A5016653415- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer Cells and Metastasis
- Digestive system and related health
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Diagnosis and treatment of tuberculosis
- Renal and related cancers
- Systemic Lupus Erythematosus Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- Pancreatitis Pathology and Treatment
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders
- COVID-19 and healthcare impacts
- Adrenal Hormones and Disorders
- Hidradenitis Suppurativa and Treatments
- Pregnancy and Medication Impact
- Galectins and Cancer Biology
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Ion Transport and Channel Regulation
Tokyo Medical and Dental University
2016-2024
Daiichi-Sankyo (South Korea)
2024
Unidad de Cirugía Artroscópica
2023
Matsuyama Red Cross Hospital
2022
The University of Tokyo
2020-2021
Intestinal stem cells (ISCs) play indispensable roles in the maintenance of homeostasis, and also regeneration damaged intestinal epithelia. However, whether inflammatory environment Crohn's disease (CD) affects properties resident small remain uncertain.CD patient-derived organoids were established from enteroscopic biopsy specimens taken active lesions (aCD-SIO), or mucosa under remission (rCD-SIO). Expression ISC-marker genes those was examined by immunohistochemistry, microfluid-based...
ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs). However, comprehensive contribution ATOH1+ IECs to homeostasis, repair, and tumorigenesis epithelium remains uncertain. Through our cell-lineage tracing, we show here that definite number retain stem cell properties can form ATOH1+IEC-derived clonal ribbons (ATOH1+ICRs) under completely homeostatic conditions. Interestingly, colonic appeared exhibit their function more...
Intestinal epithelial cells (IECs) play an indispensable role in maintaining body fluid balance partly through their ability to regulate anion/fluid secretion. Yet various inflammatory gastrointestinal diseases, over-secretion of anions results symptoms such as severe diarrhoea. Endogenous mediators, vasoactive intestinal peptide or prostaglandin E2 (PGE2), secretion, but direct effect on purified human IECs has never been described detail. Based a previously organoid swelling model, we...
INTRODUCTION: Leucine-rich alpha-2 glycoprotein (LRG) is a newly studied biomarker for inflammatory diseases. This study aimed to investigate whether LRG can be used evaluating transmural activity in patients with Crohn's disease (CD). METHODS: We performed magnetic resonance enterography (MRE) 227 consecutive CD from June 2020 August 2021. prospectively compared MRE findings clinical and laboratory data including LRG. was evaluated using 2 validated scoring systems, inflammation defined as...
Tofacitinib and upadacitinib are small-molecule compounds that inhibit the Janus kinase pathway for treatment of refractory ulcerative colitis. Only a few reports have compared efficacy safety these 2 drugs in real-world practice. We aimed to show our evidence compare profiles This study is single-center retrospective analysis. Patients treated with tofacitinib or at hospital between June 2018 January 2024 who were monitored 24 weeks included. The primary outcome was steroid-free clinical...
Several studies have reported a positive correlation between serum drug concentrations and endoscopic remission in patients with Crohn's disease.To examine the association of cytokine blockers (infliximab, adalimumab ustekinumab) small bowel lesions.This was cross-sectional study conducted at single tertiary referral centre. Patients disease who received maintenance blocker therapy were recruited from April 2018 to May 2020. We performed balloon-assisted enteroscopy collected samples measure...
Endoscopic activity confirmed by enteroscopy is associated with poor clinical outcome in Crohn's disease (CD). We investigated which of the existing biomarkers best reflects endoscopic CD patients including small bowel, and whether their combined use can improve accuracy.
The intestinal epithelium of inflammatory bowel disease [IBD] patients is exposed to various pro-inflammatory cytokines, most notably tumour necrosis factor alpha [TNF-α]. We have previously shown that the Notch signalling pathway also upregulated in such an epithelium, contributing epithelial cell [IEC] proliferation and regeneration. aimed reproduce environment vitro explore gene regulation involved. Human IEC lines or patient-derived organoids were used analyse Notch- TNF-α-dependent...
Abstract Background The importance and pathophysiology of transmural healing in patients with Crohn’s disease [CD] remains to be verified. We aimed examine the association between serum concentrations biologics remission evaluated via magnetic resonance enterography [MRE]. Methods enrolled CD who received maintenance 1 year after induction prospectively followed up for at least baseline laboratory, endoscopic MRE examination. relationship factors including presence patient prognosis, as well...
The efficacy and safety of tofacitinib for the treatment refractory ulcerative colitis (UC) has been demonstrated in clinical trials. Although, a series reports with real-world evidence its short-term profiles have already published, long-term data limited. We aimed to show our 3-year on use UC, focusing profiles.
Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α may synergistically promote expression stem cell (ISC) marker OLFM4 human IECs. In present study, we investigated gene regulation function IEC lines. We confirmed upregulate mRNA OLFM4. Luciferase reporter assay showed transcription regulated by synergy Notch. At protein level, between...
Summary Background Mucosal healing is an important treatment target in patients with ulcerative colitis. Aims To explore the optimal colonoscopic strategy to determine risk for clinical relapse Methods We enrolled 325 consecutive colitis and biochemical remission from April 2018 March 2019. Five colonic segments were endoscopically histologically assessed systematically. For endoscopic evaluation, we used three different modes of Ulcerative Colitis Endoscopic Index Severity (UCEIS):...
Summary Background Although 5‐aminosalicylate (5‐ASA) is the therapy of first choice in ulcerative colitis (UC), some patients cannot tolerate it because side effects. Previous reports have not investigated whether 5‐ASA intolerance associated with risk colectomy. Aim To investigate associations between tolerance and colectomy among UC Methods The data who visited any three hospitals during 2014‐2018 around Tokyo, Japan, were retrospectively obtained from medical records. Patients...
Abstract Background and study aims Although small hypervascular tumors are suspected to be pancreatic neuroendocrine (p-NENs), their diagnosis treatment challenging. This evaluated the usefulness of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for p-NENs. Methods All p-NEN lesions that underwent EUS-TA at our hospital between April 2018 December 2023 were retrospectively analyzed. The diagnostic sensitivity concordance rate grading with surgical specimens examined. grouped by...
Abstract Background Small intestinal stricture is a major cause for surgery in Crohn’s disease (CD). Endoscopic balloon dilation (EBD) performed small strictures to avoid surgery, often repeatedly. However, factors that are associated with prognosis after EBD of remain poorly investigated. Mucosal healing the therapeutic target CD. We aimed investigate impact mucosal defined by presence ulcers at site on CD patients. Methods retrospectively included patients who underwent initial...