A5076491310- Inflammatory Bowel Disease
- Microscopic Colitis
- Diverticular Disease and Complications
- Helicobacter pylori-related gastroenterology studies
- Pregnancy and Medication Impact
- Autoimmune and Inflammatory Disorders
- Reproductive System and Pregnancy
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Ocular Diseases and Behçet’s Syndrome
- Eosinophilic Esophagitis
- Pharmacological Effects of Natural Compounds
- Celiac Disease Research and Management
- Appendicitis Diagnosis and Management
- Pharmaceutical studies and practices
- Veterinary medicine and infectious diseases
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Immunodeficiency and Autoimmune Disorders
- Diet, Metabolism, and Disease
- Nosocomial Infections in ICU
- Parasitic Infections and Diagnostics
- Gastrointestinal disorders and treatments
Yokohama City University
2014-2025
Yokohama City University Medical Center
2019-2025
Hospital Universitario de La Princesa
2014
Nippon Medical School
1973
Summary Background Endoscopic healing (EH) is a therapeutic target in ulcerative colitis (UC). However, even patients who have achieved EH relapse frequently. Aims To investigate the association between recent steroid use and risk UC with EH. Methods This multi‐centre cohort study included 1212 confirmed (Mayo endoscopic subscore ≤1). We excluded current systemic or history of advanced therapy. divided into group (last within 1 year; n = 59) non‐recent steroid‐naïve ( 1153). followed for 2...
Background:Patients with inflammatory bowel disease (IBD) occasionally require central venous catheter (CVC) placement to support a therapeutic plan. Given that CVC can predispose patients infection, this investigation was undertaken assess the incidence, risk factors, and outcomes of CVC-related blood stream infection (CRBSI) in IBD during routine clinical practice.
To the Editors, Ulcerative colitis (UC) is a chronic inflammatory disease affecting colon. The pathogenesis multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors.1 We herein report patient with UC who developed in both colonic autotransplant neovagina residual colon simultaneously. Direct exposure to dietary antigens, fecal stream, or intestinal bacteria mucosa speculated trigger for UC, but our case provides...
Abstract Background In women with inflammatory bowel disease, at least 3 months of preconception corticosteroid-free remission (CFREM) is recommended by experts in current consensus statements. However, data are lacking on the appropriate period. We investigated CFREM period ulcerative colitis to reduce maternal disease activity and adverse pregnancy outcomes (ie, preterm birth, low birth weight, small for gestational age). Methods retrospectively examined 141 pregnancies 2 institutions....
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe case a 64-year-old woman who developed multiple synchronous early cancers without H. infection. Nine lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that tumors positive for mucin (MUC)2, MUC6, CDX2, but negative MUC5AC, suggesting...
Intestinal Behçet disease is typically associated with ileocecal punched-out ulcers and significant morbidity mortality. ultrasound a noninvasive imaging technique for monitoring. However, no previous reports have compared intestinal endoscopic ulcer activity or histopathological findings disease. We evaluated the usefulness of assessing in
The aim of this study is to clarify whether trans-abdominal ultrasound (TAUS) can reflect actual intestinal conditions in Crohn's disease (CD) as effectively water-immersion (WIUS) does. This retrospective enrolled 29 CD patients with 113 lesions. Five (US) parameters (distinct presence/indistinct presence/disappearance wall stratification the submucosal and mucosal layers; thickened layer; irregular surface; increased fat wrapping around bowel wall; fistula signs) that may indicate...
Clinical: Therapy & observation S271 potential for confounding variables from data obtained in the GEMINI 1 study (NCT00783718).Methods: Exploratory plots of week 6 clinical response (decrease complete Mayo score 3 points and 30% baseline, a decrease rectal bleeding subscore point or an absolute point) remission (complete 2 no >1 versus individual predicted average VDZ concentration (C ), derived population PK model, were generated using study.ERRs assessed logistic regression which adjusted...
Objectives: Transabdominal ultrasonography is a common and accurate tool for managing Crohn’s disease (CD); however, the significance of resulting data poorly understood. This study was performed to determine association between bowel wall thickness evaluated by water-immersion macroscopic severity, namely, refractory inflammation subsequent fibrosis in CD surgical specimens.Materials methods: We retrospectively 100 segments colon small intestine from 27 patients with CD. The resected...
