorafenib therapy.The medical records of 38 patients treated with between July 2017 June 2019 at our institution were collected. The RDI for first month (1M-RDI) was calculated.The overall survival (OS) progression-free (PFS) 12.4 3.7 months. objective response rate disease control 13.2% 71.1%. median total 2080 mg (240-3360 mg), 1M-RDI 61.9% (7.1%-100%). Patients ≥ 50% showed significantly longer OS...
Local extracellular acidification is associated with several conditions, such as ischemia, cancer, metabolic disease, respiratory diseases, and inflammatory bowel disease (IBD). Several recent studies reported a link between IBD family of pH-sensing G protein-coupled receptors. Our previous point to an essential role for OGR1 (GPR68) in the modulation intestinal inflammation fibrosis. In current study, we evaluated effects novel inhibitor murine models colitis.The small-molecule were...
Abstract Background Patients with nonalcoholic fatty liver disease (NAFLD) are highly at risk for cardiovascular (CVD). However, the of developing CVD in patients lean NAFLD is not yet fully understood. Therefore, this study aimed to compare incidence Japanese and those non-lean NAFLD. Methods A total 581 (219 362 NAFLD) were recruited. All underwent annual health checkups least 3 years, was investigated during follow-up. The primary end-point years. Results 3-year new rates 2.3% 3.9%,...
Ubiquitin chains are formed with 8 structurally and functionally distinct polymers. However, the functions of each polyubiquitin remain poorly understood. We developed a polyubiquitin-mediated fluorescence complementation (PolyUb-FC) assay using Kusabira Green (KG) as split fluorescent protein. The PolyUb-FC has advantage that monoubiquitination is nonfluorescent chain-specific polyubiquitination can be directly visualized in living cells without antibodies. applied to examine K33-linked...
Aim Tyrosine kinase inhibitor (TKI) therapy resulted in better prognosis for patients with hepatocellular carcinoma (HCC). However, some cases Barcelona Clinic Liver Cancer (BCLC) stage C disease still had poor prognosis. This study aimed to investigate and characteristics of HCC treated TKI based on liver function the extent portal vein tumor thrombosis (PVTT). Methods Patients receiving ( n = 345) were recruited retrospectively. Child–Pugh score albumin–bilirubin (ALBI) used assessment...
Abstract Aim Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy. However, the characteristics and prognosis of ICC not well known. This study aims to reveal relationship between liver function ICC. Methods A total 83 patients were recruited retrospectively from March 2009 August 2020. Child–Pugh (CP) albumin–bilirubin (ALBI) scores used assess function. The extent portal vein tumor thrombosis (PVTT) was classified Vp0 Vp4. end‐point for this analysis overall survival...
The prediction of hepatocellular carcinoma (HCC) development during nucleotide/nucleoside analog (NA) therapy is clinically important in patients with chronic hepatitis B. Although several useful models for HCC have been previously reported, their usefulness the Japanese population unclear. Therefore, this study examines applicability these patients.Four hundred forty-three no history who were treated entecavir, tenofovir alafenamide, or disoproxil fumarate enrolled. PAGE-B, modified-PAGE-B,...
The serum hepatitis B core-related antigen (HBcrAg) is considered a surrogate marker of the amount and activity intrahepatic covalently closed circular DNA. This study aims to investigate virological characteristics HBcrAg in chronic (CHB) patients reveal hepatocellular carcinoma (HCC) risk factors e (HBeAg)-negative patients.Hepatitis was measured 245 naive CHB before receiving nucleoside/nucleotide analog (NA) therapy. All were NA (entecavir, tenofovir disoproxil fumarate, alafenamide)...
Conversion surgery (CS), which aims to cure after systematic therapy, is only scarcely reported in the field of hepatocellular carcinoma (HCC). However, advancements systemic therapy for HCC are expected increase candidates eligible CS because higher response rate. The aim this study was clarify characteristics patients who underwent tyrosine kinase inhibitor (TKI) therapy.
Aim Lenvatinib (LEN) is a newly approved, multikinase inhibitor for treating unresectable hepatocellular carcinoma. In the present study, we investigated impact of three different criteria evaluating radiological objective response (OR) on overall survival in real‐world data. Methods Consent LEN therapy was obtained from 51 patients April 2018 to March 2019. A total 40 who received minimal cumulative duration 4 weeks were included analysis. Enhanced computed tomography scan performed at...
Adherence to nucleotide/nucleoside analog therapy is important in improving prognosis chronic hepatitis B. We aimed compare medical adherence and satisfaction with entecavir (ETV) tenofovir alafenamide (TAF) assess the effect of switching from ETV TAF. Patients taking (n = 114) TAF 35), who switched 15) were included. Medication assessed using a questionnaire. There was no significant difference between groups, but medication rates (0-10, prefer-dislike) 1.72 ± 2.2 0.69 1.5, respectively (P...
We report a rare case of angiosarcoma involving the gastrointestinal tract, liver, spleen, pancreas, kidney, lung and vertebrae, as well bulky dissemination in pleuroperitoneal membranes. A 72-year-old man with no history illness became aware melena. Laboratory findings revealed anemia, upper endoscopy multiple reddish nodules stomach duodenum. However, biopsy specimens showed evidence histological features. Computed tomography fluorodeoxyglucose positron emission space-occupying lesions...
Background: Recent advances in the development of tyrosine kinase inhibitors (TKIs) have enabled patients with unresectable hepatocellular carcinoma (HCC) to receive multiple TKIs sequence. The aim this study was identify predictors good candidates for second-line treatment after disease progression during sorafenib treatment. Methods: This is a retrospective cohort 190 consecutive HCC who were treated our hospital. Three criteria TKI at time defined as follows: criterion 1 same inclusion...