The mean time of UC evolution until MSZ withdrawal was 7.1 ± 6.0y.MSZ treatment maintained during a median 48 months (mean dose 1.9 0.9g per day), and 34.3% patients were on topical that also withdrawn.Reasons for withdrawing long-term remission (n = 15; 42.9%, 84.0 47.5 months), patient's choice 18; 51.4%), side effects 2; 5.7%).Globally, 57.1% had at least one flare after period without (median to first 27 (IQR 8-78); 71.4% relapse the year follow-up); 40% required oral...
The mean time of UC evolution until MSZ withdrawal was 7.1 ± 6.0y.MSZ treatment maintained during a median 48 months (mean dose 1.9 0.9g per day), and 34.3% patients were on topical that also withdrawn.Reasons for withdrawing long-term remission (n = 15; 42.9%, 84.0 47.5 months), patient's choice 18; 51.4%), side effects 2; 5.7%).Globally, 57.1% had at least one flare after period without (median to first 27 (IQR 8-78); 71.4% relapse the year follow-up); 40% required oral...
Abstract Background Intestinal Behçet's disease (BD) is a relapsing-remitting typically associated with punched-out ulcers in the ileocecal region. Optimal monitoring of activity necessary; however, ileocolonoscopy cannot be performed on regular basis as it invasive, resource-intensive and causes considerable patient discomfort. Furthermore, there are risks intestinal bleeding perforation caused by pretreatment laxatives air insufflation during examination. Hence, other follow-up...
Abstract Background 5-aminosalicylic acid (5-ASA) is widely used as a first-line treatment for ulcerative colitis (UC), but intolerance sometimes occurs. 5-ASA-intolerance was considered risk factor colectomy in UC patients, no reports have examined which suitable to avoid 5-ASA-intolerant patients. This the first report describing strategy UC. The aims of this study were determine optimal therapeutic Methods retrospective cohort involved patients who newly diagnosed having after January...
Abstract Background Biologics are widely used for paediatric Crohn's disease (CD) and highly effective; however, primary inefficacy the emergence of secondary during long-term use remain challenges. Although it is desirable biologics in patients to be safe usable long-term, there few detailed reports on comparison persistence rates patients. Methods This was a multicentre prospective cohort study using web-based registry system Japan that performed between October 2012 March 2020. New...
Abstract Background Five-aminosalicylic acid (5-ASA) compounds are used as the primary treatment for ulcerative colitis (UC); however, some patients intolerant to this drug. There have been few studies on natural history and clinical outcomes of 5-ASA patients. The aim study was elucidate in terms colectomy, immunomodulator use, biologic (anti-tumour necrosis factor (TNF) Vedolizumab) therapy. Methods Data were obtained by a retrospective review charts 2065 consecutive with UC who treated at...
Abstract Background Serrated polyps are recognized as precursors of colorectal cancer in general population and have recently been reported patients with ulcerative colitis (UC). However, their prevalence detailed characteristics remain unclear. Methods The clinicopathological biological serrated UC were retrospectively examined a single tertiary inflammatory bowel disease centre Japan from 2000 to 2020. Results In total, 252 neoplasms, including 36 (26 colitis-affected segments, 10...
Abstract Background Current consensus statements recommend at least 3–6 months of preconception steroid-free remission for women with inflammatory bowel disease, as determined by experts. However, little data is available on the appropriate period in ulcerative colitis (UC). We explored effect disease activity during pregnancy and birth outcomes UC. Methods Data were obtained from a retrospective chart review 141 consecutive pregnant UC our centre related clinic 2000–2020. Women who...
We report a case that an ileo-ileal fistula in the pelvis due to Crohn's disease adhered rectum, formed abscess, and resulted multiple nodular protrusion rectum resembling phlegmonous colitis. In disease, inflammation of ileum may spread form cystic or rectal fistulas. It was considered rare endoscopic finding could be seen disease.
Pregnancy is a known risk factor for amebic enteritis, which develops into potentially fatal fulminant enteritis in some cases. We describe case of 27-year-old non-immunosuppressed pregnant woman with complicated cytomegalovirus enteritis. She improved intensive care and intravenous metronidazole ganciclovir but eventually required subtotal colectomy intestinal stenosis. It difficult to diagnose especially non-endemic area. Amebic must be considered as differential diagnosis refractory...